Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

Sarfraz, Shiza; Rafique, Hamza; Ali, Hassam; Hassan, Syed Zawahir

doi:10.12688/f1000research.19981.1

Cited by 3 publications

(3 citation statements)

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“…It is a self-limiting disorder that occurs sub-acutely and commonly presents with fever with cervical lymphadenopathy [ 6 ]. Lymphoma, tuberculosis, systemic lupus erythematosus, and adult-onset Still’s disease are the main differential diagnoses for Kikuchi disease [ 3 ]. While the unilateral involvement of the posterior cervical lymph nodes is the most typical presentation of the disease, a few other uncommon presentations cause diagnostic difficulty [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report

Kularathna,

Medagama,

Bandara

et al. 2024

J Med Case Reports

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Background Kikuchi Fujimoto disease is a rare self-limiting disorder mainly affecting young Asian females. The typical presentation is unexplained fever with associated cervical lymphadenopathy. It can mimic many sinister diseases such as lymphoma, tuberculosis, and systemic lupus erythematosus. Aseptic meningitis due to Kikuchi disease is extremely rare, and majority were reported from Japan. There have been no published cases of aseptic meningitis due to Kikuchi disease in Sri Lanka. Case presentation A 29 years old Sri Lankan female presented with a prolonged fever for three weeks with an associated headache for five days duration. She developed painful cervical lymphadenopathy during the hospital stay. She has been previously well and had been vaccinated against COVID-19 six weeks before. Her lumbar puncture showed lymphocytic pleocytosis with marginally elevated protein levels and reduced ratio of serum to CSF sugar. Lymph node biopsy was consistent with necrotizing lymphadenitis. She was subsequently diagnosed with Kikuchi disease complicated with aseptic meningitis. She responded to corticosteroids well and had an uneventful recovery. Conclusion Kikuchi disease is a rare self-limiting disorder that can be complicated with aseptic meningitis on infrequent occasions. Other conditions such as tuberculosis, lymphoma, systemic lupus erythematosus, and adult-onset Still’s disease should be considered as differential diagnoses. Knowledge of Kikuchi disease and its complications will prevent unnecessary investigations which delay the early diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

“…It was first described in Japan in 1972 [ 2 ]. The most common clinical presentation is unexplained fever and lymphadenopathy, mainly affecting the cervical lymph node group [ 3 ]. Skin rashes, gastrointestinal symptoms, and splenomegaly are the main extra nodal manifestations.…”

Section: Introductionmentioning

confidence: 99%

Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report

Kularathna,

Medagama,

Bandara

et al. 2024

J Med Case Reports

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“…A fever is usually the first symptom in KFD and can be accompanied by upper respiratory symptoms (30-50%), weight loss, night sweats, nausea, vomiting, sore throat, arthralgia, splenomegaly, rash, and leukopenia (about 50%) [9]. Unilateral tender lymphadenopathy involving the jugular and posterior cervical lymph nodes is the most common clinical feature [7], although supraclavicular lymphadenopathy has also been noted [10]. Axillary lymphadenopathy has been reported, but is a rare manifestation of the disease [11,12] and this was seen in our patient.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease: A Differential for When It is Not Systemic Lupus Erythematosus

Kazmi

Greear

Lavallee

et al. 2022

Case Reports in Rheumatology

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Kikuchi-Fujimoto disease (KFD) is a rare and benign disease process that is characterized by fever and lymphadenopathy that was first described in young Japanese women in the early 1970s. Knowledge of KFD is important as it can often mimic other causes of lymphadenopathy including systemic lupus erythematosus (SLE) or malignancies, and this can lead to invasive diagnostic testing and even treatments that can be avoided. The etiology and exact mechanism by which KFD develops is not fully understood at this time, but is thought to be an immune response of T cells and histiocytes to viral or bacterial infections. We present a 35-year-old African-American woman who was referred to the rheumatology clinic by our colleagues in the breast clinic with new onset right axillary lymphadenopathy and abnormal serologic testing with the suspicion of SLE after a malignancy had been ruled out.

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Kikuchi‐Fujimoto disease following SARS‐CoV‐2 infection: A rare disease with increased incidence during the COVID‐19 pandemic?

Leung,

Chan,

Chan

et al. 2024

Respirology Case Reports

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Kikuchi‐Fujimoto Disease (KFD), also known as Kikuchi disease or Kikuchi histiocytic necrotizing lymphadenitis, is a rare and self‐limiting condition characterized by cervical lymphadenopathy and fever, primarily affecting young Asian adults. The aetiology of KFD remains unknown, although various infectious agents have been suggested as potential triggers. With the emergence of the COVID‐19 pandemic, cases of post‐COVID‐19 KFD and post‐COVID‐19 vaccine KFD have been reported. In this article, we present the first case of post‐COVID‐19 KFD in Hong Kong. A 24‐year‐old man developed fever and painful neck swelling 1 month after recovering from COVID‐19. Diagnostic evaluation, including ultrasound‐guided fine needle aspiration cytology (FNAC), confirmed the diagnosis of KFD. The patient's symptoms resolved spontaneously with supportive care. This case underscores the importance of considering KFD as a potential differential diagnosis in patients presenting with cervical lymphadenopathy and fever following COVID‐19 recovery or vaccination.

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Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

Cited by 3 publications

References 8 publications

Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report

Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report

Kikuchi-Fujimoto Disease: A Differential for When It is Not Systemic Lupus Erythematosus

Kikuchi‐Fujimoto disease following SARS‐CoV‐2 infection: A rare disease with increased incidence during the COVID‐19 pandemic?

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