Case Report: Spontaneous simultaneous coronary and carotid dissection in a young cannabis user

Amor, Hassen Ibn Hadj; Touil, I.; Boukriba, Seif; Bouchnak, Skander; Kraiem, Salma; Rouabhia, Ramzi

doi:10.12688/f1000research.52606.2

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…There were 23 studies identified that included patients presenting with cannabis induced ischemic stroke [ Table 4 ]. [ 3 , 6 , 11 , 16 , 17 , 19 , 21 , 27 , 29 , 39 , 44 , 50 , 57 - 59 , 61 , 63 , 64 , 67 - 69 , 71 , 72 ] Demographic information was available in 22 articles for a total of 44 patients (10/44 [23%] female) with a median age of 28 years. All included studies described clinical presentation for the 184 total patients, which consisted of headache (2%), speech disturbance (64%), abnormal sensation/ motor function (38%), and visual disturbance (14%).…”

Section: Resultsmentioning

confidence: 99%

Effect of drug use in the treatment of acute ischemic stroke: A scoping review

Dabhi¹,

Mastorakos²,

Sokolowski³

et al. 2022

Surgical Neurology International

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Background: Drugs of abuse have been associated with ischemic stroke; however, the clinical presentation, outcomes, and treatment data in this population are limited. The overall safety and efficacy of thrombolytic therapy and thrombectomy in these patients remain unclear. This scoping review summarizes published complications and clinical outcomes in patients with recent abuse of cocaine, methamphetamine (MA), cannabis, decongestant, opioids, alcohol, and 3,4-methylenedioxymethamphetamine (MDMA) presenting with acute ischemic stroke. Methods: We conducted a scoping review of the primary literature that assessed outcomes data of thrombolytic therapy or thrombectomy in drug users with acute ischemic stroke. We searched PubMed, Ovid Medline, and Web of Science. Demographic and stroke characteristics, treatment, complications, and clinical outcomes at last follow-up were collected and summarized. Results: We identified 51 studies in this review. Drugs of abuse of interest were cocaine (14 studies), MDMA (one study), MA (eight studies), cannabis (23 studies), alcohol (two studies), decongestants (one study), and opioids (two studies). Clinical presentation and stroke presentation were most commonly described features. Thrombectomy outcomes were reported for four patients total (two studies), all with history of cocaine use. Thrombolysis treatment and outcomes were reported for 8851 patients (five studies) with history of cocaine, alcohol, or cannabis. Both treatments were pursued in three patients (three studies). Treatment complications included intracerebral hemorrhage, vasospasm, and cerebral edema. Conclusion: Evidence for thrombolytic and thrombectomy treatment in drug users remains limited. Controlled studies are needed to examine complication profile and outcomes following thrombolytic and thrombectomy treatment in this population.

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Section: Resultsmentioning

confidence: 99%

Effect of drug use in the treatment of acute ischemic stroke: A scoping review

Dabhi¹,

Mastorakos²,

Sokolowski³

et al. 2022

Surgical Neurology International

View full text Add to dashboard Cite

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Dissecting the role of cannabinoids in vascular health and disease

Guo,

Wei,

Pei

et al. 2024

Journal Cellular Physiology

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Cannabis, often recognized as the most widely used illegal psychoactive substance globally, has seen a shift in its legal status in several countries and regions for both recreational and medicinal uses. This change has brought to light new evidence linking cannabis consumption to various vascular conditions. Specifically, there is an association between cannabis use and atherosclerosis, along with conditions such as arteritis, reversible vasospasm, and incidents of aortic aneurysm or dissection. Recent research has started to reveal the mechanisms connecting cannabinoid compounds to atherosclerosis development. It is well known that the primary biological roles of cannabinoids operate through the activation of cannabinoid receptor types 1 and 2. Manipulation of the endocannabinoid system, either genetically or pharmacologically, is emerging as a promising approach to address metabolic dysfunctions related to obesity. Additionally, numerous studies have demonstrated the vasorelaxant properties and potential atheroprotective benefits of cannabinoids. In preclinical trials, cannabidiol is being explored as a treatment option for monocrotaline‐induced pulmonary arterial hypertension. Although existing literature suggests a direct role of cannabinoids in the pathogenesis of atherosclerosis, the correlation between cannabinoids and other vascular diseases was only reported in some case series or observational studies, and its role and precise mechanisms remain unclear. Therefore, it is necessary to summarize and update previously published studies. This review article aims to summarize the latest clinical and experimental research findings on the relationship between cannabis use and vascular diseases. It also seeks to shed light on the potential mechanisms underlying these associations, offering a comprehensive view of current knowledge in this evolving field of study.

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Case Report: Spontaneous simultaneous coronary and carotid dissection in a young cannabis user

Cited by 2 publications

References 14 publications

Effect of drug use in the treatment of acute ischemic stroke: A scoping review

Effect of drug use in the treatment of acute ischemic stroke: A scoping review

Dissecting the role of cannabinoids in vascular health and disease

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