Case Report: Primary melanoma of the gastroesophageal junction

Agha, Yasmine Hussein; Parker, Nathaniel; Alderson, Joel

doi:10.12688/f1000research.24302.1

Cited by 4 publications

(6 citation statements)

References 18 publications

(24 reference statements)

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“…По всему миру было описано не более 400 случаев, большинство из которых представляют собой клинические наблюдения [4]. ПМП преимущественно встречается у мужчин (соотношение мужчин и женщин составляет примерно 1,6-2:1) в возрасте 60-70 лет, несколько чаще среди населения Японии [5]. Опухоль преимущественно локализуется в средней и нижней трети пищевода.…”

Section: первичная меланома пищеводаunclassified

Primary Esophageal Melanoma

Sutyagin¹,

Shchelochenkov²,

Guskova³

et al. 2021

EPh

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Primary esophageal melanoma is an extremely rare malignancy with an estimated prevalence of 0.0036 cases per million per year. The prognosis of the disease is unfavorable, in 30-40% of patients metastases are detected at the time of diagnosis, generally accepted approaches to treatment are currently insufficiently developed. The article presents the review of the literature and describes the clinical case of a patient with primary esophageal melanoma

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Section: первичная меланома пищеводаunclassified

Primary Esophageal Melanoma

Sutyagin¹,

Shchelochenkov²,

Guskova³

et al. 2021

EPh

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“…Ishizaki et al ( 9 ) reported a primary malignant melanoma of the esophagogastric junction: the patient was misinterpreted as undifferentiated carcinoma or malignant lymphoma preoperatively and died 11 months after the stomach operation due to multiple metastases. In another similar case ( 3 ), the patient died two months after hospital dismissal. Herein, we report a case of primary gastroesophageal junction melanoma with local lymph node metastasis in an elder Chinese woman.…”

Section: Introductionmentioning

confidence: 96%

“…Mucosal melanoma accounts for less than 1.5% of all melanomas ( 2 ), with only 1% and 0.5% growing in stomach and esophagus in all non-cutaneous melanoma respectively. Primary mucosal malignant melanoma (PMMM) located in the gastroesophageal junction is even rarer, and up to 2020, there are only 7 similar cases ( 3 ). However, once rooted in the esophagus or gastrointestinal tract, the probability of occurrence is small but the possibility of metastasis becomes high ( 4 - 6 ).…”

Section: Introductionmentioning

confidence: 99%

Primary malignant melanoma in gastroesophageal junction with 36 months’ recurrence-free: a case report

Dai¹,

Zhang²,

Chen³

et al. 2022

AME Case Rep

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Background Melanoma is a sinister malignant tumor originates from melanocytes and is characterized by the presence of black pigmentation in the tissue. The vast majority of melanomas are cutaneous melanomas, and primary mucosal melanomas originating from the esophagus are extremely rare. Primary malignant melanoma of esophagus (PMME) accounts for 0.1% to 0.2% of all primary esophageal malignancies. PMME possess high invasiveness but are insensitive to various treatments, so the prognosis is disappointing. Most literature reported that patients are prone to death from complications of tumor metastasis soon, even they undergo radical surgery. Case Description In this case report, we admitted a 67-year-old female patient with recurrent chest tightness for 2 years and chest pain for 15 days on October 4, 2017. Preoperative imaging examinations, including computerized tomography (CT) and upper gastrointestinal examination by barium revealed stenosis of the lower esophagus and the fundus of the stomach, with mucosa destruction and lymph node metastasis in the hepatic-gastric space. A laparoscope assisted total gastrectomy with D2 lymph node resection and Roux-en-Y anastomosis was performed without adjuvant immunotherapy or targeted therapies. Postoperative pathological examination and immunohistochemical staining indicated malignant melanoma. Meanwhile we did not find a cutaneous lesion, this patient was therefore diagnosed with a rare PMME. There was no sign of recurrence or metastasis during the latest follow-up of 36 months after the operation, which also exceeded the median recurrence-free survival time in the existing cases worldwide. Conclusions Therefore, we recommend early radical surgery, which may be beneficial to the PMME patient.

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“…Malignant melanoma is a disease with poor prognosis that develops from melanocytes of the skin, oral cavity, nasal cavity, pharynx, uvea, and rectum. Primary melanoma of the gastrointestinal tract is rare [ 1 – 3 ], particularly in patients with melanoma esophagogastric junction of which there has been few case reports [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…melanoma of the gastrointestinal tract is rare [1][2][3], particularly in patients with melanoma esophagogastric junction of which there has been few case reports [4,5].…”

mentioning

confidence: 99%

A case of primary malignant melanoma of the esophagogastric junction with abscopal effect after nivolumab administration

et al. 2021

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Background The abscopal effect is a rare phenomenon in which local irradiation causes tumor regression outside the irradiated area. There have been no reports of abscopal effect in patients with gastrointestinal melanoma with metastasis. Here, we report a case of primary malignant melanoma of the esophagogastric junction with abscopal effect after long-term treatment with nivolumab. Case presentation A 75-year-old woman was referred to our hospital with a gastroesophageal lesion. Upper gastrointestinal endoscopy revealed a raised lesion on the posterior wall of the greater curvature of the cardia and tenderness in the lower esophagus. Immunostaining of the tumor biopsy showed positive staining for Melan-A, human melanoma black-45 (HMB45), and S-100, indicating malignant melanoma of the esophagogastric junction. Contrast-enhanced computed tomography (CT) of the abdomen showed a mildly stained lesion protruding into the cardiac part of stomach and enlarged surrounding lymph nodes. The patient was diagnosed with malignant melanoma of the esophagogastric junction and proximal gastrectomy with lower esophagus resection was performed. Histological examination showed large, round tumor cells with nuclear atypia. Immunostaining was positive for Melan A, HMB45, S-100 protein, and SRY-box transcription factor 10, and the final diagnosis was malignant melanoma of the esophagogastric junction, with regional lymph node metastases. Three months after surgery, follow-up CT indicated left pleural metastasis; therefore, the patient was administered nivolumab, an immune checkpoint inhibitor (ICI). Following three courses of nivolumab, the patient exhibited grade 3 renal dysfunction (Common Terminology Criteria for Adverse Events version 5.0). After that, we have not administered nivolumab treatment. Five months after the development of renal dysfunction, a CT scan demonstrated an unstained nodule within the pancreatic, and the patient was diagnosed with pancreatic metastasis; intensity-modulated radiotherapy was performed. Six months later, CT revealed pancreatic nodule and pleural metastasis was shrunk; after an additional 2 months, pleural metastasis and effusion had disappeared. The patient is alive with no additional lesions. Conclusions We report a case of primary malignant melanoma of the esophagogastric junction with an abscopal effect following nivolumab treatment. The findings of this case report suggest that ICIs in combination with radiotherapy may be effective for treating metastatic or recurrent malignant melanoma of the gastrointestinal tract.

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Case Report: Primary melanoma of the gastroesophageal junction

Cited by 4 publications

References 18 publications

Primary Esophageal Melanoma

Primary Esophageal Melanoma

Primary malignant melanoma in gastroesophageal junction with 36 months’ recurrence-free: a case report

A case of primary malignant melanoma of the esophagogastric junction with abscopal effect after nivolumab administration

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