Case Report on a Child with Paroxysmal Cold Haemoglobinuria

Gunawardena, Dammika; Velu, M; Senaviratne, Sumudu Nimale

doi:10.1007/s12288-011-0094-y

Cited by 6 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Severe and rapidly progressive anemia occurs, often (as in the case reported here) with a relative reticulocytopenia. The reticulocytopenia is thought to represent an ineffective bone marrow response either due to marrow suppression from viral infection or other causes [ 5 , 6 , 10 ]. Although acute episodes of hemolysis are frequently severe, PCH typically resolves spontaneously within a few days to weeks after onset.…”

Section: Discussionmentioning

confidence: 99%

Case report: paroxysmal cold hemoglobinuria presenting during pregnancy

2015

View full text Add to dashboard Cite

BackgroundParoxysmal cold hemoglobinuria is caused by a biphasic IgG autoantibody that triggers complement-mediated intravascular hemolysis. Paroxysmal cold hemoglobinuria has not previously been reported to occur in association with pregnancy.Case presentationWe report a case of an 18 year old female who presented in early pregnancy with acute hemolytic anemia and a positive Donath-Landsteiner antibody test. She was diagnosed with paroxysmal cold hemoglobinuria and treated supportively. Her hemolysis resolved within 6 weeks. Because maternal IgG autoantibodies can cross the placenta, the patient was monitored closely throughout her pregnancy for recurrence. The outcome of the pregnancy was successful, with no evidence of neonatal anemia or hemolysis.ConclusionThis patient had a classic presentation of paroxysmal cold hemoglobinuria with rapid onset of hemolytic anemia that resolved spontaneously. To our knowledge, this is the first report of paroxysmal cold hemoglobinuria presenting during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Case report: paroxysmal cold hemoglobinuria presenting during pregnancy

2015

View full text Add to dashboard Cite

show abstract

“…[ 6 ] The disease has preponderance for male gender and affects young children more than the elderly. [ 7 8 9 ] The disease usually presents 2–3 weeks' postinfection (viral or bacterial) with upper respiratory tract and gastrointestinal symptoms along with PCH. [ 6 10 11 ] In the present case, the patient was an elderly male with a recent history of viral infection followed by the onset of signs and symptoms of hemolysis.…”

Section: Discussionmentioning

confidence: 99%

Applying Donath–Landsteiner test for the diagnosis of paroxysmal cold hemoglobinuria

Tiwari

Aggarwal

Mitra

et al. 2020

Asian J Transfus Sci

View full text Add to dashboard Cite

61-year old male patient was admitted to the hospital with clinical picture of hemolytic anemia with hemoglobinuria. Patient was suspected to have Infectious Mononucleosis (IM) with Auto Immune Hemolytic Anemia (AIHA). DAT was positive with anti-C3d specificity. Donath Landsteiner (DL) test was positive; confirming Paroxysmal Cold Hemoglobinuria (PCH). The final diagnosis was IM with PCH. Patient was managed conservatively and discharged after seven days. DL test specifically detects a biphasic autoantibody (IgG type) that binds to RBCs at cold temperatures, and fixes complement on the RBC membrane. However RBCs are only lysed upon warming to 37C when complement cascade proceeds to completion.

show abstract

“…Acute PCH predominantly occurs in the pediatric population with a recent history of viral illnesses or following immunization [ 9 ]. The incidence in pediatric groups is 0.001/100000 per year in boys and 0.0005/100000 per year in girls [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Parvovirus B19 Infection Induced Paroxysmal Cold Hemoglobinuria in an Adult Female

Kuruvilla

Vinay

Rajendran

et al. 2020

Cureus

View full text Add to dashboard Cite

Paroxysmal cold hemoglobinuria (PCH) is a rare form of autoimmune hemolytic anemia (AIHA). PCH occurs in acute and chronic forms. The main risk factors for PCH include viral infections, vaccination, and syphilis. PCH presentations are common in the pediatric population. The occurrence of PCH following parvovirus B19 infection in adults is rare. We report a case of a 23-year-old female who presented with giddiness, fatigue, greying of vision, and presyncope for four days, on subsequent evaluation was found to have evidence of hemolysis and bone marrow suppression. Parvoviral intranuclear inclusions were detected in bone marrow biopsy and parvoviral B19 IgM antibody was detected. Donath Landsteiner antibody test was also positive. Hence a diagnosis of PCH secondary to parvovirus B19 infection was made. She was started on pulse dose steroids and intravenous immunoglobulin (IVIG) and showed significant improvement.

show abstract

Case Report on a Child with Paroxysmal Cold Haemoglobinuria

Cited by 6 publications

References 5 publications

Case report: paroxysmal cold hemoglobinuria presenting during pregnancy

Case report: paroxysmal cold hemoglobinuria presenting during pregnancy

Applying Donath–Landsteiner test for the diagnosis of paroxysmal cold hemoglobinuria

A Rare Case of Parvovirus B19 Infection Induced Paroxysmal Cold Hemoglobinuria in an Adult Female

Contact Info

Product

Resources

About