Case Report: Implantation of Dedifferentiated to Poorly Differentiated Thyroid Carcinoma After Endoscopic Thyroid Surgery

Hu, Jin; Xu, Xia; Wang, Shuntao; Fang, Dong; Zhang, Ximeng; Ming, Jie; Huang, Tao

doi:10.3389/fonc.2022.896942

Cited by 3 publications

(6 citation statements)

References 14 publications

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“…[ 146 ]. This is also depicted in our review, where few patients went disease-free [ 36 , 39 , 45 , 52 , 53 , 54 , 56 , 58 , 59 , 64 , 65 , 68 , 71 , 72 , 87 , 96 , 99 , 103 , 104 , 106 , 108 , 117 , 118 ]. Distant metastases represent the most significant cause of death in PDTC, with the majority of patients succumbing to the disease.…”

Section: Discussionsupporting

confidence: 78%

“…However, it remains debatable whether the cut-off value for the poorly differentiated area should be reported in PDTC tumors. Based on our review, several cases had a multiconstituent histology of well-differentiated (mostly PTC and FTC) with poorly differentiated areas without elaborating on their extent [ 49 , 50 , 55 , 56 , 58 , 69 , 71 , 72 , 73 , 91 , 100 , 103 , 107 , 109 , 112 , 113 ]. Interestingly, the Japanese society of thyroid surgery emphasizes that the presence of a poorly differentiated component should be acknowledged as a distinct entity from DTC, independent of its histological extent within the tumor [ 128 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the majority of studies in our review, the extent of the poorly differentiated area was not reported, and a PDTC definition was decided to address this component. A large number of patients with PDTC reviewed herein presented with locally advanced disease (T3 or T4, extrathyroidal extension, and nodal involvement) [ 40 , 44 , 46 , 47 , 49 , 50 , 51 , 54 , 55 , 57 , 58 , 60 , 61 , 62 , 64 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 75 , 76 , 77 , 78 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 90 , 91 , 92 , 94 , 97 , 98 , 99 , 100 , 101 , 102 , 107 , 108 , 109 , 111 , 112 , 113 , 114 , 115 , 116 ,…”

Section: Discussionmentioning

confidence: 99%

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The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

Violetis,

Konstantakou,

Spyroglou

et al. 2024

JPM

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Background: Poorly differentiated thyroid carcinoma (PDTC) has an intermediate prognosis between indolent well-differentiated thyroid carcinoma (TC) and anaplastic carcinoma. Herein, we present a case report with a PDTC component, along with a systematic review of the literature. Case Report: We report a case of a 45-year-old man diagnosed with a PDTC component, along with hobnail and tall-cell variant features positive for BRAFV600E mutation, after a total thyroidectomy and neck dissection. Radioactive iodine (RAI)-131 therapy was applied, but an early recurrence led to complementary surgeries. The anti-Tg rise, the presence of new lymph nodes, and the negative whole-bodyradioiodine scan were suggestive of a radioiodine-resistant tumor. Lenvatinib, sorafenib, dabrafenib/trametinib, cabozantinib and radiotherapy were all administered, controlling the tumor for a period of time before the patient ultimately died post-COVID infection. Systematic Review: We searched PubMed, Scopus, and WebofScience to identify studies reporting clinicopathological characteristics, molecular marker expression, and management of non-anaplastic TC with any proportion of PDTC in adult patients. Of the 2007 records retrieved, 82were included in our review (PROSPERO-ID545847). Conclusions: Our case, together with the systematic review, imply that a combination of molecular-targetedtreatments may be safe and effective in patients with RAI-resistantBRAF-mutated advanced PDTC when surgery has failed to control tumor progression.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

Violetis,

Konstantakou,

Spyroglou

et al. 2024

JPM

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“…A comprehensive literature search on implantation of thyroid tissue secondary to thyroid procedures was performed in PubMed from January 1976 to September 2023. The keywords used were “thyroid,” “implantation,” “metastasis,” “thyroidectomy,” “extra‐thyroid,” “endoscopic surgery,” and “needle.” Finally, 29 relevant articles with 47 patients were identified 5–33 . The characteristics of the included studies had been summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous implantation of nodular goiter after transoral endoscopic thyroidectomy vestibular approach: A case study and review of literature

