Case Report: Hypoparathyroidism with Menses-Associated Hypocalcemia

Le, Mallette

doi:10.1097/00000441-199207000-00009

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…Subsequently, similar observations were made in IHP and ‘autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy’ associated hypoparathyroidism [16,20]. However, there are only two reports systematically assessing changes in serum calcium in patients with hypoparathyroidism during menstrual cycle [19,20]. Graham et al .…”

Section: Discussionmentioning

confidence: 72%

“…The authors suggested PMS as the possible reason for the hypocalcemic symptoms during menstruation in hypoparathyroidism [19]. On the contrary, Mallette LE reported a fall in SiCa ++ and increased muscle stiffness and during menstruation in a patient with IHP [20]. …”

Section: Discussionmentioning

confidence: 99%

“…A subset of the patients complained of hypocalcemic symptoms in the perimenstrual phase. Though several investigators have reported similar clinical observation [14-18], there is only one systematic study and an isolated case report investigating relationship of serum calcium with menstruation in patients with hypoparathyroidism [19,20] and the results were variable. It was also suggested that hypocalcemic symptoms during perimenstrual phase might be a reflection of PMS rather than hypocalcemia [19].…”

Section: Introductionmentioning

confidence: 99%

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Menstruation associated hypocalcemic symptoms and serum calcium in patients with idiopathic hypoparathyroidism

Saha

Goswami

2014

BMC Endocr Disord

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BackgroundSome of the patients with idiopathic hypoparathyroidism (IHP) report symptoms of hypocalcemia during menstruation. There is limited data on this observation.MethodsTwenty six menstruating women with IHP and 26 healthy controls were questioned regarding symptoms suggestive of hypocalcemia during menstruation. Twelve patients and eight controls were asked to prospectively monitor symptoms suggestive of hypocalcemia and premenstrual syndrome (PMS) if any, over two consecutive menstrual cycles. Serum ionized calcium (SiCa++), total and albumin adjusted calcium and intact paratharmone (iPTH) were measured at eight points covering menstrual, immediate post-menstrual, mid-cycle and premenstrual phase.ResultsTwelve of the 26 (46.2%) patients with IHP reported hypocalcemic symptoms during menstruation as compared to none of the controls. During prospective monitoring, there was no specific trend of hypocalcemic symptoms with respect to the phase of menstrual cycle. The mean SiCa++, serum total and albumin-adjusted calcium, iPTH and inorganic-phosphorus measured over two menstrual cycles were not significantly different in either of the two study groups. None of the subjects had PMS.ConclusionWomen with IHP do not show any trend of hypocalcemic symptoms or fluctuations in serum calcium over different phases of menstrual cycles. Therefore, patients with hypoparathyroidism linking hypocalcemic symptoms with menstruation should be reassured regarding lack of this association.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Menstruation associated hypocalcemic symptoms and serum calcium in patients with idiopathic hypoparathyroidism

Saha

Goswami

2014

BMC Endocr Disord

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“…261 In contrast, at the time of the menses, when estrogen levels are low, some well-treated women with hypoparathyroidism may develop symptomatic hypocalcemia. 262 The same phenomenon occurs occasionally in women with PHP. There are conflicting reports of the effect(s) of pregnancy on mineral metabolism in women with PHP.…”

Section: Diagnosis Of Pseudohypoparathyroidismmentioning

confidence: 88%