Case Report: Laparoscopic Adrenalectomy in a Patient with Primary Adrenal Malignant Melanoma

Liatsikos, Evangelos; Papathanassiou, Zafiria G; Voudoukis, Theodoros; Repanti, Maria; Sklavou, Christina; Filos, Kriton S.; Stolzenburg, Jens‐Uwe; Athanasopoulos, Anastasios; Perimenis, Petros; Barbalias, George A.

doi:10.1089/end.2006.20.123

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…Primary adrenal melanoma is extremely rare, currently with 23 cases in a literature review. 1 Typically, patients present with abdominal symptoms such as flank pain 2–5 and weight loss. 3,5–8 In this paper, we present a case of primary adrenal melanoma, which initially presented with weight loss, abdominal bloating, distention, intermittent diarrhea, and flatulence, but no flank pain.…”

Section: Introductionmentioning

confidence: 99%

Primary adrenal melanoma: A case report and review of the literature

Cheng

Osinski

Miyamoto

et al. 2021

Journal of Clinical Urology

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BackgroundPrimary adrenal melanoma is extremely rare, currently with 23 cases in a literature review. 1 Typically, patients present with abdominal symptoms such as flank pain 2-5 and weight loss. 3,[5][6][7][8] In this paper, we present a case of primary adrenal melanoma, which initially presented with weight loss, abdominal bloating, distention, intermittent diarrhea, and flatulence, but no flank pain. Case reviewAn 82-year-old male with a history of robotic-assisted laparoscopic prostatectomy for pT2N0 Gleason score 3+4 prostate cancer presented with abdominal bloating, distention, intermittent diarrhea, flatulence, and weight loss. The patient's father had lung cancer, and his mother had a stroke. Under the working diagnosis of irritable bowel syndrome, the patient failed to improve on a gluten-free diet. Subsequently, computed tomography (CT) virtual colonoscopy discovered a large right upper pole renal mass without masses suggestive of primary colon carcinoma. A followup dedicated CT of the abdomen and pelvis confirmed a large 9.5 cm×7.2 cm×9.2 cm mass emanating from either the upper pole of the right kidney or the right adrenal gland (Figure 1). A nuclear bone scan and chest CT were negative for metastatic disease. A positron emission tomography scan showed a hypermetabolic mass from the right adrenal gland, with additional nonspecific hypermetabolic mediastinal and bilateral hilar lymph nodes (Figure 2). There was no biochemical evidence of a functional adrenal mass. His prostate serum antigen was undetectable. The patient had a Karnowski Performance Scale Index of 80, which signifies normal activity with effort with some signs or symptoms of disease. The patient reported no signs of vision change, and thus an ocular melanoma origin was not suspected. Furthermore, the patient reported no neurological deficits to suspect a leptomeningeal origin.

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Section: Introductionmentioning

confidence: 99%

Primary adrenal melanoma: A case report and review of the literature

Cheng

Osinski

Miyamoto

et al. 2021

Journal of Clinical Urology

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“…In 2004, Granero et al [9] described another case in a 78-year-old man. Two years later, in 2006, two more cases were published: one by Liatsikos et al [10] in a 42-year-old man and another by Bastide et al [11] in a 33-year-old woman. We therefore have gathered 11 well-documented case reports, which, together with our present case, makes a total of 12 (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Primary melanoma of the adrenal gland: a case report and review of the literature

et al. 2011

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BackgroundPrimary melanoma of the adrenal gland is exceptionally rare as demonstrated by the few cases reported in the medical literature, and it has a high fatality rate. We present the case of a patient with two relapses and survival to date.Case reportWe describe the case of a 58-year-old Caucasian woman who consulted her doctor with symptoms of asthenia, anorexia and weight loss. A mass was palpated in her abdomen at the height of the left hypochondrium. A computed tomographic scan revealed a retroperitoneal mass measuring 10 cm × 15 cm originating in the left adrenal gland. A left nephroadrenalectomy and splenectomy were performed. Histopathologically, the retroperitoneal mass corresponded to a melanoma, and no primary melanoma was found in any other location. The patient was treated with interferon-α-2b. Three years after her diagnosis the patient presented with a retroperitoneal relapse of the mass measuring 7.2 cm, which was removed. Five years after the first relapse a new retroperitoneal relapse mass was diagnosed, which was also removed. Since then the patient has been healthy and free from illness.ConclusionHistological and immunohistochemical studies, together with the criteria described by Ainsworth et al. and Carstens et al., allowed us to diagnose primary melanoma of the adrenal gland.

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“…10 Because of its rare occurrence, a consensus has not yet been established with respect to adjuvant therapies such as radiotherapy 1 or chemotherapy with dacarbazine. 11 Adrenal metastases of melanoma provide additional evidence of systemic disease with an overall poor prognosis. For these patients, systemic therapy is usually preferred.…”

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confidence: 99%