Weng,

Kwan,

Chen

et al. 2024

Head & Neck

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BackgroundExtrathyroid implantation or dissemination of thyroid tissue secondary to a thyroid procedure is rare. Most of these belonged to thyroid carcinoma with metastatic potential and uncommon for benign pathologies.MethodsWe report the case of a 31‐year‐old female who was identified to have multiple subcutaneous implantation of thyroid tissue 5 years after transoral endoscopic thyroidectomy vestibular approach. A comprehensive literature search on implantation of thyroid tissue secondary to thyroid procedures was performed.ResultsAccidental tearing of the capsule during previous surgery may lead to the subcutaneous implantation. Through literature review, a total 29 articles with 47 patients were identified. 33.3% were benign lesions, and implantation was mostly secondary to fine needle aspiration biopsy (46.5%).ConclusionsSubcutaneous or port site implantation after endoscopic thyroid surgery may occur in benign thyroid pathologies and therefore, oncologic principles must be strictly followed during surgery regardless of its histopathological nature.

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“…In endoscopic thyroid surgery, surgeons usually perform central compartment lymph node dissection after tumor resection due to the relatively narrow operation space and unskilled operation. There are several reports of tumor implantation metastasis after endoscopic thyroidectomy (12)(13)(14)(15)(16)(17). En bloc resection emphasizes the removal of the primary tumor, adjacent normal tissue, and lymphoid adipose tissue as a whole, with the aim of avoiding tumor fragmentation and implantation metastasis.…”

Section: Introductionmentioning

confidence: 99%

En bloc resection of total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach in papillary thyroid carcinoma

Sheng

Li²,

Fang³

et al. 2023

Front. Endocrinol.

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IntroductionThe current study presents a preliminary exploration of en bloc resection via a gasless transoral approach in papillary thyroid carcinoma.ObjectiveThis study aimed to summarize and explore the efficacy and safety of en bloc resection of total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach in patients with papillary thyroid carcinoma.MethodsThis study was conducted between January 2021 and December 2021. It involved 30 patients with bilateral papillary thyroid carcinoma who had undergone en bloc resection of the total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach using a three-trocar and four-instrument technique at The First Affiliated Hospital of the University of Science and Technology of China. The key steps and difficulties of the operation were summarized, and the clinicopathological characteristics and surgical complications of patients were analyzed.ResultsAll operations were successful without conversion to open surgery. The pathological diagnosis was bilateral papillary thyroid carcinoma. The mean maximum tumor diameter was 0.85 ± 0.51 cm (range 0.3–2.5 cm). There was no case of gross capsular invasion. The mean number of harvested central compartment lymph nodes was 11.36 ± 5.36. Central compartment lymph node metastases were found in 16 patients (53.3%) with a mean of 1.53 ± 2.39. On the other hand, lymphocytic thyroiditis was observed in 12 cases (40%), and microscopic capsular invasion was observed in five cases (16.6%). All patients had normal parathyroid hormone levels after the operation. However, one patient developed hoarseness after the operation due to injury of the recurrent laryngeal nerve branch, but there was no numbness of the mandible and lower lip or infection of the oral incision.ConclusionThe study revealed that the three-trocar and four-instrument technique can be used in the en bloc resection of total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach without disconnecting the thyroid isthmus. As a result, the operation is considered effective and safe. Therefore, this technique may be a better surgical method for patients with bilateral thyroid cancer and cosmetic needs.

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Case Report: Implantation of Dedifferentiated to Poorly Differentiated Thyroid Carcinoma After Endoscopic Thyroid Surgery

Cited by 3 publications

References 14 publications

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

Subcutaneous implantation of nodular goiter after transoral endoscopic thyroidectomy vestibular approach: A case study and review of literature

En bloc resection of total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach in papillary thyroid carcinoma

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