Case reports: testicular pain as a manifestation of polyarteritis nodosa

Meeuwissen, Joris; Maertens, Johan; Verbeken, Eric; Blockmans, Daniel Engelbert

doi:10.1007/s10067-008-0970-5

Cited by 19 publications

(10 citation statements)

References 12 publications

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“…With evidence of neurological involvement, our patient was started on high-dose intravenous methylprednisone and cyclophosphamide with good effect. In this case, we also report successful conservative management with normal endocrine testicular function (Table 2) [6-9]. The facial weakness resolved after 3 months.…”

Section: Discussionmentioning

confidence: 73%

Polyarteritis Nodosa Presenting with Bilateral Testicular Swelling and Complicated by Unilateral Facial Nerve Palsy

et al. 2011

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Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that is generally restricted to medium-sized vessels. Here we describe the first case of a patient in which a bilateral testicular mass was a presenting symptom and the diagnosis was made on the basis of testicular histopathology. A 53-year-old Asian man presented with a history of constitutional symptoms and testicular swelling. Scrotal ultrasound revealed two avascular, bilateral, intratesticular lesions. The bilateral testicular abscess was treated without improvement. The patient developed left seventh cranial nerve palsy during his admission. The clinical changes made vasculitis or a related disorder more likely and the patient underwent a right testicular biopsy. Histopathology demonstrated features of transmural inflammation and fibrinoid necrosis of medium-sized vessel walls, consistent with PAN. This case illustrates the difficulty in diagnosing polyarteritis nodosa with isolated bilateral testicular swelling and the delay in the diagnosis. After 9 months of follow-up, no relapse had occurred and the patient's testosterone level was on the lower side of normal.

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Section: Discussionmentioning

confidence: 73%

Polyarteritis Nodosa Presenting with Bilateral Testicular Swelling and Complicated by Unilateral Facial Nerve Palsy

et al. 2011

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“…PAN commonly affects the kidneys, gastrointestinal tract, skin, nerves, joints, and muscles. PAN can also present as an isolated self-limited disorder, as in our case (9). It is a rare disease; in European countries the incidence ranges from 0 to 1.6 cases per million, and the prevalence is approximately 31 cases per million (10,11).…”

Section: Discussionmentioning

confidence: 77%

Sudden Death Due to Coronary Arteritis

Gabarrou

Guilbeau‐Frugier

Blanc

et al. 2017

Journal of Forensic Sciences

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We report the case of a middle-aged man, without medical history, who suddenly died at his workplace. The autopsy highlighted a pathological heart macroscopically, with multiple small white areas on the left myocardium. Coronary dissection revealed a pseudotumoural fibromyxoid aspect within the anterior interventricular artery (AIVA) and the left main coronary trunk, including reduction in their diameter with tight stenosis. Microscopic examination of these arteries showed fibroinflammatory wall destruction. In the left myocardium, there were multiple focal ischemic areas at different stages of recovery. Our case is an illustration of primary ischemic heart disease due to coronary arteritis, with a pseudotumoural presentation, which was revealed by sudden death. We discuss the cause of death and the etiological diagnosis preceding coronary arteritis.

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“…There have been several published case reports where testicular pain was the principal symptom/sign of PAN 3 4. The pathogenesis of the testicular pain is thought to be due to testicular artery vasculitis and this theory has been supported by ultrasonography of the testicles of patients with clinical evidence of PAN: Kolar et al demonstrated vasculitis of the testicular artery in a patient who was diagnosed with PAN 5.…”

Section: Discussionmentioning

confidence: 98%

Systemic vasculitis: a dual diagnosis?

Gil

Lutalo²,

D’Cruz³

2011

Case Reports

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The authors describe a 25-year-old male with systemic vasculitis fulfilling the American College of Rheumatology classification criteria for both granulomatosis with polyangiitis (Wegener's granulomatosis) and polyarteritis nodosa. The patient was diagnosed with granulomatosis with polyangiitis following a mediastinal biopsy which revealed necrotising granulomas of the large airways, a positive cytoplasmic antineutrophil cytoplasmic antibodies and high antiproteinase 3 antibody titre. He then developed acute right-sided abdominal and testicular pain as well as areas of hyperaesthesia and parasthesiae on both lower limbs. He was found to have focal crescentic glomerulonephritis and mononeuritis multiplex, in keeping with his diagnosis of granulomatosis with polyangiitis, as well as two areas of infarction in his right testicle and multiple aneurysms of his hepatic and right renal arteries, more typical of polyarteritis nodosa. His symptoms developed 6 weeks after hepatitis B vaccination, which may have played an aetiological role.

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Case reports: testicular pain as a manifestation of polyarteritis nodosa

Cited by 19 publications

References 12 publications

Polyarteritis Nodosa Presenting with Bilateral Testicular Swelling and Complicated by Unilateral Facial Nerve Palsy

Polyarteritis Nodosa Presenting with Bilateral Testicular Swelling and Complicated by Unilateral Facial Nerve Palsy

Sudden Death Due to Coronary Arteritis

Systemic vasculitis: a dual diagnosis?

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