Case Report - Infection of Total Knee Arthroplasty Treated with One-Stage Surgery and Linezolid

Dell’Aquila, Adriana; Janovsky, César; Cohen, Moises

doi:10.7150/jbji.19574

Cited by 1 publication

(1 citation statement)

References 20 publications

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“…The case of a patient with chronic infection of an orthopedic implant treated with linezolid has been reported [10]. In the current study, two cases of acute infection of knee osteoarthritis were successfully treated using linezolid.…”

Section: Introductionmentioning

confidence: 74%

Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus

Negishi

Mitsumatsu

Matsumura

et al. 2022

J Pharm Health Care Sci

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Background Linezolid is a new oxazolidinone antibiotic used for infections caused by methicillin-resistant Staphylococcus and other species. Case presentation Two cases of knee osteoarthritis with acute infection were successfully treated using linezolid. The plasma and synovial fluid concentrations of linezolid in two patients [women aged 69 and 73 years (cases 1 and 2)] with knee osteoarthritis infected with Staphylococcus aureus were measured after they were administered 600 mg twice daily by intravenous infusion. The plasma linezolid concentrations during knee surgery in case 1 at day 5 and in case 2 at day 2 were 19.6 and 15.6 μg/mL, respectively. The synovial fluid concentrations of linezolid in samples taken during surgery in case 1 and case 2 were 14.9 and 17.0 μg/mL, respectively; these values corresponded to ratios of synovial fluid/plasma of 76 and 109%. Possible metabolite 2-hydroxylated linezolid potentially mediated by cytochrome P450 2 J2 was not detected in the plasma or synovial fluid samples under the current clinical setting after multiple doses. Conclusions These results implied nearly equivalent concentrations of linezolid in plasma and synovial fluid of clinical patients with knee osteoarthritis acutely infected with Staphylococcus aureus.

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Section: Introductionmentioning

confidence: 74%