Case Report: Kikuchi: The great mimicker

Lo, Kevin Bryan; Papazoglou, Anna; Chua, Lorayne; Candelario, Nellowe

doi:10.12688/f1000research.14758.1

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…It is a non-cancerous disorder but occasionally it leads to misdiagnosis such as tuberculosis, rheumatologic and hematologic malignancies. Morphologic examination of the swollen lymph nodes is right path of correct diagnosis in KFD, however, the recognition by morphology is a challenge to many pathologists [2].…”

Section: Introductionmentioning

confidence: 99%

A Recent Case Reports on Unfamiliar Kikuchi-Fujimoto Disease

Kaur¹,

Wani²,

Yadav³

et al. 2019

Med Clin Rev

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Kikuchi-Fujimoto Disease (KFD) is also known as Histiocytic Necrotizing Lymphadenitis. It is very rare, noncancerous and self-limiting Auto-Immune disease but mostly suspected as cancer, tuberculosis and systemic lupus erythematosus. It has symptoms such as cervical lymphadenopathy (enlargement of lymph nodes), low fever, headache, fatigue, night sweats and muscles pain. It typically affects young females aged between 20-35 years and mostly affects Asian populations. The main identification of KFD is characterized by Fine Needle Aspiration Cytology by taking blood sample from the swollen lymph node. Diagnosis is also possible with Fine Needle Aspiration Biopsy. Treatment for this disease has not been established. Non-steroidal Anti-Inflammatory Drugs or steroids are in use to ease the tenderness of lymph node and fever.

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Section: Introductionmentioning

confidence: 99%

A Recent Case Reports on Unfamiliar Kikuchi-Fujimoto Disease

Kaur¹,

Wani²,

Yadav³

et al. 2019

Med Clin Rev

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“…1,2 Case reports also have described KFD manifesting with ataxia, arthritis, parotitis, or ocular pathologies such as conjunctivitis and uveitis. 1,2,8,9 Hepatosplenomegaly is a relatively rare manifestation of KFD seen in approximately 3% of cases. 10 When present, hepatosplenomegaly may make the diagnosis of KFD especially difficult to distinguish from lymphoproliferative disorders such as lymphoma.…”

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confidence: 99%

Kikuchi-Fujimoto Disease: A Case Report of Fever and Lymphadenopathy in a Young White Man

Kellner¹

2023

Federal Practitioner

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Background: Kikuchi-Fujimoto disease (KFD) is a rare cause of rapidly evolving tender cervical lymphadenopathy. It is often initially misdiagnosed and managed as infectious lymphadenitis. Although most cases of KFD are self-limited and improve with antipyretics and analgesics, some are more refractory and may require corticosteroids or hydroxychloroquine therapy. Case Presentation: A 27-year-old White man presented for evaluation of fevers and painful cervical lymphadenopathy. He was found to have KFD on excisional lymph node biopsy. His symptoms proved challenging to manage with corticosteroids but eventually improved with hydroxychloroquine monotherapy.Conclusions: KFD diagnosis should be considered irrespective of geographic location, ethnicity, or patient sex. Hepatosplenomegaly is a relatively rare manifestation of KFD that can make it especially difficult to distinguish from lymphoproliferative disorder, such as lymphoma. Lymph node biopsy is the preferred diagnostic approach to achieve a timely and definitive diagnosis. Although usually self-limited, KFD has been associated with autoimmune conditions, including systemic lupus erythematosus. Securing the diagnosis of KFD is therefore crucial to ensuring patients are monitored appropriately for the development of associated autoimmune conditions.

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