Case report of granular acute lymphoblastic leukemia and review of the literature

Jia, Sangyang; Jae, James; Hsia, Cyrus C.

doi:10.1002/ccr3.1866

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Granular ALL is defined by more than 5% marrow blasts having at least three azurophilic cytoplasmic granules. The Pediatric Oncology Group study also found that granular ALL was more frequent amongst FAB L2 compared to FAB L1 and that those with granular lymphoblasts had a significantly lower complete remission rate and event free survival [6] .…”

Section: Discussionmentioning

confidence: 94%

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B lymphoblastic leukemia with granules mimicking acute myeloid leukemia in a 4 years female child

Amrutwar¹,

Swami²

2020

Int. J. Clin. Diagn. Pathol.

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Granular acute lymphoblastic leukemia [ALL] is a rare morphological variant of ALL characterized by cytoplasmic azurophilic granules or inclusions positive for aspecific esterase and acid phosphatase with heterogeneous features at the ultrastructural level. Granular ALL usually occur in children [2-7%] but is extremely rare in adults. It is important to perform cytochemical staining and flow cytometry to make the distinction between acute myeloid and lymphoblastic leukemia. We review the case history and pathological findings in a 4 years female child with initial cytomorphological diagnosis of AML which after flow cytometry turned out to be granular ALL.

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Section: Discussionmentioning

confidence: 94%

“…Diagnostic confusion may arise in ALL with cytoplasmic granular inclusions resembling that of AML. It is important to confirm the type of acute leukemia with flow cytometric immunophenotyping in all cases [6] .…”

Section: Discussionmentioning

confidence: 99%