Case Report: Fulminant Hepatitis C Viral Infection After Allogeneic Bone Marrow Transplantation

Kanamori, Heiwa; Fukawa, H; Maruta, Atsuo; Harano, Hiroshi; Kodama, Fumio; Matsuzaki, Michio; Miyashita, Hiroko; Motomura, Shigeki; Ōkubo, Takao; Yoshiba, Makoto; Sekiyama, Kazuhiko

doi:10.1097/00000441-199202000-00009

Cited by 60 publications

(30 citation statements)

References 11 publications

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“…Two patients in the GϩCϩ group developed fulminant hepatitis and died on days 139 and 148, respectively, which has been described elsewhere. 10 There was no significant difference in post-transplant GPT levels between the GϩCϪ group and the GϪCϪ group at any time point.…”

Section: Clinical Course and Analysis Of Liver Functionmentioning

confidence: 73%

“…[11][12][13]15 Two patients in the GϩCϩ group developed fulminant hepatitis and died on days 139 and 148. 10 We think it would be reasonable, from comparison between the GϩCϩ group and the GϩCϪ group, to say that the fulminant hepatitis in these two patients should be ascribed to HCV infection and not HGV infection, although there is a report which suggests that HGV can be responsible for fulminant hepatitis. 16 We excluded one patient from the final analysis of the data with HGV-RNA(ϩ)HCVϪRNA(Ϫ) who showed marked elevations of GPT levels during the clinical course after BMT.…”

Section: Discussionmentioning

confidence: 89%

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Long-term liver function of recipients with hepatitis G virus infection after bone marrow transplantation

Maruta

Tanabe

Hashimoto

et al. 1999

Bone Marrow Transplant

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Summary:To clarify the role of hepatitis G virus (HGV) infection in liver dysfunction following allogeneic BMT, we examined cryopreserved serum samples from 33 patients who had a history of blood transfusions before BMT and whose serum samples had been stored periodically, before BMT, on day 100, and thereafter for the presence of HGV-RNA and hepatitis C virus (HCV)-RNA by reverse transcription polymerase chain reaction. Nineteen patients (58%) out of 33 were positive for HGV-RNA before BMT and 10 for HCV-RNA. All patients positive for HCV-RNA were also positive for HGV-RNA. Patients were divided into three groups according to their viral status before BMT; namely, the G؉C؉ group (n = 10), the G؉C؊ group (n = 9) and the G؊C؊ group (n = 14). Two patients in the G؊C؊ group became positive for HGV-RNA after BMT. One patient in the G؉C؊ group suffered an acute exacerbation of hepatitis, with GPT levels reaching over 1000 IU/l, 2 and 3 years after BMT, showing quite a different clinical course from those in the G؉C؊ group. Excluding these three patients, GPT levels of the patients in the G؉C؉ group were significantly higher after day 100 and remained higher than those of patients in the G؉C؊ and G؊C؊ groups for at least 4 years. There were no significant differences in post-transplant GPT levels between the G؉C؊ group and the G؊C؊ group at any time point. Of the seven patients followed-up for 5 to 10 years, three patients became HGV-RNA-negative, while four remained positive. In the absence of HCV co-infection, the behavior of GPT values post transplant in patients with HGV infection did not differ from those without HGV infection. With respect to the patient who was G؉C؊ and showed high values of GPT 2 and 3 years post transplant, we suspect that his liver dysfunction might have been caused by some unknown virus or etiology. Keywords: GBV-C; HGV; BMT; liver function Correspondence: A Maruta, Department of Hematology/Chemotherapy, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama 241-0815, Japan Received 6 November 1998; accepted 15 March 1999Two hepatitis-associated viruses, GB virus C (GBV-C) and hepatitis G virus (HGV), were identified in 1995 and in 1996. 1,2 These two viruses were found to show a 95% nucleotide homology, which was thought to indicate that they were isolates of the same virus, members of the Flaviviridae family.

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Section: Clinical Course and Analysis Of Liver Functionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 89%

Long-term liver function of recipients with hepatitis G virus infection after bone marrow transplantation

Maruta

Tanabe

Hashimoto

et al. 1999

Bone Marrow Transplant

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“…Reverse seroconversion of HBV is not a rare complication in autologous HSCT, 43 and in allogeneic HSCT recipients the risk seems to be higher during the tapering of the immunosuppressive therapy. 42 Moreover, in this setting, fulminant hepatitis due to HCV 44,45 or HBV 46 has been described. Therefore, even if infection with hepatotropic viruses does not represent a major contraindication for HSCT, 47 a careful follow-up is recommendable, especially during immunosuppression tapering.…”

Section: Hepatitis Viruses In Autologous and Allogeneic Hsctmentioning

confidence: 99%

Rare viral infections in children receiving hemopoietic stem cell transplant

Castagnola

Faraci

Moroni

et al. 2008

Bone Marrow Transplant

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“…Hepatitis reactivation was a common event, mainly seen to occur after immune reconstitution, as suggested by the median timing of hepatic deterioration (68 days post-BMT) observed in the group with liver failure resulting from subacute hepatitis, in accordance with previous reports. 7,15,16 This finding suggests that careful monitoring of such patients is needed during the tapering of immunosuppressive drugs given for GVHD prophylaxis, to avoid an abrupt and possibly dangerous recovery of immunocompetence. In order to assess if, how and when immunosuppressive therapy could be discontinued without a major risk for life-threatening reactivation, our observation in this study cohort is ongoing.…”

mentioning

confidence: 99%

“…15,16 McDonald et al 17 reported that pre-transplant non-A, non-B hepatitis correReferences lated with a high prevalence of VOD events, and the presence of abnormal transaminase levels before BMT with evi-…”

mentioning

confidence: 99%

Hepatitis C virus genotypes and liver disease in patients undergoing allogeneic bone marrow transplantation

Locasciulli

Testa

Pontisso

et al. 1997

Bone Marrow Transplant

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Summary:patients 1-3 particularly when identified by the detection of HCV-RNA in serum by PCR. 4,5 It has been suggested that HCV infection may represent an independent risk factor for Hepatitis C virus (HCV) genotypes were investigated in 57 HCV-infected patients undergoing allogeneic BMT liver failure after BMT, 4 but this assumption is controversial and different results have been reported from differat four European BMT units where death resulting from liver failure (LF) in HCV-infected patients varied ent BMT units. [5][6][7] Since an association between HCV genotypes and from Ͻ1% to Ͼ80%. The aim of the study was to determine whether differing HCV genotypes could account degrees of cytopathogenicity has previously been indicated, particularly in immunosuppressed patients, 8,9 and considerfor the different severity of post-transplant liver disease (LD). Sera from patients with pre (n = 22) or post-BMT ing that their geographical distribution differs widely, 10 this raises the question of their role in determining the severity (n = 35) HCV infection were collected from Italy (Genova, Monza

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Case Report: Fulminant Hepatitis C Viral Infection After Allogeneic Bone Marrow Transplantation

Cited by 60 publications

References 11 publications

Long-term liver function of recipients with hepatitis G virus infection after bone marrow transplantation

Long-term liver function of recipients with hepatitis G virus infection after bone marrow transplantation

Rare viral infections in children receiving hemopoietic stem cell transplant

Hepatitis C virus genotypes and liver disease in patients undergoing allogeneic bone marrow transplantation

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