While gastrointestinal (GI) complications are common in pediatric patients following heart transplantation, reports of severe immunemediated bowel disease are mainly limited to case reports. [1][2][3][4][5][6][7][8] Inflammatory bowel disease (IBD) following solid organ transplantation (SOT) is also rarely described in the pediatric literature. 9,10 The etiology of immune-mediated bowel disease is thought to involve activation of the mucosal immune system in response to the intestinal microbiota. Diagnosis in the setting of SOT may be delayed given concerns for post-transplant malignancy or infection, and treatment may be complex given existing immunosuppression. 11 In this case report, we describe a pediatric patient who presented with clinical symptoms consistent with bowel disease believed to be secondary to altered T-cell repertoire 10 years following orthotopic heart transplantation, which was refractory to standard medications but responded to basiliximab therapy.
| C A SEOur patient is a 10-year-old girl diagnosed with pulmonary atresia with an intact ventricular septum at birth who received an orthotopic heart transplant at 2 weeks of life. She had a thymectomy at the time of her heart transplant. She received anti-thymocyte globulin (ATG) for induction (total induction dose 5 mg/kg) and methylprednisolone 10 mg/kg/dose intravenous (IV) for eight doses, followed by a taper. She also received cytomegalovirus (CMV) immune globulin given her