Case Report: Low-Dose Apatinib in the Treatment of Intrahepatic Biliary Cystadenoma With Recurrence and Malignant Transformation

Yang, Yong‐Guang; Mai, Weiheng; Chen, Weifeng; Yang, Chao; Li, Mingyi; Liu, Lijuan

doi:10.3389/fonc.2021.676092

Cited by 3 publications

(2 citation statements)

References 26 publications

(33 reference statements)

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“…Owing to the recurrence of IBC, it is recommended that patients undergo examination regularly after the operation. Patients with recurrence can be operated actively, and advanced cases with recurrence and malignant transformation should be treated with radiotherapy, chemotherapy, TKI drugs, or hyperthermic perfusion, which is bene cial in alleviating terminal symptoms [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis And Management of Intrahepatic Biliary Cystadenoma: A Single-Center Experiences And Lessons Learned

Yang¹,

Chen²,

Li³

et al. 2021

Preprint

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Background: Intrahepatic biliary cystadenoma (IBC) is a rare benign cystic tumor of the liver with carcinogenic potential. Due to its low incidence and lack of specific clinical symptoms and signs, IBC is easily confused with other cystic liver lesions; even today, IBC mistakenly underwent fenestration and drainage according to the hepatic cyst in adverse conditions consequences for patients.Methods: The clinical data of six patients with pathologically defined IBC, admitted to the Department of Hepatobiliary Surgery of the Affiliated Hospital of Guangdong Medical University from January, 2011, to July, 2021 were retrospectively analyzed.Results: Four patients (4/6) were diagnosed with IBC preoperatively, administrated the surgery, and discharged successfully. One patient underwent single-port laparoscopic fenestration and drainage of liver cyst, cyst wall biopsy, intraoperative pathology revealed IBC, then open left hemihepatectomy. Another patient underwent laparoscopic fenestration and drainage of hepatic cyst. Intraoperative pathologic diagnosis from cyst wall biopsy showed a simple hepatic cyst, but the final pathological diagnosis was IBC. The remaining liver volume was insufficient to undergo liver resection; the patient was again referred to our institution after four months with right upper quadrant pain. Computed tomography revealed extensive abdominal nodules, considered malignant transformation, and the patient died three months later.Conclusion: Since atypical IBC is easily misdiagnosed as hepatic cysts, and we propose paying attention to cystic wall morphology and cyst fluid properties during the operation. At the same time, it is recommended that patients diagnosed with liver cysts undergo intraoperative pathological diagnosis and strengthen communication with pathologists to deepen understanding of IBC, which avoids missed diagnosis, wrong operation, or even secondary operation.

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Section: Discussionmentioning

confidence: 99%

Diagnosis And Management of Intrahepatic Biliary Cystadenoma: A Single-Center Experiences And Lessons Learned

Yang¹,

Chen²,

Li³

et al. 2021

Preprint

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show abstract

“…In addition, the high malignant transformation rate of MCN-L should be taken into account [62,64]. For patients with an inoperable or advanced tumor stage, radiotherapy and chemotherapy can be considered [65].…”

Section: Invasive Mucinous Cystic Neoplasm Of the Livermentioning

confidence: 99%

Comments on and illustrations of the WFUMB CEUS liver guidelines: Rare malignant neuroendocrine and predominant epithelioid liver lesions

Zadeh,

Huber,

Görg

et al. 2024

Med Ultrason

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The diagnosis or rare, non-hematologic malignant lesions of the liver may be a challenge owing to the rarity of the disease, and is usually made by histological confirmation. Ultrasound with color Doppler and contrast-enhanced, if required, taking into account the clinical background of the patient, may help to focus the differential diagnosis. In this review, we describe the pathological and ultrasound features of rare malignant neuroendocrine and predominantly epithelioid liver lesions including primary neuroendocrine tumor of the liver, Invasive mucinous cystic neoplasm of the liver, and also hepatoblastoma.

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Intrahepatic biliary cystadenoma: Confusion, experience, and lessons learned from our center

et al. 2022

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BackgroundIntrahepatic biliary cystadenoma (IBC) is a rare benign cystic tumor of the liver. So far, it has not been comprehensively understood, which causes incorrect diagnosis, treatment confusion, and even inappropriate treatment. Here, we reviewed clinical data of IBC patients in our center, shared our experiences and lessons learned, and improved the level of diagnosis and treatment.MethodsThe clinical data of 10 patients with pathologically diagnosed IBC, admitted to the Department of Hepatobiliary Surgery of the Affiliated Hospital of Guangdong Medical University from January, 2007, to January, 2022 were retrospectively analyzed.Results10 patients underwent surgery and were discharged successfully. Cyst morphology: multiple cysts: 6 cases (6/10), monocular cyst: four cases(4/10). Six patients (6/10) were diagnosed as IBC preoperatively and received hepatectomy. Four patients with monocular cyst IBC underwent intraoperative frozen section examination, except one case showed IBC; the rest were misdiagnosed as simple liver cyst. In three misdiagnosed patients, one underwent open left hepatectomy seven days after the initial operation. The other patient refused to undergo reoperation and required follow-up observation. The last patient could not tolerate hepatectomy due to insufficient residual liver volume and chose follow-up observationConclusionFor IBC, especially monocular IBC, it is easy to be misdiagnosed as simple hepatic cyst, which brings great confusion to clinical treatment. We propose strengthening communication with pathologists to deepen understanding of IBC. Attention should be paid to the cyst wall’s shape and the cyst fluid’s properties during the operation to avoid the missed diagnosis, misdiagnosis, or even improper operation. For suspicious cases, directly choose hepatectomy to avoid reoperation after thoroughly evaluating the patient’s condition.

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Case Report: Low-Dose Apatinib in the Treatment of Intrahepatic Biliary Cystadenoma With Recurrence and Malignant Transformation

Cited by 3 publications

References 26 publications

Diagnosis And Management of Intrahepatic Biliary Cystadenoma: A Single-Center Experiences And Lessons Learned

Diagnosis And Management of Intrahepatic Biliary Cystadenoma: A Single-Center Experiences And Lessons Learned

Comments on and illustrations of the WFUMB CEUS liver guidelines: Rare malignant neuroendocrine and predominant epithelioid liver lesions

Intrahepatic biliary cystadenoma: Confusion, experience, and lessons learned from our center

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