Case Study: An intraoperative finding of black bone disease in a podiatric surgery patient

Carter-Wale, Robyn L.; Prior, Trevor D

doi:10.1016/j.foot.2016.09.005

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Cited by 5 publications

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“…Due to its lipophilicity, minocycline can penetrate tissues readily. Given these characteristics, minocycline agents are commonly used in the long-term treatment for rheumatoid arthritis, rosacea, and acne [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Minocycline-induced black bone disease with synovial pigmentation in a patient undergoing revision anterior cruciate ligament surgery: A case report

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Chen

et al. 2021

International Journal of Surgery Case Reports

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Highlights Although hyperpigmentation is an extensively reported adverse effect of minocycline therapy in the oromaxillofacial region, bone discoloration remains a rare entity. This benign discoloration in bones is caused by chelation of the antibiotic with calcium ions or short polypeptides. Hyperpigmentation does not affect bone integrity, and surgical procedures can therefore be performed safely. Bone discoloration following long-term minocycline therapy is rare adverse effect.

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Section: Discussionmentioning

confidence: 99%