Case series of a single centre's treatment of ovulatory infertility with clomiphene citrate and intrauterine insemination in 2002

Costello, Michael; Emerson, Sandra; Miranda, Therese; Bakhtyari, Mo Bashir; Clements, Sarah; Hughes, Graeme J.; Steigrad, Stephen J.

doi:10.1111/j.1479-828x.2004.00191.x

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…The miscarriage rate at our center was 29% which was higher than that reported in other studies (20.96% by Guzick et al). The multiple pregnancy rate was only 4.3% in our study as compared to 7% reported by Costello et al 9 probably because a significant number of patients in our study with twin pregnancy miscarried. The ongoing pregnancy rate in our center was 5.6% which is comparable to the 6.7% ongoing pregnancy rate reported by Steures et al 4 .…”

Section: Discussioncontrasting

confidence: 87%

Intrauterine insemination experience in a government teaching hospital setup

Das

Pandey

Agarwal

et al. 2010

J Obstet Gynecol India

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Objectives: Intrauterine insemination with or without controlled ovarian hyperstimulation is a viable treatment option for male factor, cervical factor and unexplained infertility. We enumerate our 10 year experience in performing intrauterine insemination at a government teaching hospital setup. Study Design: Retrospective observational study. Results: Nine hundred eighty nine couples were observed for 3104 treatment cycles. Male factor and anovulation were the two common causes of infertility in this cohort. Out of the 232 pregnancies that occurred during the study, 34.05% resulted in live birth. Highest cycle fecundity was seen in cases of idiopathic infertility (16%) followed by male factor infertility (15%). 91.8% conceptions occurred in the 1st cycles of intrauterine insemination. Conclusion: In the resource deprived Indian scenario controlled ovarian hyperstimulation with intrauterine insemination is an effective, less invasive, feasible & financially acceptable modality for the treatment of sub-fertility.

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Section: Discussioncontrasting

confidence: 87%

Intrauterine insemination experience in a government teaching hospital setup

Das

Pandey

Agarwal

et al. 2010

J Obstet Gynecol India

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“…If all of the inclusion criteria were verified within the 12 months prior to initiation of participation, women were included. Women were excluded from the study when the inclusion criteria were not met, or if hormone supplementation (including clomiphene citrate13), in vitro fertilization or intrauterine insemination treatments were undertaken during the 6-month study period. Those women with minimal/mild endometriosis were included in the study, as were women over the age of 35 (age typically classified as the cutoff for high-risk pregnancies to develop).…”

Section: Methodsmentioning

confidence: 99%

Unexplained Infertility Treated with Acupuncture and Herbal Medicine in Korea

Park

Kang²,

Shin³

et al. 2010

The Journal of Alternative and Complementary Medicine

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Aim We aim to determine the safety and effectiveness of a standard therapeutic package of Korean medicine for the treatment of unexplained infertility in a cross-section of women who sought treatment at an integrative hospital in Seoul, Korea. Background Infertility affects more than 1.2 million women in the United States alone. Treatment options for infertility vary, yet the barriers of invasiveness, cost, and access inhibit treatment use for many women. Alternative medical approaches exist for this indication, and sustain certain popularity. Therefore, we systematically studied a standard therapeutic package of Korean medicine to treat unexplained infertility in women. Methods Female participants included in this observational study met inclusion criteria before receiving a set of treatments including herbal medicine, acupuncture, and moxibustion. A study physician screened each patient in accordance with inclusion criteria, provided study information, and after the patients consented, performed the baseline assessment. Assessments included age, the history of assisted reproductive technology, and duration of infertility. The key outcome measure included the number who achieved pregnancy and any neo-natal morbidity and mortality at follow-up stage for those who got pregnant. Any other adverse events including aggravation of existing symptoms, and the number of dropouts, were recorded. Treatments were supposed to be completed after 6 menstrual cycles between February 2005 and April 2006. Results One hundred and four (104) women with unexplained infertility were included in this observational study. Participant mean age was 32 years (SD: 2.7), with a range between 26 and 41 years. The median duration of infertility after diagnosis was 33.5 weeks (interquartile range: 20.8–50.3). In total, 41 participants (39.4%) had undergone a mean number of 1.4 (SD: 2.2) assisted reproductive technology treatments prior to joining the study. The number of patients remaining in or achieving pregnancy throughout the 6-month study period was 23 (14 pregnancies), 22.1%. Six (6) participants (4.8%) reported minor adverse events including rash in the face (n = 1), diarrhea (n = 2), dizziness (n = 1), and heartburn (n = 2). Of the 14 pregnancies, there were 10 normal births, and 4 miscarriages; otherwise, no neonatal morbidity/mortality occurred. According to per protocol analysis, 14 pregnancies out of 23 total were achieved by those who remained for the entire six menstruation cycle treatments, yielding a pregnancy rate of 60.9%. Conclusions The standard therapeutic package for unexplained infertility in women studied here is safe for infants and the treated women, when administered by licensed professionals. While it remains challenging to have the target population complete a 6-month treatment course, during which most patients have to pay out of pocket, the extent of successfully achieved pregnancy in those who received full treatment provides meaningful outcomes, warranting further attention. A future study that includ...

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“…Despite this negative effect, CC usually leads to pregnancy in approximately one-third of patients with ovulatory dysfunction undergoing a course of therapy (7). Unfortunately, there is a significant multiple pregnancy rate (PR), varying from 6%-11% (2,8,9).…”

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confidence: 97%