“…The promoters of PPARA-regulated downstream targets in lipid metabolism, such as HADHA, HADHB, MLYCD, and PNPLA2, 32,33,34 showed suppressed acetylation levels in PLN-R14del hearts. Furthermore, by comparing PLN-R14del hearts with non-PLN-R14del-related cardiomyopathies, we identi ed PLN-R14delspeci c regions and many annotated genes in these regions also involved in lipid metabolism (e.g.…”