Case report of primary serous adenocarcinoma of fallopian tube - a diagnostic dilemma

Gayam, Susheela; Babu, C Aligar; V.V.S, Lakshmi; Maddali, Srinivas

doi:10.17511/joog.2018.i04.01

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…Such clinical picture is reported in 15 to 20% of cases; in the remaining cases, FTC disguises as hydro-or hematosalpinx, cysts or ovarian cancer, endometrial cancer, uterine leiomyoma, inflammatory process, acute abdomen, and other diseases that greatly complicate FTC diagnosis [1, 3,19]. To date, even in specialized oncology hospitals, reliable preoperative diagnoses range from 0 to 10-15% [21,22,23], and errors during laparotomies and laparoscopies reach 50% [24,25].…”

Section: Causes Of Ftcmentioning

confidence: 99%

“…In the following years, this technique, especially bicontrast methods of examination, made it possible to recognize FTC before surgery in ≥50% of cases [1,3]. Nowadays, sonography and magnetic resonance imaging (MRI) are successfully replacing radiocontrast diagnostic methods in gynecologic oncology [25,27,28]. Transvaginal 3D and Doppler ultrasonography allow to detect not only the anatomical changes characteristic of FTC (sausageshaped mass, thickening of the walls, papillary projections, infiltrates), but also the changes in the vascular geometry characteristic of cancer.…”

Section: Problems and Capabilities Of Ftc Diagnosismentioning

confidence: 99%

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Primary Fallopian Tube Cancer: A Literature Review

Sumtsov

2023

EUMJ

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This literature review presents an analysis of diagnostic methods and treatment of a relatively rare and highly malignant tumor – primary fallopian tube cancer, which is poorly studied and difficult to diagnose. The study of the fallopian tube disorder is very relevant, as the fallopian tube mucosa can be a source of "serous carcinogenesis" for serous ovarian and peritoneal cancer. The author selected more than 50 scientific works from the world literature on the problems of incidence, diagnosis, and treatment of primary fallopian tube cancer and conducted a detailed analysis of them. The author draws attention to the risk group for primary fallopian tube cancer. Women with BRCA-1 and BRCA-2 mutations are more likely to develop FTC, especially in families with a history of breast and (or) ovarian cancer. Approximately 30% of women with FTC have a BRCA-1 or BRCA‑2 mutation. All patients with a burdened history and pathologic mutations should be considered candidates for routine rehabilitation. The author analyzes options for improving preoperative diagnosis using modern methods of additional examination, such as tumor markers, vacuum suction biopsy, transvaginal ultrasound, CT and MRI, and diagnostic laparoscopy. The author emphasizes that it is possible to avoid diagnostic errors during operations using a detailed examination of the affected fallopian tube mucosa on a longitudinal section and suboperative methods of morphological diagnosis. In addition, the author points out the prognostic importance of adequate staging and complete courses of adjuvant polychemotherapy according to modern clinical protocols. The author also draws attention to the interdependence of prevention methods, diagnosis, and treatment of FTC and ovarian cancer.

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Section: Causes Of Ftcmentioning

confidence: 99%

Section: Problems and Capabilities Of Ftc Diagnosismentioning

confidence: 99%

Primary Fallopian Tube Cancer: A Literature Review

Sumtsov

2023

EUMJ

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“…Діагностувати це захворювання не завжди просто навіть під час лапаротомії та лапароскопії. Це підтверджується повідомленнями про 30-50% помилкових діагнозів і під час операцій, оскільки РМТ часто маскується під невинні гідро-гематосальпінкси або інші захворювання [1,[8][9][10].…”

Section: вступunclassified

“…В доступній літературі ми не зустріли робіт узагальнюючого характеру стосовно проблем діагностики РМТ під час операцій. Переважають описи окремих спостережень РМТ, часто без аналізу складності та причин помилок діагностики [8,9,11]. Під час операцій, крім візуального огляду, практично в усіх хворих проводиться ревізія органів черевної порожнини і регіонарних груп лімфатичних вузлів (ЛВ) шляхом пальпації.…”

