“…In traditional medicine, this prescription has been used to treat numbness or cold hypersensitivity in the extremities, fatigue, and pain. Studies have found that treatment with this formula could ameliorate CIPN in preclinical [ 71 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 118 ] and clinical settings [ 113 , 114 , 115 , 196 , 197 , 198 ], with controversial prevention effects [ 116 , 117 , 196 , 197 , 199 ].…”