Case report: Malignant teratoma of the uterine corpus

Newsom-Davis, Thomas; Poulter, Daniel; Gray, R Ian; Ameen, Mohammed; Lindsay, Iain; Papanikolaou, Kyriakos; Butler‐Manuel, Simon; Christmas, T. J.; Townsend, P. T.; Seckl, Michael J.

doi:10.1186/1471-2407-9-195

Cited by 25 publications

(32 citation statements)

References 12 publications

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“…However, Newsom-Davis et al 2 . described a para-aortic lymph node recurrence that occurred six months after surgery in a patient that was submitted to clinical follow-up alone.…”

Section: Discussionmentioning

confidence: 99%

Immature Uterine Teratoma Associated with Uterine Inversion

et al. 2014

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Teratomas are the most commonly diagnosed germ cell tumors and occur primarily in testes and ovaries. Platinum-based therapy followed by surgical resection of the residual lesion is generally the recommended treatment. In contrast, immature uterine teratomas are rare, with few cases reported in the literature. Moreover, there is no standard treatment for these tumors. Non-puerperal uterine inversion is also rare in women younger than 45 years of age, and neoplastic lesions are responsible for this condition. Here, we report a case of an immature uterine teratoma associated with uterine inversion. The patient underwent surgery followed by adjuvant chemotherapy and continues to be monitored.

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“…However, Newsom-Davis et al 2 . described a para-aortic lymph node recurrence that occurred six months after surgery in a patient that was submitted to clinical follow-up alone.…”

Section: Discussionmentioning

confidence: 99%

Immature Uterine Teratoma Associated with Uterine Inversion

et al. 2014

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“…Histologically, the majority of the tumors were mature teratomas. To the best of our knowledge, only four cases of immature uterine teratoma have been described so far in the English literature (Table 1) [5–8]. …”

Section: Discussionmentioning

confidence: 99%

“…The first one suggests that uterine teratomas arise from primordial fetal germ cells that had abnormal migration from the fetal yolk sac endoderm to the gonadal ridge during early embryogenesis. As uterus is a midline organ, this supposes that primordial cells had a midline passage [5]. Another hypothesis proposes that residual fetal tissue can be implanted at any site of the genital canal during the fertility process [2, 5].…”

Section: Discussionmentioning

confidence: 99%

Primary Immature Teratoma of the Uterus Relapsing as Malignant Neuroepithelioma: Case Report and Review of the Literature

Mohtaram

Kharmoum

Aaribi

et al. 2013

Case Reports in Oncological Medicine

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Background. Although some mature cases of teratomas have recently been described in the cervix, they are not commonly found in the uterus, especially in immature forms. An immature uterine teratoma relapsing after surgery as malignant neuroepithelioma has never been reported in the literature. Case Presentation. We describe a case of immature teratoma which occurred primarily in the uterus in a 56-year-old female. Treatment consisted of total simple hysterectomy. Three months after surgery, the patient relapsed with voluminous pelvic mass and was treated with bleomycin, etoposide, and cisplatin-containing chemotherapy regimen. Conclusion. In this report and according to the pertinent literature, clinical and pathological features and management of uterine immature teratomas are discussed. The mainstay of treatment is surgery. The prognosis of this unusual disease remains uncertain.

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“…Mature teratomas are made up of differentiated components found in adult such as cartilage or glandular epithelium while immature teratomas contain tissue with incomplete somatic differentiation similar to the fetal tissues. (2) Literature data report mature teratoma association with different types of ovarian malignancy in cases where injuries were identified strictly on the ovaries. (3) The incidence of malignant transformation in mature teratoma of the ovary is less than 2% as reported in gynaecological and pathological literature.…”

Section: Discussion Discussionmentioning

confidence: 99%

Mature Teratoma Associated with Bilateral Ovarian Carcinosarcoma - Accidental Association or Etiopathogenetic Determinism? - Case Report

Bîrlă¹,

Catanescu²,

Caragui³

et al. 2016

chr

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RezumatTeratom matur ovarian bilateral asociat cu carcinosarcom -asociere întâmplãtoare sau determinism etiopatogenic? -prezentare de caz Carcinosarcomul este o forma rarã de cancer ovarian cu origine mixtã, iar asocierea sa cu teratomul matur este extrem de rarã. Prezentãm cazul pacientei T.M. în vârstã de 67 ani, internatã în clinicã în 15.05.2016, F.O. 4877 pentru creaeterea în volum a abdomenului. La internare, pacienta afebrilã, conaetientã, cooperantã, echilibratã cardio-respirator, cu abdomen destins de volum, matitate accentuatã pe flancuri, semnul valului pozitiv, bioumoral în limite normale cu excepåia: acid uric seric = 6.64 mg/dl, glicemie sericã = 113.7 mg/dl, proteine serice totale = 8.65 g/dl, raportul albuminã/globulinã subunitar, CRP 33.63 mg/l, sideremie 51 ug/dl, CA 125 = 588.4 UI. Ecografia abdominalã: cantitate mare de lichid decliv aei perihepatic aei multiple formaåiuni tumorale cu transformare chisticã la nivelul abdomenului aei pelvisului. Examen CT descrie multiple mase tisulare localizate intraperitoneal abdomino-pelvin, manaeonate în epanaeament lichidian, infiltrative, cu efect de masã pe lumenele digestive, fãrã obstrucåie vizibilã CT. Tratamentul chirurgical a constat în evacuarea lichidului de ascitã, excizia formaåiunilor tumorale din marele epiploon, a formaåiunilor tumorale din ligamentul gastro-colic, epiploonectomie, anexectomie bilateralã aei histerectomie totalã. Evoluåie postoperatorie simplã. Examenul histopatologic confirmã diagnosticul de carcinosarcom ovarian bilateral asociat cu teratom matur tridermic (prezenåa zonelor de åesut cerebral, asociat cu åesut cartilaginos, epiteliu de tip tranziåional, epiteliu de tip tubar, stromã de tip endometrial, åesut adipos). IHC confirmã compatibilitatea cu diagnosticul de carcinosarcom ovarian (tumorã malignã mixtã mullerianã). Pacienta a urmat polichimioterapie adjuvantã. Asocierea teratomului cu elemente carcinosarcomatoase conferã cazului un prognostic infaust. Cuvinte cheie: teratom matur, carcinosarcom ovarianAbstract Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113.7 mg / dl, serum total proteins = 8.65 g / dl, the albumin / globulin subunit, CRP 33.63 mg / l, sideremia 51 ug / dl, CA 125 = 588.4 IU. Abdominal ultrasound: high volume fluid and multiple perihepatic formations and multiple formations with cystic Chirurgia (2016) 111: 422-427 No. 5, September -October Copyright© Celsius

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Case report: Malignant teratoma of the uterine corpus

Cited by 25 publications

References 12 publications

Immature Uterine Teratoma Associated with Uterine Inversion

Immature Uterine Teratoma Associated with Uterine Inversion

Primary Immature Teratoma of the Uterus Relapsing as Malignant Neuroepithelioma: Case Report and Review of the Literature

Mature Teratoma Associated with Bilateral Ovarian Carcinosarcoma - Accidental Association or Etiopathogenetic Determinism? - Case Report

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