Case series: Congenital insensitivity to pain and anhidrosis

Rahalkar, Mukund D; Rahalkar, Anand M; Joshi, SK

doi:10.4103/0971-3026.40296

Cited by 6 publications

(3 citation statements)

References 5 publications

(6 reference statements)

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“…In patients with CIP, the pain stimulus is not properly transmitted to the central nervous system due to an alteration of the structure or function of the sensory pathways that becomes evident as abnormalities on NCS and nerve biopsy (1,(3)(4)(5)(6). Nevertheless, reports of CIP cases with normal NCS have been described (7)(8)(9)(10).…”

Section: Discussionmentioning

confidence: 95%

“…All patients discussed in the present report were diagnosed on the basis of clinical, electrophysiological, and histopathological findings to be suffering from congenital indifference to pain rather than CIP based on the evidence provided in previous reports (1,(3)(4)(5)(6). The patients were brought to the institute with complaints of self-biting, but they did not have siblings affected by the syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Congenital Indifference to Pain: A Report of Three Cases from Pakistan

Qureshi¹,

Ayaz²,

Khan³

et al. 2015

Turk J Phys Med Rehab

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Congenital indifference to pain is a rare disease defined by the failure to react to painful stimuli. Patients often present in early childhood with multiple self-inflicted injuries and damaged dentition. The response to other sensory modalities remains intact. Patients have normal nerve conduction and electromyography, as well as normal nerve biopsy. The disease is diagnosed after excluding congenital insensitivity to pain, fragile X-syndrome, syringomyelia, and pain asymbolia. Early diagnosis can reduce recurrent injuries and avoid unnecessary investigations. Here we present three patients with congenital indifference to pain who were referred to our institute for electrophysiological evaluation and found to have this disease.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Congenital Indifference to Pain: A Report of Three Cases from Pakistan

Qureshi¹,

Ayaz²,

Khan³

et al. 2015

Turk J Phys Med Rehab

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“…The deformity known as Charcot joint (neuropathic osteoarthropathy) 19 was observed in the left ankle due to repeated trauma. Similar finding was reported in other documented literature.…”

Section: Discussionmentioning

confidence: 99%

Congenital Insensitivity to Pain and Anhydrosis: Diagnostic and Therapeutic Dilemmas Revisited

Ravichandra¹,

Kandregula²,

Koya³

et al. 2015

International Journal of Clinical Pediatric Dentistry

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First described in 1932 by Dearborn as ‘congenital pure analgesia’, congenital insensitivity to pain and anhydrosis (CIPA) or hereditary sensory and autonomic neuropathy (HSAN) type IV is an extremely rare autosomal recessive disorder. A 7-year-old female child who is an established case of congenital insensitivity to pain and anhydrosis visited the department of pediatric medicine with osteoarthritic neuropathy. A multidisciplinary team approach was utilized to treat the child under general anesthesia. This article also discusses the diagnostic and therapeutic dilemmas involved in treating this type of children.How to cite this article: Ravichandra KS, Kandregula CR, Koya S, Lakhotia D. Congenital Insensitivity to Pain and Anhydrosis: Diagnostic and Therapeutic Dilemmas revisited. Int J Clin Pediatr Dent 2015;8(1):75-81.

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