Case report of granular cell tumor of the vulva and review of current literature

Hong, SC; Lim, Yong Kuei; Chew, Sung Hock; Chia, Yin Nin; Yam, Kwai Lam

doi:10.1016/j.gynor.2012.10.008

Cited by 21 publications

(35 citation statements)

References 7 publications

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“…Immunohistochemistry helps as GCTs stain negative for desmin, cytokeratins, epithelial membrane antigen and glial fibrillary acidic protein. 4 GCTs on the extremities, including palm, thigh, and digits, are even rarer, and a GCT involving fingernail matrix, as seen in our case 3, has never been reported in English literature.…”

Section: Discussionmentioning

confidence: 59%

“…GCTs are composed of loosely infiltrating sheets of characteristic large pale polyhedral cells with abundant fine or coarsely granular eosinophilic cytoplasm and a centrally situated pale nucleus. 4 Immunohistochemically, GCTs stain positive for S100 protein, and neuron specific enolase, and the granules typically stain with PAS. 5 Although most GCTs are considered benign, 1-7% of malignant cases and association with regional or distant metastasis, and multiple organ involvement have been reported.…”

Section: Discussionmentioning

confidence: 99%

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Granular Cell Tumors on Unusual Anatomic Locations

Kim

Lee

2015

Yonsei Med J

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Granular cell tumors (GCTs) are soft tissue tumors, which are thought to be derived from Schwann cells. Although most GCTs are reported to arise in tongue and oral cavity (30-50%), they can appear on any anatomic sites, even visceral organs. Herein, we report 5 cases of GCTs on unusual anatomic locations, such as palm, arm, thigh, finger, and vulvar area. Complete surgical excision is preferred treatment of choice to prevent recurrence. These cases emphasize that GCTs not involving oral cavity are more prevalent than expected, and the diagnosis should be histopathologically confirmed.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Granular Cell Tumors on Unusual Anatomic Locations

Kim

Lee

2015

Yonsei Med J

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“…Las células se distribuyen en láminas y nidos de tamaño variable, que parecen infiltrar los haces de colágeno y músculo 2,3,5,6,7 Los hallazgos microscópicos suelen ser suficientes pero la inmunohistoquímica es útil para confirmar el diagnóstico: presenta positividad para la proteína S-100 ( fig.3). También se ha descrito positividad para CD68, CD57 (Leu-7), enolasa neuronal específica, laminina, lecitina, HLA-DR, proteína básica de la mielina, y el antígeno carcinoembrionario (CEA), aunque hay casos CEA negativos 5,7 .…”

Section: Discussionunclassified

“…Durante el seguimiento, debe realizarse una exploración completa, ya que podemos encontrar metástasis a distancia después de una primera lesión vulvar 8 . No responden a radiación o quimioterapia y el tratamiento es quirúrgico con escisión local amplia con linfadenectomía 7 .…”

Section: Discussionunclassified

Tumor de células granulares de la vulva: caso clínico

Campo

Herrera

Ros

et al. 2017

Rev. chil. obstet. ginecol.

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RESUMENEl tumor de células granulares es una neoplasia de la piel y los tejidos blandos muy poco frecuente, benigna y de crecimiento lento, pero con altas tasa de recurrencia. La localización más frecuente en el aparato genital es en la vulva. Se debe realizar diagnóstico diferencial con otras lesiones vulvares, debido al manejo distinto de esta tumoración. El diagnóstico generalmente es histológico, ya que clínicamente es muy difícil diferenciarlo de otras tumoraciones a nivel vulvar. El tratamiento recomendado es la exéresis quirúrgica, con márgenes de seguridad. En caso de bordes afectos, se recomienda realizar una reescisión, por la frecuencia de recurrencia local y porque ésta puede ser el primer indicador de una conducta agresiva. Presentamos un caso clínico a nivel vulvar, con el objetivo de destacar la importancia de realizar un diagnóstico correcto, para un buen manejo clínico y seguimiento. Las formas malignas suponen menos del 3% de estos tumores y son muy agresivas PALABRAS CLAVE: tumor células granulosa, tumor vulva, lesión benigna vulvar ABSTRACTThe granular cell tumor is a neoplasm of the skin and soft tissue very rare, benign and slow growing, but with high recurrence rate. The most frequent location in the genital tract is in the vulva. Differential diagnosis should be made with other vulvar lesions, due to differences in the management of this tumor. The diagnosis is usually histological, since it is clinically difficult to differentiate it from other tumors at the vulvar level. The recommended treatment is surgical excision, with safety margins. In case of affected borders, it is recommended to perform a resection, due to the local recurrence and this may be the first indicator of aggressive behavior. We present a clinical case at the vulvar level, in order to emphasize the importance of making a correct diagnosis, for a good clinical management and follow-up. Malignant forms account for less than 3% of these tumors and are very aggressive.

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“…GCT is a rare tumor, occuring in a wide variety of visceral and cutaneous sites throughout the body [4]. The most common location of GCT in the female genital tract is on the labia followed by perineal area and vaginal introitus.…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Tumor of the Vulva with a Local Recurrence after Nine Months: A Case Report

MadÅ3⁄4arac¹,

ValetiÄ²,

Kulaš³

et al. 2015

J Clin Case Rep

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Granular Cell Tumor (GCT) is a rare female genital tract tumor. Most of the tumors are benign, however malignant variants have been reported in cases of multicentric or metastatic diseases. We present a case of an infiltrative variety of benign granular cell tumor that was totally excised under general anesthesia. Wider local excision was made following recurrence of the tumor after nine months. There was no evidence of the disease during four years of follow up.

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Case report of granular cell tumor of the vulva and review of current literature

Abstract: ► We present four cases of benign granular cell tumours of the vulva managed between 1998 and 2001. ► We discuss the clinical and histopathological features of this condition. ► Treatment of this condition is primarily surgical.

Cited by 21 publications

References 7 publications

Granular Cell Tumors on Unusual Anatomic Locations

Granular Cell Tumors on Unusual Anatomic Locations

Tumor de células granulares de la vulva: caso clínico

Granular Cell Tumor of the Vulva with a Local Recurrence after Nine Months: A Case Report

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