Case report: Therapy-related myeloid neoplasms in three pediatric cases with medulloblastoma
Li Shun Mak,
Xiuling Li,
Wilson Y. K. Chan
et al.
Abstract:IntroductionMedulloblastoma is the most common malignant brain tumor in children, often requiring intensive multimodal therapy, including chemotherapy with alkylating agents. However, therapy-related complications, such as therapy-related myeloid neoplasms (t-MNs), can arise, particularly in patients with genetic predisposition syndromes. This case report presents three pediatric cases of medulloblastoma with subsequent development of t-MNs, highlighting the potential role of genetic predisposition and the imp… Show more
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