Case Report: Response to Intra-arterial Cisplatin and Concurrent Radiotherapy Followed by Salvage Surgery in a Patient With Advanced Primary Sinonasal Low-Grade Non-intestinal Adenocarcinoma

Tachino, Hirohiko; Takakura, Hiroyuki; Shojaku, Hideo; Fujisaka, Michiro; Akaogi, Katsuichi; Kawabe, Hideto; Naruto, Norihito; Shojaku, Hiroko; Noguchi, Kyo; Miwa, Satoshi; Imura, Johji; Maeda, Yoshinobu

doi:10.3389/fsurg.2020.599392

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…LG non-ITAC is very rare, and the report by Tachino et al is the only one in the literature on the clinical and therapeutic characteristics of LG non-ITAC in Japan. 1 Consequently, this is the second reported case ( Table 1 ). LG non-ITAC is observed in a wide range of age groups and primarily develops in the nasal cavity or paranasal sinuses, such as the ethmoidal and maxillary sinuses.…”

Section: Discussionmentioning

confidence: 75%

“…At present, however, there is no established pharmacotherapy for LG non-ITAC. 1 The 5-year survival rate of LG non-ITAC is good at !80%. On the other hand, HG non-ITAC is characterized by rapid tumor progression, and the 3-year survival rate is approximately 20%.…”

Section: Discussionmentioning

confidence: 99%

“…A white polypoid lesion with a smooth surface was observed in the left middle nasal meatus (►Fig. 1).…”

Section: Findings At the Initial Examinationmentioning

confidence: 99%

“…LG non-ITAC is very rare, and to date, there is only one published report on the clinical and therapeutic characteristics of LG non-ITAC in Japan. 1 We report the case of a woman who was diagnosed with sinonasal LG non-ITAC at our hospital.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Sinonasal Low-Grade Nonintestinal Adenocarcinoma That Was Difficult to Diagnose Preoperatively

Mizoguchi,

Tanaka,

Kikuchi

2023

International Journal of Practical Otolaryngology

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We report a case of sinonasal low-grade, nonintestinal adenocarcinoma (LG non-ITAC). The patient, a 56-year-old woman, was referred to our university hospital for a left nasal tumor with nasal obstruction, epistaxis, and nasal discharge. Nasal endoscopy revealed a nasal polypoid tumor with a smooth margin occupying the left nasal cavity. The sinonasal tumor was diagnosed as an exophytic papilloma by histopathology. Sinonasal contrast computed tomography (CT) confirmed homogeneous opacification of the left frontal, maxillary, and ethmoidal sinuses. There was no evidence of a potential bone defect. T2-weighted magnetic resonance imaging (MRI) showed a relatively uniform high signal intensity area in the left maxillary and frontal sinuses. An area of high signal intensity was also found in a part of the left ethmoid sinus. Left transnasal endoscopic ethmoidectomy was performed under general anesthesia. The tumor in the nasal cavity was prone to bleeding. We defined the site of tumor attachment as the suprabullar cell. The anterior ethmoidal artery was exposed, and the tumor was carefully dissected and removed. Based on the findings of these radiological and histological examinations, the sinonasal tumor was diagnosed as a LG non-ITAC. Sinonasal non-ITAC is an adenocarcinoma without the histopathological characteristics of salivary or intestinal-type adenocarcinoma. Non-ITAC is additionally classified into the high-grade and LG types. LG non-ITAC is very uncommon. Thus far, there is only one published report in the literature on the clinical and therapeutic characteristics of LG non-ITAC in Japan. Non-ITAC has a good prognosis, with a low risk of metastasis. Therefore, it is imperative to suspect and distinguish non-ITAC from other sinonasal tumors with similar symptoms preoperatively.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

“…A white polypoid lesion with a smooth surface was observed in the left middle nasal meatus (►Fig. 1).…”

Section: Findings At the Initial Examinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Case of Sinonasal Low-Grade Nonintestinal Adenocarcinoma That Was Difficult to Diagnose Preoperatively

Mizoguchi,

Tanaka,

Kikuchi

2023

International Journal of Practical Otolaryngology

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A case of sinonasal low-grade non-intestinal-type adenocarcinoma

et al. 2023

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We present the case of a patient with low-grade non-intestinal-type adenocarcinoma (non-ITAC) of the nasal cavity, which is a very rare tumor. A 62-year-old female visited another hospital due to nasal obstruction on the left side. Adenocarcinoma of the nasal cavity was suspected, and she visited our department for detailed examination and treatment. A tumor was observed from the left inferior meatus to the common nasal meatus. Contrast-enhanced CT/MRI showed a neoplastic lesion with a mild contrast-enhancing effect localized in the nasal cavity. Under the diagnosis of left nasal adenocarcinoma cT1N0M0, we performed endoscopic tumor resection under general anesthesia. Histopathologic examination of the tumor showed low-grade non-ITAC. The margins were negative and no additional treatment was performed. No local recurrence or metastasis was observed 12 months postoperatively.

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