Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures

Hong, Christopher S.; Gorrepati, Ramana; Kundishora, Adam J.; Elsamadicy, Aladine A.; Peter, Patricia; Damisah, Eyiyemisi; Manes, R. Peter; Omay, Sacit Bulent

doi:10.3389/fsurg.2020.598138

Cited by 3 publications

(9 citation statements)

References 11 publications

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“…Although many aspects of the molecular mechanisms of tumor invasion have been studied, the reasons for the aggressive growth of pituitary adenomas remain unclear [ 4 , 5 ]. The current study found that the main pathophysiology of invasive pituitary adenomas is a persistent state of cell proliferation and cell cycle disturbance [ 6 ]. Therefore, elucidating the molecular mechanism of invasive growth of invasive pituitary adenomas is particularly important for the prevention and treatment of invasive pituitary adenomas.…”

Section: Introductionmentioning

confidence: 99%

The AKT/mTOR Signaling Pathway Was Mediated through the LINC00514/miR-28-5p/TRIM44 Axis

et al. 2022

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Objective. Increasing evidence has demonstrated the essential role of lncRNAs in tumorigenesis. LINC00514, a novel lncRNA, was reported to be a promoter of malignant behaviors in cancer, but in pituitary adenoma (PA), its biological functions remain unclear. Methods. Herein, we measured LINC00514 expression by RT-qPCR analysis which indicated a significant elevation of LINC00514 expression in human PA tissues. Moreover, the effect of LINC00514 silencing on PA cell proliferation and invasion was, respectively, examined by CCK-8 and transwell assays. Results. The results showed that LINC00514 deletion markedly inhibited PA cell proliferation and invasion. Besides, investigation on the molecular mechanisms showed that LINC00514 might function as an endogenous RNA (ceRNA) to sponge miR-28-5p and TRIM44 was mediated by LINC00514-derived miR-28-5p in PA cells. Furthermore, the AKT/mTOR signaling pathway was mediated through the LINC00514/miR-28-5p/TRIM44 axis. Conclusion. To sum up, we suggested LINC00514 as a novel therapeutic target for PA treatment.

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Section: Introductionmentioning

confidence: 99%

The AKT/mTOR Signaling Pathway Was Mediated through the LINC00514/miR-28-5p/TRIM44 Axis

et al. 2022

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“…While visual impairments and visual field defects (72%), followed by headache (13%), are the commonest preoperative presentations of these entities, seizures, particularly of the generalized tonic clonic type, are extremely rare and limited to a handful of case reports. 3,6,[8][9][10][11][12] (Table 2) Convulsions are hypothesized to occur when the tumour invades the suprasellar area and/or the nervous system, specifically the frontal and temporal lobes, generating an epileptogenic focus. 4 However, it is important to note that seizures are increasingly common in patients with prolactinomas, specifically those treated with dopamine agonists such as cabergoline and bromocriptine, as discussed in depth through multiple case studies and case series.…”

Section: Discussionmentioning

confidence: 99%

“…9,13,14 This is speculated to be due to the intratumoural hemorrhage that occurs during the medical treatment of prolactinomas, hence acting as an instigator for seizure development, as supported by MRI evidence of hemosiderin deposition in the medial temporal lobes of those patients. 6 Nevertheless, the index case of GTC seizures from a GCNFPA histologically diagnosed as a null cell adenoma is unique both in its clinical presentation and the surgical management employed in its resection. Presentations of seizures much less seizures as the only complaint in non-functioning PitNETs are observed in a very limited number of case reports.…”

