Case report of SOD1 ALS presenting with prominent hearing impairment

Anshu, Piyush; Jadhav, Dnyaneshwar; Agrawal, Shruti; Durge, Vruj; Jain, Neeraj; Ravat, Sangeeta

doi:10.1016/j.jns.2021.118345

Cited by 1 publication

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“…The endogenous antioxidant systems within involve enzymes such as vitamins A, E, and C, flavonoids such as quercetin, and trace As the perception of sound is a highly neurocognitive process involving numerous brain networks directly or indirectly involved in auditory processing and representation [18,292,293], the loss of primary auditory inputs results in a major restructuring of the neurological network beyond the auditory cortices [294,295]. In addition, recent studies revealed the co-occurrence of altered auditory perception in neurodegenerative conditions [296][297][298][299], with age-related etiologies. Hence, it does not come as a surprise that there are significant associations between hearing impairment and the development of dementia and alternate neurological conditions [300], particularly neuropsychiatric conditions involving multisensory perception [301,302].…”

Section: Targeting Redox Imbalance-driven Hearing Impairment With Ant...mentioning

confidence: 99%

A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment

Yeo,

Kwon,

Rinai

et al. 2024

Antioxidants

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The etiology of hearing impairment is multifactorial, with contributions from both genetic and environmental factors. Although genetic studies have yielded valuable insights into the development and function of the auditory system, the contribution of gene products and their interaction with alternate environmental factors for the maintenance and development of auditory function requires further elaboration. In this review, we provide an overview of the current knowledge on the role of redox dysregulation as the converging factor between genetic and environmental factor-dependent development of hearing loss, with a focus on understanding the interaction of oxidative stress with the physical components of the peripheral auditory system in auditory disfunction. The potential involvement of molecular factors linked to auditory function in driving redox imbalance is an important promoter of the development of hearing loss over time.

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