Section: вступunclassified

Problems of primary fallopian tube cancer diagnostics during and after surgery

Сумцов¹,

Гладчук

Sumtsov

et al. 2021

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To date, the reliable diagnoses primary fallopian tube cancer (PFTC) before surgery range from 0% to 10–15%. Number of misdiagnosis even during operations reaches 30–50% and PFTC is often disguised as innocent hydro-hematosalpinx or other diseases.Research objective: to study the possibilities of PFTC diagnosis during laparotomy and laparoscopy, macroscopic examination of removed macrodrugs, suboperative use of morphological studies, problems of histological interpretation of PFTC after surgery.Materials and methods. During the period from 1966 to 2020 authors of article selected and retrospectively studied quite informative medical histories of 105 patients with PFTC aged 34 to 78 years (mean age 55.8 years). All patients were operated. Revision of the pelvic organs and abdominal cavity was performed during operations. Removed macrodrugs were examined macroscopically and histologically. According to the indications during operations histological and cytological methods of rapid diagnosis were used. Immunohistochemical methods were used to interpret rare and difficult to diagnose tumors after surgery.Results. Only 7 (6.6%) from 105 patients with PFTC was not recognized during surgery, and 18 (17.1%) were diagnosed only after suboperative histological examination. Errors during operations in the initial PFTC forms (without careful study of macrodrugs and suboperative morphological examination) can reach 23.8%. Problems with the primary lession interpretation, which arose in 11 (10.5%) patients with a pronounced tumor process, did not prevent the choice of adequate surgery. The tumor dissemination of the fallopian tube outside was detected in 69 (72.4%) patients, in 25 (26.2%) among them there were lymph node metastases.Conclusion. Careful revision of the abdominal organs and macroscopic examination of removed drugs using suboperative morphological studies avoids errors in the diagnosis and surgical treatment of patients with PFTC.

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Magnetic Resonance and Computer Tomography in the Diagnosis of Primary Fallopian Tube Cancer

Sumtsov,

Skulbeda,

Sumtsov

et al. 2024

EUMJ

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Primary fallopian tube cancer (PTC) is a rare, highly malignant and difficult to diagnose disease. It accounts for 1.3–1.8% of all cases of cancer of the female genital organs and at least 4–6% of cancer of the uterine appendages. Epidemiological studies indicate an increase in the incidence of PTС. For example, according to American authors, from 2001 to 2014, it increased 4 times. Clinical manifestations of PTС are nonspecific and in the early stages of development, the tumor is disguised as other diseases, such as hydro-hematosalpinx, chronic inflammatory diseases, ovarian-menstrual cycle disorders, uterine leiomyoma, and others. Even in specialized oncology hospitals, reliable preoperative diagnoses range from 0 to 10-13%, and in the general medical network, even during operations, false diagnoses reach 50%. Without additional methods of examination, it is almost impossible to make a reliable diagnosis of PTС before surgery. Previously, for the purpose of diagnosing primary fallopian tube cancer, X-ray methods were used, then sonography, and nowadays magnetic resonance tomography (MRT) and computer tomography (CT) have started to be used in parallel with sonography. The aim of the study: to demonstrate cases of examination and diagnosis of primary fallopian tube cancer before surgery by MRT and to review the literature on the specified problem. Materials and methods: the study was conducted on the basis of the Sumy Regional Clinical Oncology Dispensary during 2015-2022. Four patients were examined by the magnetic resonance method and 15 women by the computer tomography method; an analysis of 26 scientific sources of the world's periodical literature on the problems of MRІ diagnosis of PTC was carried out; statistical processing of the material. Results and discussion: In almost two patients with primary fallopian tube cancer examined by MRT, correct diagnoses were made before surgery, and out of 15 examined by the CT method, only two cases revealed a suspicion of PTC. Conclusions. In the diagnosis of primary fallopian tube cancer, MRT has significantly greater capabilities than sonography and computer tomography.

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Case report of primary serous adenocarcinoma of fallopian tube - a diagnostic dilemma

Cited by 4 publications

References 11 publications

Primary Fallopian Tube Cancer: A Literature Review

Primary Fallopian Tube Cancer: A Literature Review

Problems of primary fallopian tube cancer diagnostics during and after surgery

Magnetic Resonance and Computer Tomography in the Diagnosis of Primary Fallopian Tube Cancer

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