Case series of acute appendicitis association with SARS-CoV-2 infection

Prichard, Charlsea; Canning, Matthew; McWilliam-Ross, Kindra; Birbari, John; Parker, William A.; Wasson, Lori; Hollingsworth, John W.

doi:10.1186/s12879-021-05909-y

Cited by 8 publications

(21 citation statements)

References 7 publications

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“…35,42,43 Similar to some studies, but different from most studies, there was no increase in the frequency of complications in COVID-19-positive cases. 6,7,10,27,30,44,45 Although there was no increase in the complication prevalence, the frequency and level of fever and the mean length of hospital stay of COVID-19-positive patients in the pandemic period were higher than in the pre-pandemic period. Fever-related findings may be related to COVID-19 independent of AA.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Impact of the COVID‐19 pandemic and the restrictions on pediatric appendicitis in Turkey: A single‐center experience

Okur

Memetoğlu

Edirne

2022

Pediatrics International

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Background In this study, we investigated how the incidence and course of acute appendicitis (AA) changed in children, during the pandemic. Methods Children diagnosed with AA during the one‐year pandemic period after the first COVID‐19 case in Turkey and the previous one year were included in the study. Children were divided into two groups: those hospitalised during the pandemic (group A) and hospitalized in the previous year of the pandemic (group B). Furthermore, we compared the findings obtained for COVID‐19‐positive and COVID‐19‐negative children in the whole study group and within group A. Results In our study, a significant difference was found between the two groups in terms of gender, the rate of vomiting and number of days of vomiting. Complicated AA findings were found more frequently from the results of patients in group B than in group A. In addition, the hospital stay was longer, and the mean number of days with fever, and mean body temperature were higher in COVID‐19 positive patients in the whole study group and within group A. Conclusions Contrary to most studies in the literature, in our study patients were admitted to hospital later in the pre‐pandemic period, and therefore the frequency of complicated AA might have been more common in these patients. In conclusion, the arrangements and warnings of health authorities during the pandemic, might have reduced the anxiety and the hesitancy of the families to go to the hospital and relatively the rate of complicated acute appendicitis.

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Section: Discussionmentioning

confidence: 92%

“…Multisystem inflammatory syndrome in children (MIS‐C) should also be considered in children with prominent gastrointestinal symptoms and a history of recent COVID‐19 exposure or infection. Radiological examination and laboratory findings are necessary for differential diagnosis 6–9 …”

mentioning

confidence: 99%

Impact of the COVID‐19 pandemic and the restrictions on pediatric appendicitis in Turkey: A single‐center experience

Okur

Memetoğlu

Edirne

2022

Pediatrics International

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“…For example, a study by Prichard et al showed an increase in the number of appendicitis cases compared to the number of cases over the past three years. This is in conjunction with the likelihood of having clinically asymptomatic SARS-CoV-2 that is found on periprocedural testing which might suggest an association between SARS-CoV-2 and appendicitis [5]. Moreover, the pathophysiology of viral infections potentially causing appendicitis has been hypothesized to be related to lymphoid hyperplasia causing an appendicular obstruction which can be the underlying pathophysiology of SARS-CoV-2 infection possibly leading to appendicitis [6].…”

Section: Discussionmentioning

confidence: 99%

A Case of Complete Heart Block and Acute Appendicitis in a Young Patient With COVID-19

Sallam¹,

Sullivan²

2022

Cureus

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Recently, coronavirus disease 2019 (COVID-19, caused by SARS-CoV-2) has posed a challenge for clinicians, particularly extrapulmonary manifestations. These manifestations are often rare and difficult to recognize as research is still underway for the myriad presentations of the disease. A 19-year-old man presented with viral upper respiratory infection (URI) symptoms and received a positive result for SARS-CoV-2 real-time reverse transcription polymerase chain testing. A few days later, he developed abdominal pain and presented to the Emergency Department (ED). He was found to have bradycardia, right lower quadrant pain, fevers, and elevated inflammatory markers. An abdominal computed tomography scan showed appendicitis and an electrocardiogram showed third-degree heart block. He underwent successful implantation of a dualchamber permanent pacemaker and was scheduled for elective appendectomy. This case illustrates a state of system-wide inflammation that has been described mainly in pediatric patients with SARS-CoV-2 known as multisystem inflammatory syndrome in children (MIS-C). Recognition of this syndrome is crucial as it has potential diagnostic and therapeutic implications that can improve outcomes.

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“…prichard et al support an association between sars-CoV-2 and acute appendicitis. [7] patients with sars CoV 2 show a range of clinical manifestations ranging from mild to moderate to severe. Symptoms and signs are frequently non-specific, and they might conceal life-threatening diseases.…”

Section: Discussionmentioning

confidence: 99%

Is acute Appendicitis as an extra Pulmonary Manifestation of Covid-19 infection?

Muco¹,

Xhemali²,

Hasa³

et al. 2022

AJTES

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Background; Coronavirus disease-19 (COVID-19) is an infectious respiratory disease. The first confirmed case of 2019-nCoV infection in Albania was reported in Tirana on 08 March 2020, when a patient and his adult son who had come from Florence, Italy tested positive. Patients with COVID-19 can be presented with a series of signs and symptoms. Acute abdomen as a presentation of COVID-19 is rare. The diagnosis of COVID-19 should be suspected and investigated in every case of acute abdomen. Case presentation: We report a case of a 42-year-old male who presented with features of acute appendicitis. SARS-CoV-2 polymerase chain reaction test result was positive for COVID-19. Abdominal ultrasonography and his computed tomography of the chest and abdomen showed a perforated appendix and no infiltrates or abnormalities of COVID-19. The diagnosis of our case was appendicitis with COVID-19 without pneumonia. He was admitted and treated with antibiotic therapy and supportive care. He had an improvement in his health condition which made it possible to leave the hospital on the third day of hospitalization. Conclusion: Based on our clinical case and literature data, we suggest that clinicians should suspect the diagnosis of acute appendicitis in patients with COVID 19. So the case of acute abdomen pain must be completed with a SARS-CoV-2 test. Therefore we recommend additional studies to reinforce the idea of linking SARS COV 2 infection with acute appendicitis.

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Case series of acute appendicitis association with SARS-CoV-2 infection

Cited by 8 publications

References 7 publications

Impact of the COVID‐19 pandemic and the restrictions on pediatric appendicitis in Turkey: A single‐center experience

Impact of the COVID‐19 pandemic and the restrictions on pediatric appendicitis in Turkey: A single‐center experience

A Case of Complete Heart Block and Acute Appendicitis in a Young Patient With COVID-19

Is acute Appendicitis as an extra Pulmonary Manifestation of Covid-19 infection?

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