Case report: Rift Valley Fever with vertical transmission in a pregnant Sudanese woman

Adam, Ishag; Karsany, Mubarak S

doi:10.1002/jmv.21132

Cited by 70 publications

(56 citation statements)

References 5 publications

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“…During the outbreak, a serious case of vertical transmission from mother to the baby was documented [41], similar to a previously reported case in Saudi Arabia in 2000 [42]. Many maternal deaths were observed in Central Sudan during the RVF outbreak [41], consistent with the claims recently made about the burden of emerging zoonotic infectious disease among women in general, and pregnant women in particular [43].…”

Section: Risk Factors For Severe Rvfv Infectionsupporting

confidence: 82%

The 2007 Rift Valley Fever Outbreak in Sudan

et al. 2011

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Rift Valley fever (RVF) is a neglected, emerging, mosquito-borne disease with severe negative impact on human and animal health and economy. RVF is caused by RVF virus (RVFV) affecting humans and a wide range of animals. The virus is transmitted through bites from mosquitoes and exposure to viremic blood, body fluids, or tissues of infected animals. During 2007 a large RVF outbreak occurred in Sudan with a total of 747 confirmed human cases including 230 deaths (case fatality 30.8%); although it has been estimated 75,000 were infected. It was most severe in White Nile, El Gezira, and Sennar states near to the White Nile and the Blue Nile Rivers. Notably, RVF was not demonstrated in livestock until after the human cases appeared and unfortunately, there are no records or reports of the number of affected animals or deaths. Ideally, animals should serve as sentinels to prevent loss of human life, but the situation here was reversed. Animal contact seemed to be the most dominant risk factor followed by animal products and mosquito bites. The Sudan outbreak followed an unusually heavy rainfall in the country with severe flooding and previous studies on RVF in Sudan suggest that RVFV is endemic in parts of Sudan. An RVF outbreak results in human disease, but also large economic loss with an impact beyond the immediate influence on the directly affected agricultural producers. The outbreak emphasizes the need for collaboration between veterinary and health authorities, entomologists, environmental specialists, and biologists, as the best strategy towards the prevention and control of RVF.

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Section: Risk Factors For Severe Rvfv Infectionsupporting

confidence: 82%

The 2007 Rift Valley Fever Outbreak in Sudan

et al. 2011

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“…In animals, RVFV has been shown to be present in the visceral organs and brains of aborted and malformed fetuses (9), and a case of human vertical RVF transmission was recently described (1). Even though we have no direct evidence that the induction of nuclear anomalies, observed here in murine fibroblasts as well as in sheep kidney cells of fetal origin, leads to abortion and teratogenesis, it is reasonable to postulate that an abnormally high accumulation of defects in chromosome cohesion and segregation during embryonic development could at least partly account for the high rate of abortions and teratogenic disorders predominantly observed after RVFV infection among ovines.…”

Section: Discussionmentioning

confidence: 99%

Nonstructural NSs Protein of Rift Valley Fever Virus Interacts with Pericentromeric DNA Sequences of the Host Cell, Inducing Chromosome Cohesion and Segregation Defects

Mansuroglu

Josse

Gilleron

et al. 2010

J Virol

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Rift Valley fever virus (RVFV)is an emerging, highly pathogenic virus; RVFV infection can lead to encephalitis, retinitis, or fatal hepatitis associated with hemorrhagic fever in humans, as well as death, abortions, and fetal deformities in animals. RVFV nonstructural NSs protein, a major factor of the virulence, forms filamentous structures in the nuclei of infected cells. In order to further understand RVFV pathology, we investigated, by chromatin immunoprecipitation, immunofluorescence, fluorescence in situ hybridization, and confocal microscopy, the capacity of NSs to interact with the host genome. Our results demonstrate that even though cellular DNA is predominantly excluded from NSs filaments, NSs interacts with some specific DNA regions of the host genome such as clusters of pericentromeric ␥-satellite sequence. Targeting of these sequences by NSs was correlated with the induction of chromosome cohesion and segregation defects in RVFV-infected murine, as well as sheep cells. Using recombinant nonpathogenic virus rZH⌬NSs210-230, expressing a NSs protein deleted of its region of interaction with cellular factor SAP30, we showed that the NSs-SAP30 interaction was essential for NSs to target pericentromeric sequences, as well as for induction of chromosome segregation defects. The effect of RVFV upon the inheritance of genetic information is discussed with respect to the pathology associated with fetal deformities and abortions, highlighting the main role played by cellular cofactor SAP30 on the establishment of NSs interactions with host DNA sequences and RVFV pathogenesis.

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“…During the recent 2007-2008 Sudanese outbreak, preterm labor due to acute RVF disease was also found to result in delivery of an anti-RVFV IgM positive baby with skin rash and hepatosplenomegaly, again suggesting that vertical transmission of RVFV probably does occur among humans [34]. …”

Section: Human Rvf Diseasementioning

confidence: 99%

Advances in Rift Valley fever research: insights for disease prevention

LaBeaud¹,

Kazura²,

King

2010

Current Opinion in Infectious Diseases

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Purpose of review The purpose of the study was to review recent research on Rift Valley fever virus (RVFV) infection, encompassing four main areas: epidemiology and outbreak prediction, viral pathogenesis, human diagnostics and therapeutics, and vaccine and therapeutic candidates. Recent findings RVFV continues to extend its range in Africa and the Middle East. Better definition of RVFV-related clinical syndromes and human risk factors for severe disease, combined with early-warning systems based on remote-sensing, simplified rapid diagnostics, and tele-epidemiology, hold promise for earlier deployment of effective outbreak control measures. Advances in understanding of viral replication pathways and host cell-related pathogenesis suggest means for antiviral therapeutics and for more effective vaccination strategies based on genetically engineered virus strains or subunit vaccines. Summary RVFV is a significant health and economic burden in many areas of Africa, and remains a serious threat to other parts of the world. Development of more effective methods for RVFV outbreak prevention and control remains a global health priority.

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Case report: Rift Valley Fever with vertical transmission in a pregnant Sudanese woman

Cited by 70 publications

References 5 publications

The 2007 Rift Valley Fever Outbreak in Sudan

The 2007 Rift Valley Fever Outbreak in Sudan

Nonstructural NSs Protein of Rift Valley Fever Virus Interacts with Pericentromeric DNA Sequences of the Host Cell, Inducing Chromosome Cohesion and Segregation Defects

Advances in Rift Valley fever research: insights for disease prevention

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