Case study: management of advanced prostate cancer with soft tissue metastases

Kirby, Roger

doi:10.1038/sj.pcan.4500814

Cited by 6 publications

(11 citation statements)

References 14 publications

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“…Generally, palliative treatment, such as radiation therapy, is chosen because of the dismal prognosis of patients with metastasis. In the present case, the prognosis was thought to be relatively better than the other cancer; in fact, the prognosis of prostate cancer with bone metastasis is reported as 3.0–3.5 years [1]. Furthermore, an amputation would bring about unacceptable degree of functional disability, because the affected hand was dominant.…”

Section: Case Presentationmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

“…After assessment of disease risk, patients should be informed about the benefits and side effects of all options [1]. In addition, the presence of bone metastases reduces median survival to about 3.0–3.5 years [1]. The patient in this study was informed of the risks of surgery and prognosis of the disease and chose wide resection in combination with reconstruction of the thumb by pollicization of the index finger, allowing the affected thumb to retain its function.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Prostate Cancer of Hand

Nagano

Ohno

Oshima

et al. 2016

Case Reports in Orthopedics

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Soft tissue metastases of prostate cancer to other sites are extremely rare, and, to our best knowledge, there have been no reports of metastasis to soft tissue of the hand. A 63-year-old man was diagnosed with prostatic cancer. During treatment, bone and soft tissue metastases to the right hand, appearing in the first web space, were observed. The tumor was resected, along with both the first and second metacarpal bones. The thumb was reconstructed by pollicization of the remaining index finger, enabling the patient to use the pollicized thumb for activities of daily living. This is the first case report of prostate cancer metastasizing to the soft tissue in hand. After wide resection, pollicization was able to reconstruct a functional hand and thumb.

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Section: Case Presentationmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metastatic Prostate Cancer of Hand

Nagano

Ohno

Oshima

et al. 2016

Case Reports in Orthopedics

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“…Furthermore, the metastatic pattern in the present patients was peculiar in terms of soft-tissue involvement, as 50% had lymph-node metastasis, 22% had pulmonary metastasis, while 11% had liver metastasis on presentation. Soft-tissue metastasis on its own constitutes a poor prognostic criterion [23] .…”

Section: Discussionmentioning

confidence: 99%

An early-detection programme for prostate cancer in Saudi men: A call from a tertiary-care centre in the Eastern province

Osman

Gomha

Harb

et al. 2014

Arab Journal of Urology

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ObjectiveTo review the mode of presentation and clinical course of patients with prostate cancer during a specified period, as the detection rate is tending to increase, with most patients presenting at an advanced stage, and yet the overall incidence and prevalence rates are low.Patients and methodsWe retrospectively reviewed all aspects of care for patients who were diagnosed between May 2006 and July 2010.ResultsIn all, 76 men had a histologically confirmed prostatic adenocarcinoma diagnosed between May 2006 and July 2010 (mean age 71.1 years, SD 8). The median (range) prostate-specific antigen level at diagnosis was 52 (1.2–16,230) ng/mL. Of the patients, 74% had a Gleason grade of ⩾ 7 on diagnosis, and 64% had extraprostatic disease on presentation. Active surveillance was adopted in four patients, and four others were maintained on watchful waiting. Six patients had a radical prostatectomy, in one of whom it was a salvage procedure. Six patients received external-beam radical radiotherapy, five of whom had neoadjuvant, concurrent and adjuvant hormonal therapy. All remaining patients were treated primarily with androgen-deprivation therapy (ADT). Of the patients on hormonal manipulation, in 56% the cancer became castrate-resistant within the mean (SD) follow-up of 17.2 (15) months. Of patients treated primarily with ADT, 34% died. The death rate among the whole group was 23%. Both percentages include both prostate cancer-specific and non-specific mortality.ConclusionAn advanced stage of disease at presentation mandates an early-detection, hospital-based screening programme. Further research should include many more patients and be based in several centres.

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“…9,10,13 Hormone therapy alone has been used successfully for some cases of multiple isolated pulmonary metastases. [14][15][16][17][18][19][20][21]…”

Section: Role Of Resection Of Pulmonary Metastases From Prostate Cancermentioning

confidence: 99%

The role of resection of pulmonary metastases from prostate cancer: a case report and literature review

Wallis

English

Goldenberg

2011

cuaj

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We report a case of a 53-year-old man who presented with two nodules in the lower lobe and one nodule in the upper lobe of the right lung almost 7 years after radical prostatectomy for pT3aN0M0, Gleason 4+5 disease, without evidence of osseous or lymphatic spread. Surgical resection of the lower lung nodules confirmed metastases, but prostate-specific antigen did not drop to undetectable levels. Isolated pulmonary metastases from prostate cancer are rare with only 33 previously described cases in the English-language literature, 18 of which were solitary metastases. We review the principles of management, including metastasectomy and long-term prognosis.

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Case study: management of advanced prostate cancer with soft tissue metastases

Cited by 6 publications

References 14 publications

Metastatic Prostate Cancer of Hand

Metastatic Prostate Cancer of Hand

An early-detection programme for prostate cancer in Saudi men: A call from a tertiary-care centre in the Eastern province

The role of resection of pulmonary metastases from prostate cancer: a case report and literature review

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