Case Report: Identification of Potential Prognosis-Related TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next Generation Sequencing: Two Cases

Zhang, Yi; Ma, Liang; Liu, Jie; Zhu, Huijuan; Lü, Lin; Deng, Kan; Ma, Wenbin; Pan, Hui; Wang, Renzhi; Yao, Yong

doi:10.3389/fendo.2021.673908

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…B-cell lymphoma is the most common cell type of primary pituitary lymphoma, followed by T-cell and NK/T-cell types [ 52 ]. The prognosis is worse for the primary form, with TP53 mutations and BCL6-LPP fusions reportedly associated with worse prognosis [ 55 ].…”

Section: Lymphomamentioning

confidence: 99%

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Tsukamoto¹,

Miki²

2023

Jpn J Radiol

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Many types of tumors can develop in the pituitary gland. In the recently revised 5th editions of the World Health Organization (WHO) classifications (2021 WHO Classification of Central Nervous System Tumors and the 2022 WHO Classification of Endocrine and Neuroendocrine Tumors), various changes have been made to the tumors other than pituitary neuroendocrine tumor (PitNET)/pituitary adenoma, as well as PitNET. Adamantinomatous craniopharyngioma and papillary craniopharyngioma are now considered separate tumors in the 5th edition of the WHO classification. Tumors positive for thyroid transcription factor 1, a marker of posterior pituitary cells, are now grouped together in the pituicyte tumor family in the 5th edition of the WHO classification of Endocrine and Neuroendocrine Tumors. Poorly differentiated chordoma is newly listed in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors. In this paper, we present the latest WHO classification of pituitary tumors (adamantinomatous craniopharyngioma, papillary craniopharyngioma, pituitary blastoma, pituicyte tumor family, tumors of pituitary origin other than those of the pituicyte tumor family, germinoma, meningioma, chordoma, metastatic tumors, lymphoma, and pituitary incidentaloma), review diseases requiring differentiation from tumors (pituitary abscess, hypophysitis, pituitary hyperplasia, Rathke’s cleft cyst, arachnoid cyst, and aneurysm), and discuss diagnoses based on imaging findings.

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Section: Lymphomamentioning

confidence: 99%

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Tsukamoto¹,

Miki²

2023

Jpn J Radiol

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“…In the literature, only 57 PPL cases have been reported, and 34 of these cases had ophthalmological symptoms. Only 18 of these reported cases included pre-and postoperative ophthalmological examination (Table 1) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. This is the first study to investigate and review treatment responses to the ophthalmological symptoms of PPL patients.…”

Section: Discussionmentioning

confidence: 99%

“…Primary pituitary lymphoma (PPL) is a localized lymphoma in the pituitary gland, which lacks systemic involvement [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. It is an extremely rare tumor, with only 57 reported cases in English literature to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Treatment Response to Acute Total Ophthalmoplegia in Primary Pituitary Lymphoma: A Case Report and Review of the Literature

Uygur,

Karataş,

Arslan

et al. 2024

Cureus

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Primary pituitary lymphoma (PPL) is an extremely rare localized lymphoma without systemic involvement. The most common clinical presentations of PPL are hypopituitarism, headaches, and ophthalmoplegia. Diagnosing PPL without a biopsy is almost impossible. There is no study that has specifically investigated and reviewed treatment responses to the ophthalmological symptoms of PPL patients. Herein, we present a 66-year-old female patient who had acute-onset total ophthalmoplegia and headache as admission symptoms, which was diagnosed as PPL after subtotal resection. In the present study, we discussed the response of ophthalmological symptoms to treatment with a review of the literature. Only 18 reported cases had postoperative ophthalmological examination, and in 94.4% of these cases, ophthalmoplegia resolves after surgery and chemotherapy. The complete resection rate of the PPL in the literature was found to be as low as 12.3% in this region because of the hard and adhesive nature of the tumor. Our review unveiled that complete recovery of ophthalmoplegia can be achieved even in the late phase of the symptoms. In the present case, ophthalmoplegia resolved completely following subtotal resection and rituximab, high-dose methotrexate, and cytarabine treatment.

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“…PPL should be managed based on the protocol for treating PCNSL, including surgery, chemotherapy, and/or radiotherapy ( 15 , 21 ). As PPL is invasive and multifocal, the lesion cannot be completely removed by surgery.…”

Section: Discussionmentioning

confidence: 99%

Primary pituitary stalk mucosa-associated lymphoid tissue lymphoma: a case report and literature review

et al. 2023

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BackgroundPrimary extranodal mucosa-associated lymphoid tissue (MALT) lymphoma in the sellar region is a rare indolent B-cell lymphoma.Case presentationA newly diagnosed patient with MALT lymphoma originating from the pituitary stalk is reported. A space-occupying lesion in the sellar region was found in a 24 year-old man who had no clinical symptoms except for those relating to a sex hormone disorder (rising estrogen and falling androgen) identified during a pre-employment physical examination. MALT lymphoma was diagnosed pathologically. Radiotherapy and chemotherapy were proposed after surgery. However, the patient selected androgen replacement therapy only rather than chemoradiotherapy. Over the next 3 months, no visual disturbance, headache, cranial nerve abnormality, or other symptoms occurred.ConclusionPrimary sellar region MALT lymphoma is an extremely rare disease. The differential diagnosis of sellar and parasellar masses should include primary sellar region MALT lymphoma. Early detection and treatment of this lymphoma can effectively improve the prognosis.

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Case Report: Identification of Potential Prognosis-Related TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next Generation Sequencing: Two Cases

Cited by 5 publications

References 23 publications

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Treatment Response to Acute Total Ophthalmoplegia in Primary Pituitary Lymphoma: A Case Report and Review of the Literature

Primary pituitary stalk mucosa-associated lymphoid tissue lymphoma: a case report and literature review

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