Case report of squamous cell cancer arising in perineal epidermal inclusion cyst, presenting as rapidly enlarging and cavitating lesion

Abstract

HighlightsPerineal inclusion cysts may harbor clinically occult malignant degeneration.Histological analysis of large inclusion cysts required to rule out occult malignancy.Perineal cysts with malignant degeneration are diagnostic, reconstructive challenge.Risk of malignancy in perineal inclusion cysts helps treatment decisions.Large perineal cyst requires multidisciplinary surgical team for excision and closure.Colostomy as adjunct of perineal reconstruction after excision of inclusion cyst.Perineal inclusion cysts may present as atypical, cavitating lesions.

Epidermal Inclusion Cyst of the Perianal Region: Report of a Rare Case

“…The differential diagnosis of epidermal cyst involving perineal region includes pilonidal cyst, abscess, dermoid cyst, lipoma, or benign teratoma [5]. Although these are clinically asymptomatic, few cases have been reported where they underwent malignant transformation [6]. Squamous cell carcinomas arising from the epidermal cysts are considered to be even rarer [7].…”