Case Report: Imported Case of Lassa Fever — New Jersey, May 2015

Kulkarni, Prathit A.; Chew, Debra; Youssef-Bessler, Manal; Hamdi, Hanaa A; Montoya, Lindsay; Cervantes, Kimberly B; Mazur, Nicole; Lucas, Diana; Wells, Julia W; Cennimo, David; Sutherland, Anne; Domenico, Linda M Di; Miller, Lincoln P.; Pierre-Louis, Frantz; Rokosz, Gregory; Nazir, Atif; Perio, Marie A. de; Lowe, Luis; Manning, Craig; Mead, Kenneth R.; Christensen, Bryan; Albariño, César G.; Ströher, Ute; Glover, Maleeka; Lifshitz, Edward; Tan, Christina; Rollin, Pierre E.; Semple, Shereen

doi:10.4269/ajtmh.17-0316

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…Oral and nasal oozing of blood was observed in one of the imported cases of Lassa fever [24]. Bleeding was also observed among Lassa fever patients treated in the Lassa fever endemic region.…”

Section: Findings Of Clinical Features Of Lassa Fever Cases Inmentioning

confidence: 93%

“…the non-endemic countries where those 22 cases were seen, what raised the clinical suspicion for Lassa fever were history of recent travel to (or residence in) Lassa fever endemic region, non-responsiveness of the patients to antimalarials or/and antibiotics and negative tests for other known causes of febrile illness. International Journal of Clinical MedicineCase number 9 and case number 20 initially denied visiting the rural area where Lassa fever was endemic which delayed their diagnosis of Lassa fever[8] [24]. In…”

mentioning

confidence: 99%

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Clinical Presentations of Lassa Fever in Non-Endemic Parts of the World: A Systematic Review

Chime¹,

Chime²,

Ezeanolue³

2022

IJCM

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Background: Lassa fever cases outside Africa are seen as imported cases of Lassa fever. Timely diagnosis of imported Lassa fever is important for timely intervention necessary to reduce the morbidity and mortality associated with Lassa fever, and this requires the knowledge of the clinical manifestations of Lassa fever. Purpose: This review was done to see how clinical diagnosis of imported Lassa fever can be facilitated based on the clinical presentations of imported cases of Lassa fever in Lassa fever non-endemic region. Methods:The relevant articles for the review were obtained from the databases of PubMed and Google Scholar. Results: The clinical presentations of the imported Lassa fever cases consisted of multisystem involvement and were similar to those of Lassa fever patients who were treated in the Lassa fever endemic region. Conclusions: History of recent travel to, or residence in, Lassa fever endemic region is an important clue for clinical diagnosis of Lassa fever. The 2011 CDC surveillance case definition and the modified Khan case definition for Lassa fever may aid clinical diagnosis of Lassa fever. Any clinically suspected case of Lassa fever should have a laboratory confirmation.

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Section: Findings Of Clinical Features Of Lassa Fever Cases Inmentioning

confidence: 93%

mentioning

confidence: 99%

Clinical Presentations of Lassa Fever in Non-Endemic Parts of the World: A Systematic Review

Chime¹,

Chime²,

Ezeanolue³

2022

IJCM

View full text Add to dashboard Cite

show abstract

“…5 Like with EVD, exported cases of LF have also been reported, including a case in 2015 in New Jersey. 6 The following year, the first case of LF transmission outside of Africa was documented in Germany in an undertaker who worked with the body of a deceased LF patient from Togo. 7 Many viral hemorrhagic fevers, including EVD and LF, present with clinical signs and symptoms that overlap with those of common tropical diseases, especially malaria.…”

Section: Introductionmentioning

confidence: 99%

Methanol Fixation, but not Giemsa Staining, Inactivates Ebola and Lassa Viruses in Peripheral Blood Smears Made on Plastic Microscope Slides

Relich

Feldmann

Haddock

2020

The American Journal of Tropical Medicine and Hygiene

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Diseases caused by many highly pathogenic viruses, including Ebola virus (EBOV) and Lassa virus (LASV), present with nonspecific signs and symptoms that overlap with common tropical diseases such as malaria. Initial diagnostic tests performed on patients under investigation for viral hemorrhagic fevers routinely include analysis of peripheral blood smears to detect and quantify Plasmodium species. In light of recent and ongoing Ebola virus disease and Lassa fever epidemics, clinical laboratories around the world require protocols for dealing with highly infectious specimens from patients with suspected or confirmed high-consequence diseases. Few validated protocols for safe analysis of peripheral blood smears are available, revealing a need for further research. In this study, we evaluated the performance of two plastic microscope slide types that offer safe alternatives to glass slides, determined the temporal parameters required to inactivate EBOV and LASV in thin blood smears by methanol fixation, and assessed the virucidal activity of Giemsa stain. Both types of plastic microscope slides performed optimally; there were no significant differences in blood cell morphology or tinctorial properties nor were differences noted in Plasmodium ovale morphology or staining, when compared with glass slides. For both EBOV and LASV, viable viruses were not detected in thin blood smears following fixation in absolute methanol for at least 2 minutes. By contrast, viable EBOV and LASV were recovered from all Giemsa-stained thick blood smears.

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Epidemiology of Lassa Fever

Bell-Kareem

Smither

2021

Lassa Fever: Epidemiology, Immunology, Diagnostics, and Therapeutics

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Case Report: Imported Case of Lassa Fever — New Jersey, May 2015

Cited by 8 publications

References 14 publications

Clinical Presentations of Lassa Fever in Non-Endemic Parts of the World: A Systematic Review

Clinical Presentations of Lassa Fever in Non-Endemic Parts of the World: A Systematic Review

Methanol Fixation, but not Giemsa Staining, Inactivates Ebola and Lassa Viruses in Peripheral Blood Smears Made on Plastic Microscope Slides

Epidemiology of Lassa Fever

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