Case Report: MIS-C Temporarily Associated With COVID-19 Complicated by Reye's Syndrome

Abstract

We describe a 7-year-old child with multisystemic inflammatory syndrome that was temporarily associated with the novel coronavirus disease which evolved into serious illness, with coronary aneurysm, using human immunoglobulin and acetylsalicylic acid, in which clinical manifestations including hepatitis, convulsions, and coma were aggravated with Reye's syndrome. To date, there has been no report of the association of multisystemic inflammatory syndrome that is temporarily associated with the novel coronavirus disease and Reye's syndrome.

COVID-19–Associated Thrombotic Response Syndrome in Children: Case Report

“…Experimental mice infected with a non-neurotropic influenza show memory deficits associated with elevated hippocampal cytokines production by activated microglia despite lack of viral genome in the hippocampus. 4 Similar mechanisms may be involved in the hippocampal damage of our patient.…”

“…MIS-C is characterized by a generalized inflammatory response, while COVID-19-associated thrombotic response syndrome is characterized by a prothrombotic state that increases the risk of blood clots. 4,5 In terms of clinical presentation, MIS-C is characterized by symptoms such as persistent fever, widespread body inflammation and involvement of multiple organ systems such as the heart, lungs, gastrointestinal tract and central nervous system. 4 On the other hand, COVID-19associated thrombotic response syndrome is described by a prothrombotic state that increases the risk of blood clots, leading to serious complications such as deep vein thrombosis, pulmonary embolism and stroke.…”

Paenibacillus dendritiformis Meningitis, Brain Abscesses and Cystic Encephalomalacia in an Infant: Case Presentation and Review of the Literature

“…2,3 Only a few cases of human infections caused by C. celerecrescens have been reported (Table S2, Supplemental Digital Content 1, http://links.lww.com/INF/E809). [4][5][6] There are some features of our case that deserve discussion. First, cefuroxime was started initially and then changed to meropenem.…”

Multisystem inflammatory syndrome in children

“…However, use aspirin cautiously because of the risk for Reyes syndrome in children. 20 Broad-spectrum antibiotics may be given initially for possible toxic shock syndrome or bacterial sepsis, pending negative cultures. Antivirals are not routinely recommended in the management of MIS-C. 19 CONCLUSION SARS-CoV-2 is a novel virus, so evidence to understand its association with MIS-C in children and adolescents is limited.…”

“…Patients who meet the criteria for Kawasaki disease should receive aspirin in addition to IVIG and corticosteroids. However, use aspirin cautiously because of the risk for Reyes syndrome in children 20…”