Case Reports of a Giant Cell Reparative Granuloma and a Giant Cell Tumor on Temporal Bone

Dai, Wei-Ying; Tian, Chao; Liu, Li

doi:10.4103/0366-6999.240820

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…[51] Differential diagnosis e differential diagnosis of GCTB includes giant cell reparative granuloma, Paget's disease of the bone, aneurysmal cyst bone, chondroblastoma, chondromyxoid fibroma, nonossifying fibroma, fibrous dysplasia, pigmented villonodular synovitis, foreign body reactions, and brown tumors from hyperparathyroidism. [8,39,42,50] ese pathologies might be differentiated based on clinical history, laboratory tests, and imaging characteristics; nevertheless, a histopathological diagnosis is required. Although not pathognomonic, the common finding in a bone biopsy includes multiple multinucleated giant cells accompanied by ovoid-/spindleshaped stromal cells.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of giant cell tumor invading the occipital bone: A case report and literature review

Bocanegra-Becerra

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Tanta

2022

Surgical Neurology International

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Background: Giant cell tumor of bone (GCTB) rarely originates in the skull, particularly in the occipital bone. Although benign, it can severely destroy the surrounding tissue and undergo an unpredictable clinical course. We report the successful resection of a GCTB invading the occipital bone in a Hispanic adult woman and present a comprehensive review of the literature on this rare pathology by focusing on the occipital area. Case Description: A 40-year-old Hispanic woman presented with a 3-month history of neck pain and a bulging lesion on the retromastoid area. Brain magnetic resonance imaging (MRI) revealed an extradural, expansive, and contrast-enhancing lesion in the right occipital bone with multiple thin septa and evidence of bleeding. The patient underwent an uneventful gross total resection (GTR) of the lesion. The histopathological examination findings included numerous scattered osteoclast-type giant multinucleated cells. At a 10-month follow-up, the patient has not developed any neurological deficits, impairment of life functioning, or signs of recurrence in MRI. Conclusion: GCTB rarely originates in the skull, being the occipital bone the most infrequent site of presentation. When feasible, total surgical resection effectively reduces the risk of recurrence. Nonetheless, radiation and adjuvant therapies have been employed when GTR could not be achieved. A close follow-up with a brain MRI is advised to control recurrence.

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Section: Discussionmentioning

confidence: 99%

Surgical management of giant cell tumor invading the occipital bone: A case report and literature review

Bocanegra-Becerra

Showing

Tanta

2022

Surgical Neurology International

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“…Por muitos anos, a modalidade de tratamento de escolha tem sido a cirurgia, entretanto, a mesma é acompanhada muitas vezes de uma alta taxa de recidiva da lesão (cerca de 24%), e em GCCG agressivos e de grande extensão, essa forma de tratamento ocasiona um comprometimento estético e funcional, que necessita de grandes reabilitações cirúrgicas para devolver a estética e uma qualidade de vida aceitável ao paciente 3,7,8,13,17,18 .…”

Section: Revisão Da Literaturaunclassified

Comparação entre métodos cirúrgicos e conservadores para o tratamento de granuloma central de células gigantes descritos na literatura

Souza

Freitas

Santos

et al. 2022

R. Fac. Odontol. Porto Alegre

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Objetivo: Apresentar, através de uma revisão de literatura, métodos de tratamento do Granuloma mais conservadores, estabelecendo comparações entre estes, afim de fornecer à comunidade científica mais clareza e opções mais eficazes e seguras para o paciente. Revisão da literatura: O Granuloma Central de Células Gigantes (GCCG) é uma lesão proliferativa benigna intraóssea de etiologia incerta e comportamento clínico variável que possui como forma de tratamento mais utilizado os métodos cirúrgicos, entretanto, observou-se que os métodos cirúrgicos apresentam alta taxa de recidiva e um grande comprometimento estético e funcional. Em contrapartida, métodos mais conservadores mostram regressão completa da lesão e baixa taxa de recidiva, porém com a desvantagem de apresentar um longo período de tratamento e alguns efeitos adversos. Discussão: Ainda não existe um protocolo de gerenciamento de GCCG, seu manejo clínico deve levar em consideração a possibilidade de combinação de duas ou mais terapias objetivando melhores resultados. Conclusão: Os métodos conservadores são promissores por diminuir o tempo de tratamento e preservar a estética e função, além de ter a possibilidade de serem empregados juntos conforme a necessidade do paciente, apesar de nenhuma forma de tratamento individual ser a ideal.

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“…First described by Jaffe in 1953 (1), central giant cell granuloma (CGCG) is a very rare intraosseous benign lesion typically of the jaws, however more frequently occurring in the mandible than in the maxilla (2,3). Other regions like the skull base, ethmoid sinus or temporal bone are far less affected, respectively only reported in individual cases (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). The incidence of CGCG is reported with 1.1 to 1.97 per 10 6 (20,21) and a slightly higher frequency in females than males (1.25 vs. 1.05 per 10 6 ) (21).…”

Section: Introductionmentioning

confidence: 99%

Central giant cell granuloma of the temporal bone and temporo-mandibular-joint: a case report

Roth¹,

Meier²,

Ettl³

et al. 2022

Front Oral Maxillofac Med

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We present a seldom case of a patient with extended central giant cell granuloma (CGCG) of the temporal bone and temporomandibular joint representing a detailed example of diagnostical procedures, surgical approach, histological differentiation, treatment options and follow-up. In general, CGCG is a very rare benign osseous lesion of the jaws, more frequently occurring in the mandible than the maxilla. Other regions, such as skull base, ethmoid sinus or temporal bone, are far less common and only seldomly reported.Patients are usually younger than 30 years with a slightly higher occurrence rate in females than males.CGCG usually presents as unspecific incidental radiological finding or with unspecific clinical symptoms, e.g., indolent swelling. Lesions can show aggressive behaviour. Its aetiology remains unclear, syndromic occurrence is reported. Final diagnosis of CGCG is based on histopathological and molecular findings but remains difficult due to numerous differential diagnoses. Surgical therapy is the most common treatment, nevertheless other treatment modalities including several primary and adjuvant drug therapies, e.g., topical injection of steroids, systemic calcitonin, interferon-α, RANKL-inhibitors and tyrosine kinase inhibitors, as well as radiotherapy have been discussed with varying effects. Though, recurrence rates differ widely and range up to 72%. Due to the rarity of CGCG randomized controlled trials are still missing.

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Case Reports of a Giant Cell Reparative Granuloma and a Giant Cell Tumor on Temporal Bone

Cited by 5 publications

References 5 publications

Surgical management of giant cell tumor invading the occipital bone: A case report and literature review

Surgical management of giant cell tumor invading the occipital bone: A case report and literature review

Comparação entre métodos cirúrgicos e conservadores para o tratamento de granuloma central de células gigantes descritos na literatura

Central giant cell granuloma of the temporal bone and temporo-mandibular-joint: a case report

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