Case report: Unique FLT4 variants associated with differential response to anlotinib in angiosarcoma

Gu, Yu; Meng, Jun; Ju, Yongzhi; You, Xiao; Sun, Tao; Lü, Jun; Yin, Geping

doi:10.3389/fonc.2022.1027696

Cited by 4 publications

(1 citation statement)

References 49 publications

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“…The results of the postoperative pathological examination confirmed the presence of a malignant tumor originating from the blood vessels, which was consistent with the diagnosis of PCA with lung metastasis. Due to the rarity of this disease, the lack of established treatment protocols and the presence of hemoptysis, targeted therapies commonly used for PCA, such as anlotinib [9][10][11] or pazopanib, [12] were not administered to the patient. Instead, based on the patient's symptoms and a review of relevant literature, we initiated treatment with paclitaxel (with albumin) monotherapy.…”

Section: Discussionmentioning

confidence: 99%

The diagnosis and treatment for primary cardiac angiosarcoma with N-ras gene mutation and MSI-L: A case report and review of the literature

Sun,

Wei,

Sun

et al. 2023

Medicine

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Rationale: Primary cardiac angiosarcomas (PCA) is a rare malignancy with a poor prognosis. Currently, there is no standard treatment protocol for the PCA. We report a case of PCA in a 51-year-old woman. Patient concerns: A 51-year-old woman initially presented with unexplained palpitations and chest tightness accompanied by nausea and vomiting, which worsened after activity and improved after rest. After symptomatic treatment, the symptoms improved, and the above symptoms recurred 8 months later. Diagnoses: Positron emission tomography-computed tomography revealed multiple lung nodules of varying sizes, some of which exhibited increased glucose metabolism. Furthermore, a soft tissue mass protruding into the pericardial cavity and involving the adjacent right atrium was observed in the right pericardium. The mass exhibited increased glucose metabolism, suggestive of a pericardial tumor with multiple lung metastases. Finally, histopathologic diagnosis of metastatic angiosarcoma was done by computed tomography-guided percutaneous lung and mediastinal biopsy. Interventions: The patient was treated with palliative chemotherapy for the primary cardiac angiosarcomas and hematogenous lung metastasis. One cycle later, the result of Next-Generation Sequencing showed that the microsatellite instability status was determined to be low-level. Based on this result, tislelizumab was added to the original chemotherapy regimen. Outcomes: Unfortunately, the patient with PCA passed away after only 2 cycles of chemotherapy, and the cause of death remained unknown. Lessons: This case report well demonstrates typical imaging findings of a rare cardiac angiosarcomas and emphasizes importance of early investigation for accurate diagnosis and proper management of the cardiac angiosarcomas.

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