Section: Discussionmentioning

confidence: 99%

“…Presentations of seizures much less seizures as the only complaint in non-functioning PitNETs are observed in a very limited number of case reports. 3,6,12 Out of them all, a case report by Vakharia et al, 3 is closely related to the index case, which describes a 40year-old man presenting with new-onset generalized seizures to be investigated and diagnosed with a trilobed GCNFPA. Moreover, immunohistochemical findings of the previous case support the involvement of prolactin-producing tumour cells in the pathogenesis of this disease, providing direction for further research on this topic.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 However, seizure development in patients with pituitary pathologies in general is rare and usually associated either secondary to electrolyte abnormalities at presentation or a complication of medical treatment in the case of giant prolactinomas. 6 The first line management of giant pituitary adenomas except prolactinomas is surgery with the objective of safe resection while preserving neurological function. Different approaches such as transsphenoidal and transcranial are utilized but have been expanded with the introduction of endonasal endoscopic transsphenoidal surgery.…”

Section: Introductionmentioning

confidence: 99%

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Giant Clinically Non-Functioning Pituitary Adenoma Presenting as New Onset Generalized Tonic‒Clonic Seizures: A Case Report

Weerasekara,

Chandraratne,

Perera

2024

IMCRJ

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Background: Giant Clinically Non-Functioning Pituitary Adenomas (GCNFPA) are pituitary neuroendocrine tumours spanning beyond 4 cm in diameter without clinically apparent secretory function. They elicit insidious growth pertaining to its asymptomatic nature and present at large sizes from mass effect. Certain clinical features such as headache and visual disturbances are common presentations of GCNFPAs owing to their size, while others such as seizures are extremely rare. Case Report: A 63-year-old woman presented with back-to-back generalized tonic clonic seizures to the A&E and was treated with Levetiracetam. Following initial normal blood investigations, a visual field analysis revealed a bitemporal upper quadrantanopia and further evaluation using MRI found a giant pituitary lesion with suprasellar extension through the third ventricle into the lateral ventricles with significant mass effect. She underwent neuro-navigation guided endonasal transsphenoidal subtotal resection 2 weeks later. The histological diagnosis of null cell adenoma with a Ki67 of 3% was made. At 3 months of follow-up, she is symptom free and monitored with serial MRIs. Conclusion:Seizures are an uncommon presentation of GCNFPAs limited to a few case reports. This illustrates the importance of careful evaluation of patient presentations to correctly diagnose pituitary neoplasms and prioritizing symptom relief in choosing surgical approaches.

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Epilepsy associated with pituitary neuroendocrine tumors: Current status of problem and interdisciplinary approach

Василенко

Chudievich

Ulitin

et al. 2022

Medicinskij alfavit

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This literature review is devoted to the problem of epilepsy caused by pituitary neuroendocrine tumors: their detailed classification with the latest recommendations of the World Health Organization 2022, clinical picture of each variant of pituitary neuroendocrine tumor in a complex multidisciplinary approach are considered. The main feature of the review is a detailed consideration of the epilepsy associated with this condition, which is considered to be a rather rare manifestation of the disease (incidence in patients is 0.5 %), due to which very few cases of epilepsy in patients with pituitary adenoma have been described in the literature. Our work has analyzed the fundamental works of domestic scientists in this field, as well as current information from foreign sources and most of the available clinical cases of epilepsy in this group of patients, revealing in detail the pathogenesis of epilepsy at all levels, including molecular changes. Modern techniques for the treatment approach in this group of patients are also described, the effectiveness of drug and surgical therapy is analyzed according to the criteria of the frequency of long-term persistent remission and recurrence, side effects of drugs and complications of transsphenoidal tumor resection are reviewed, including in terms of possible epilepsy; conclusions about the most rational and effective approach to treatment of various types of hypophysial neuroendocrine tumors are drawn.

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Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures

Cited by 3 publications

References 11 publications

The AKT/mTOR Signaling Pathway Was Mediated through the LINC00514/miR-28-5p/TRIM44 Axis

The AKT/mTOR Signaling Pathway Was Mediated through the LINC00514/miR-28-5p/TRIM44 Axis

Giant Clinically Non-Functioning Pituitary Adenoma Presenting as New Onset Generalized Tonic‒Clonic Seizures: A Case Report

Epilepsy associated with pituitary neuroendocrine tumors: Current status of problem and interdisciplinary approach

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