Case Report: Microcystic Adnexal Carcinoma Following Radiotherapy in Childhood

Borenstein, Amiram; Seidman, Daniel S.; Trau, Henri; Tsur, Haggai

doi:10.1097/00000441-199104000-00006

Cited by 33 publications

(32 citation statements)

References 16 publications

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“…At clinical examination most often asymptomatic slowly growing nodules or cyst-like tumors are found, some presenting with a scar-like appearance [7,10]. The tumor can be mistaken for other neoplasms, such as squamous cell carcinoma [7,12,13,21] as in the first biopsy of our patient.…”

Section: Discussionmentioning

confidence: 68%

“…Due to their longer life expectancy and their still growing organs children are particularly at risk [8,15,25,27,31,33,36,38,40,42,45,46,57,59]. As one of the most serious late sequelae of radiotherapy, secondary malignancies can develop after a long latent period [4,10,20]. Most literature is about secondary malignant neoplasms in Hodgkin's disease and brain tumors.…”

Section: Introductionmentioning

confidence: 99%

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A Microcystic Adnexal Carcinoma in the Auditory Canal 15 Years after Radiotherapy of a 12-Year-Old Boy with Nasopharynx Carcinoma

et al. 2005

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

A Microcystic Adnexal Carcinoma in the Auditory Canal 15 Years after Radiotherapy of a 12-Year-Old Boy with Nasopharynx Carcinoma

et al. 2005

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“…However, MAC have already been observed in sites not exposed to UV radiation: trunk, vulva [8, 9], axilla and buttocks [10] and the perianal skin [11]. Previous radiotherapy is also considered as a risk factor since MAC have been reported after radiation treatments delivered for tinea capitis in childhood [12], for acne [13,14,15,16], for a periorbital rhabdomyosarcoma [14] or for central nervous system leukemia [17]. In the present study, the patients did not remember to have had any ionizing radiation exposure.…”

Section: Discussionmentioning

confidence: 99%

Microcystic Adnexal Carcinoma: Report of Seven Cases Including One with Lung Metastasis

et al. 2006

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Background: Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm, with a high rate of local recurrences. Objective: A series of MAC was analyzed and compared to previously published cases. Methods: Seven cases of MAC were identified in the register of the institution. Medical and pathological records were reviewed. Results: The primary MAC were located on the face in all patients, and 85% were initially misdiagnosed. The mean follow-up duration was 108 months. The recurrence rate was high: 4 patients developed recurrences. In 3 patients, the course of the disease was severe: one of them developed pathologically proven lung metastasis. Conclusion: The present study and review of the literature confirm the clinically aggressive evolution of MAC and its rare ability to give rise to metastasis. Long-term clinical follow-ups with imaging investigations are mandatory.

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“…1,3,5,18,23,28 In several cases the patients had previously received radiotherapy for adolescent acne or cancers. 1,4,5,[28][29][30][31] At the time of diagnosis the patients' ages range from 18 years to 82 years, but most patients are beyond 60 years. [1][2][3][4]8,16,32 Quite often MAC is an asymptomatic tumor that appears clinically as a plaque or nodule with slow, but infiltrative and destructive, local growth.…”

Section: Discussionmentioning

confidence: 99%

Microcystic Adnexal Carcinoma: An Often Misdiagnosed, Locally Aggressive Growing Skin Tumor

Fischer

Breuninger²,

Metzler³

et al. 2005

Journal of Craniofacial Surgery

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Microcystic adnexal carcinoma (MAC) belongs to the spectrum of locally aggressive adnexal carcinomas and most commonly occurs in the head and neck region. Recently it has been proposed that MAC is an apocrine tumor. It is characterized by slow, but locally aggressive growth with infiltration of subcutaneous fat tissue, muscles, perichondrium, periosteum, or perineurium. As a result, surgical treatment often leads to ablation defects, which are many times the size of the clinical lesion. In 1982, Goldstein and colleagues first reported MAC to be a distinct histologic entity characterized by a combination of keratinous cysts in the upper dermis, islands and strands of small basaloid, benign-appearing keratinocytes or squamous cells in the deeper dermis within a dense desmoplastic stroma, and areas of ductular differentiation. The authors report the case of a 78-year-old woman in whom a diagnosis of MAC was made when a tumor on the right cheek recurred for the second time. Previous histopathologic diagnoses were squamous cell carcinoma and desmoplastic trichoepithelioma. Local recurrences of the tumor occurred, despite histographic surgery because in hematoxylin and eosin stains, small islands of the deceptively benign-appearing small basaloid cells of MAC were not recognized as tumor cells. The reported case demonstrates the difficulties in diagnosing MAC and indicates that MAC should always be considered in the differential diagnosis of slowly growing tumors in the head and neck region. If MAC is diagnosed too late, it can be inoperable because of its infiltrative growth.

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Case Report: Microcystic Adnexal Carcinoma Following Radiotherapy in Childhood

Cited by 33 publications

References 16 publications

A Microcystic Adnexal Carcinoma in the Auditory Canal 15 Years after Radiotherapy of a 12-Year-Old Boy with Nasopharynx Carcinoma

A Microcystic Adnexal Carcinoma in the Auditory Canal 15 Years after Radiotherapy of a 12-Year-Old Boy with Nasopharynx Carcinoma

Microcystic Adnexal Carcinoma: Report of Seven Cases Including One with Lung Metastasis

Microcystic Adnexal Carcinoma: An Often Misdiagnosed, Locally Aggressive Growing Skin Tumor

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