Case report: The computed tomographic appearances of benign hepatic hamartoma

Jennings, Christine; Merrill, C.R.; Slater, David

doi:10.1016/s0009-9260(87)80429-4

Cited by 11 publications

(7 citation statements)

References 10 publications

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“…The differential clinical, radiological and histopathological diagnosis of this entity may include many neoplastic and nonneoplasitc lesions. Radiologically, MHL as a cystic mass in liver may be included in the differential diagnosis of echinococcal disease and hepatic abscess 6,9,27. Because hydatid cysts are frequent in Turkey, the presumptive diagnosis in both of our patients was echinococcal disease.…”

Section: Discussionmentioning

confidence: 86%

“…Adulthood MHL is very rare, and 15 cases were reported in patients older than 18 years (range, 19 to 69 years) . A review of the reported cases is summarized in Table 2 ,…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] A review of the reported cases is summarized in Table 2. [4][5][6][9][10][11][12][13][14][15][16][17][18] In contrast to juvenile forms, adulthood cases were observed as symptomatic masses, more commonly in females. In other respects, MHLs of childhood and adulthood had no difference.…”

Section: Discussionmentioning

confidence: 99%

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Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients

Gürbüz

Turan

Zafer

et al. 2005

J Hepatobiliary Pancreat Surg

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Mesenchymal hamartoma is an uncommon cystic mass of the liver which occurs primarily in children. There are a few reports of its occurrence in adulthood. Here, we present two cases in female patients, 54 and 51 years old. Radiological examinations in both patients showed multiple cystic lesions in the liver. Surgically, total cystectomy was performed in the first patient, while an unroofing procedure was done in the second patient (due to misdiagnosis of the lesion as a simple cyst of the liver). On microscopic examinations of the lesion in each patient, a multilocular cyst was observed, lined by flattened epithelium and surrounded by a mesenchymal component composed of mature connective tissue, arterial and venous vascular structures, peripheral nerve bundles, and ductal structures. An immunohistochemical panel consisting of desmin, smooth-muscle actin, S-100, vimentin, CD34, carcinoembryonic antigen, pancytokeratin, cytokeratin 7, cytokeratin 8, cytokeratin 17, cytokeratin 18, cytokeratin 19, and cytokeratin 20 was applied to paraffin sections. Immunoreactivity for cytokeratin 7 and cytokeratin 19 was observed in cystic epithelium and ductal structures. Focal and patchy desmin immunoreactivity was observed in connective tissue. S-100 was positive only in peripheral nerve bundles. In conclusion, mesenchymal hamartoma of the liver in adulthood is a localized tumoral abnormality that precedes birth, and which has delayed clinical presentation. These lesions seems to be related to a maturation process. During this period of maturation, immature edematous stroma rich in mucopolysaccharides may convert to mature paucicellular hyalinized connective tissue. This maturation process may be also related to loss of premalignant potential of these tumors.

show abstract

Section: Discussionmentioning

confidence: 86%

“…Adulthood MHL is very rare, and 15 cases were reported in patients older than 18 years (range, 19 to 69 years) . A review of the reported cases is summarized in Table 2 ,…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients

Gürbüz

Turan

Zafer

et al. 2005

J Hepatobiliary Pancreat Surg

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“…9 The differential diagnosis must be expanded when a large cystic mass is present that does not arise definitively from the liver. The differential should include masses related to the gastrointestinal tract (atresia, duplication and mesenteric cysts), urinary system (renal origin, ureter, bladder, uraclms), ovary, omentum, and retroperitoneum (e.g., lymphangioma), as well as cystic teratoma (e.g., sacrococcygeal teratoma).…”

Section: Discussionmentioning

confidence: 99%

Prenatal evaluation of mesenchymal hamartoma of the liver: gray scale and power Doppler sonographic imaging

Bejvan

Winter²,

Shields³

et al. 1997

Journal of Ultrasound in Medicine

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“…Under 20 adult cases have been reported. [12][13][14][15][16][17][18][19][20][21][22][23][24] In all of these, there have been clear differences compared with the manifestations of the disease in childhood.…”

mentioning

confidence: 99%

Solid mesenchymal hamartoma in an adult: a case report

Hernández¹,

Catalano²,

González³

et al. 2006

J Clin Pathol

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Mesenchymal hamartoma of the liver (MHL) is an uncommon tumour composed of architecturally abnormal bile ducts in an uncommitted myxoid stroma. Most MHL are diagnosed in childhood and few cases have been reported in adults. This report describes a case of a well defined solid mass in the right lobe of the liver in a 51 year old man. Preoperative radiological examination revealed a large completely solid mass. Biopsy showed a dense fibrous stroma with hyalinisation and some bile ducts. A provisional diagnosis of MHL was made. Surgical excision was impossible and liver transplantation was undertaken. Definitive pathology confirmed the diagnosis. Review of published reports shows this to be the fourth case of MHL treated by liver transplantation.

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Case report: The computed tomographic appearances of benign hepatic hamartoma

Cited by 11 publications

References 10 publications

Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients

Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients

Prenatal evaluation of mesenchymal hamartoma of the liver: gray scale and power Doppler sonographic imaging

Solid mesenchymal hamartoma in an adult: a case report

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