Case Report. Widespread tinea corporis due to <i>Trichophyton rubrum</i>

Gorani, A.; Schiera, A.; Oriani, A.

doi:10.1046/j.1439-0507.2002.00759.x

Cited by 8 publications

(3 citation statements)

References 10 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, there are few and conflicting data regarding predisposing genetic traits in chronic Tp ( Svejgaard et al, 1983 ; Ahmed et al, 1985 ). Although patients with CWD are frequently described in the literature ( Sentamilselvi et al, 1997–1998 ; Vittorio, 1997 ; Gorani et al, 2002 ; Cordeiro et al, 2006 ; Seyfarth et al, 2007 ; Balci and Cetin, 2008 ; Kong et al, 2015 ), it is not yet known why they are unable to mount CMI responses and resolve the infection. Our present findings may provide some clues to this issue.…”

Section: Discussionmentioning

confidence: 99%

“…CARD9 is an adaptor protein downstream to several immune receptors such as dectin-1, dectin-2, and mincle, which recognize fungal structures and are critical for antifungal Th-17 responses ( Lionakis and Holland, 2013 ). On the other hand, there are also frequent reports of patients presenting with recurrent or chronic widespread dermatophytosis (CWD) of the skin which, although not invasive, is difficult to manage ( Sentamilselvi et al, 1997–1998 ; Vittorio, 1997 ; Gorani et al, 2002 ; Cordeiro et al, 2006 ; Seyfarth et al, 2007 ; Balci and Cetin, 2008 ; Kong et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic widespread dermatophytosis due to Trichophyton rubrum: a syndrome associated with a Trichophyton-specific functional defect of phagocytes

et al. 2015

View full text Add to dashboard Cite

Dermatophytes are agents of typically benign superficial infections. However, an increasing number of severe infections in immunocompromised hosts has been reported. We aimed to understand the factors underlying the existence of a cohort of patients presenting with chronic widespread dermatophytosis (CWD) due to Trichophyton rubrum, but with no signs of immunodeficiency. Their disease is usually recurrent and difficult to manage. Fourteen patients meeting the following criteria for CWD were studied: T. rubrum culture-proven skin lesions of ≥10 cm in at least one dimension; the involvement of at least three non-contiguous localizations of >1 year’s duration; and no predisposing conditions. For comparison, we also studied 13 acute Tinea pedis patients. Macrophages and neutrophils were isolated and tested for T. rubrum conidia phagocytic and killing activity. H2O2, NO, and pro- and anti-inflammatory cytokine release were measured. All experiments were run with age- and sex-matched healthy donors’ cells in parallel. CWD patients’ macrophages and neutrophils presented with reduced T. rubrum–phagocytic and killing abilities, and reduced H2O2 and NO release when compared with those of healthy donors. CWD patients’ macrophages secreted lower levels of the proinflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α, but enhanced levels of the anti-inflammatory cytokine IL-10. Neutrophil secretion closely followed this unbalanced pattern. In contrast, responses to the positive controls zymosan, lipopolysaccharide, and phorbol myristate acetate were comparable with those of healthy donors. The same experiments were performed with macrophages and neutrophils from the acute Tinea pedis patients and showed no differences when compared with the matched healthy donors. Patients with CWD have a T. rubrum-related functional deficiency of phagocytes and may represent a distinct clinical entity in the complex spectrum of the Trichophyton–host interaction.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic widespread dermatophytosis due to Trichophyton rubrum: a syndrome associated with a Trichophyton-specific functional defect of phagocytes

et al. 2015

View full text Add to dashboard Cite

show abstract

“…While nea cruris presents at the groin, nea corporis may aff ect any other part of the body. 4 The diagnosis of superfi cial dermpatophytosis can be done by clinical examina on, potassium hydroxide examina on and fungal cultures. 5,6 Treatment of nea corporis and nea cruris varies according to the areas involved.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of neem seed extract compared with clotrimazole in tinea corporis/ cruris: A randomized controlled trial

Tianco

Villafuerte

2018

Nepal J Dermatol Venereol & Leprol

View full text Add to dashboard Cite

Introduction: Tinea corporis and tinea cruris are common superficial fungal infections. Neem (Azadirachta indica) seed extract has shown antifungal properties in vitro, but no clinical studies have been done for superficial dermatophytoses. This study compared the efficacy and safety of 5% neem seed extract in cream base with 1% clotrimazole cream when used twice daily for four weeks, in the treatment of localized tinea corporis and/or tinea cruris.Materials and Methods: This is a randomized, double blind, clinical trial. Patients with localized tinea corporis and/or tinea cruris were evaluated at baseline, week 1, week 2 and week 4. Clinical, mycological and effective cure rates of both treatment groups were determined. The patients’ post treatment overall satisfaction scores and the incidence of adverse effects were also documented.Results: Sixty patients were recruited, and 30 patients were randomized to each treatment arm. There were no significant differences in post treatment scores (p value=0.221). Effective cure, defined as the combination of marked clinical improvement and mycological cure, was seen in 20/30 (66.67%) in the neem seed extract group and 24/30 (80%) in the clotrimazole group (relative risk = 1.67, 95% confidence interval = 0.69 – 4.0). Post treatment overall satisfaction scores were comparable (p value = 0.333). Two patients experienced adverse effects in the neem seed extract group, while there were no adverse effects in the clotrimazole group.Conclusion: Efficacy and safety of 5% neem seed extract in cream base is comparable to 1% clotrimazole cream for the treatment of localized tinea corporis and/or tinea cruris.

show abstract

Chronically Recurrent and Widespread Tinea Corporis Due to Trichophyton rubrum in an Immunocompetent Patient

Kong

Yang

et al. 2014

Mycopathologia

View full text Add to dashboard Cite

A 31-year-old immunocompetent male who presented with a 4-year history of extensive erythematous and scaly plaques involving the abdomen, gluteal and inguen regions with concomitant tinea pedis and onychomycosis is described. Diagnosis was based on positive mycological examination and positive histopathologic examination. Species identification was performed by growth on Sabouraud dextrose agar and by sequencing of the internal transcribed spacer regions of the rDNA region. The pathogen identified was Trichophyton rubrum. The same fungal species was cultured from his abdominal, gluteal, foot and toenail. A combination therapy with systemic terbinafine and topically applied terbinafine cream was successful. A 1-year follow-up did not show any recurrence of infection.

show abstract

Case Report. Widespread tinea corporis due to Trichophyton rubrum

Cited by 8 publications

References 10 publications

Chronic widespread dermatophytosis due to Trichophyton rubrum: a syndrome associated with a Trichophyton-specific functional defect of phagocytes

Chronic widespread dermatophytosis due to Trichophyton rubrum: a syndrome associated with a Trichophyton-specific functional defect of phagocytes

Efficacy and safety of neem seed extract compared with clotrimazole in tinea corporis/ cruris: A randomized controlled trial

Chronically Recurrent and Widespread Tinea Corporis Due to Trichophyton rubrum in an Immunocompetent Patient

Contact Info

Product

Resources

About