Case Report Familial primary open-angle glaucoma: a case report

Abstract

ABSTRACT. Primary open-angle glaucoma (POAG) is a disease that is often inherited, but the rules governing its inheritance are inconclusive. Herein, we report a case of POAG in a Chinese family. A 25-year-old female patient was referred to our department with progressive visual acuity decline in her left eye for the past 3 years. Ophthalmological examination supported our diagnosis of POAG in both eyes. We recorded the case history and clinical data of the proband and her family members and followed standard genetic study procedures. In this family, there were 8 individuals (4 male and 4 female) diagnosed with POAG, 2 of whom died. Genetic analysis revealed that the inheritance pattern of POAG in this family is autosomal dominant.

Familial primary open-angle glaucoma: A case report

“…Intraocular pressure-induced stress and strain may result in compression, deformation, and remodeling of the lamina cribrosa with consequent mechanical axonal damage and disruption of axonal transport that interrupts retrograde delivery of essential trophic factors to retinal ganglion cells from their brainstem target (relay neurons of the lateral geniculate nucleus) [11] . Shi et al [12] reported a case of POAG in 25-years-old female patient. Ophthalmological examination supported diagnosis of POAG in both eyes.…”