Case report: Pulmonary blastoma in children—response to chemotherapy

Lobo-Sanahuja, F; García, I. Formoso; Santamaría, Silvia Santamaría; Barrantes, José

doi:10.1002/(sici)1096-911x(199603)26:3<196::aid-mpo9>3.0.co;2-f

Cited by 10 publications

(3 citation statements)

References 18 publications

(6 reference statements)

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“…Based on these reports and our case study, clinicopathological features of PB are listed in Table 1. [13][14][15][16][17][18][19][20][21][22][23][24][25] According to these cases, neonates to 18-yearold patients represent common respiratory tract symptoms, except for one patient who was symptom-free. The right lung is more frequently affected by PB than the left, which is consistent with a previous study involving adult patients.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Blastoma in Children: Report of a Rare Case and Review of the Literature

et al. 2017

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Pulmonary blastoma is a rare malignant lung tumor with aggressive behavior and dismal prognosis. It is extremely rare in children aged <18 years, and little is known about its genetic alteration and pathogenesis. Although surgical resection and adjuvant chemotherapy or radiotherapy have been applied in several cases, no standard treatment guidelines with sufficient evidence have been established. In this article, we report a case of a large pulmonary blastoma in a 7-year-old girl whose initial presentation was progressive dyspnea and productive cough. We subsequently present a review on cases involving young patients as well as genetic analysis data available in the literature.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Blastoma in Children: Report of a Rare Case and Review of the Literature

et al. 2017

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“…Also Lobo-Sanahuja et al [5] in 1996 used a preoperative combination chemotherapy consisting of cisplatin, etoposide alternating with ifosphamide with mesna, vincristine and epirubicine resulted in an objective response that permitted subsequent safe sur-gical excision of the primary tumor.…”

Section: Discussionmentioning

confidence: 99%

Pleuropulmonary blastoma is a rare malignancy in young adult and childhood

Zareifar

Karimi

Tasbihi

et al. 2015

Korean J Clin Oncol

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Case 1 A 3.5-year-old girl presented with 3 week history of shortness of breath, non-productive cough, fever and right-sided non-pleuritic chest pain. She was taken two courses of oral antibiotics but without any improvement. She was previously fit and well without history of exposure to second hand smoking. Initial investigations showed normal complete blood counts, liver and kidney function tests. Serum electrolytes and urine analysis were also normal. Chest radiography revealed complete opacification of the right hemithorax, contralateral mediastinal shifting consistent with right sided large pleural effusion (Fig. 1). Contrast enhanced chest computed tomography scan (CT scan) confirmed large right pleural effusion with associated mediastinal shift and complete right lung collapse. No abnormality was reported in the left hemithorax or upper abdomen. Right thoracotomy and decortication revealed large un-resectable masses with adherent deposits on the diaphragm and enlarged pericardial lymph nodes. The right middle lobe was obliterated. Multiple biopsies were taken from tumor and lymph nodes. Pleural fluid analysis demonstrated an exudative pattern. Bone marrow aspiration and biopsy were normal.Due to her critical condition with suspicion of primitive neuroec-

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“…Bei Fall 2 aus unserem Krankengut konnte die intraoperative Tumorruptur mit Aussaat der entarteten Zellen in die Thoraxhö hle trotz hö chster Sorgfalt nicht vermieden werden. Bis jetzt liegen 2 Berichte ü ber eine erfolgreiche prä operative chemotherapeutische Tumorverkleinerung vor [21,28]. Wie Calabria et al [7] konnten wir jedoch durch postoperative Chemo-und Strahlentherapie bei Fall 1 eine langfristige Remission ohne Hinweise auf Tumorprogression erreichen.…”

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