Case report: coeliac disease as a cause of secondary failure of glibenclamide therapy in a patient with permanent neonatal diabetes due to KCNJ11/R201C mutation

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of monogenic diabetes in children and adolescents

“…The only side effects reported to date are transient diarrhea and staining of the teeth 73,74 . Recently, it has been reported that celiac disease my cause secondary SU failure not explained by lack of adherence to therapy 75 Insulin secretion in children with diabetes treated with adequate SU doses seems to be driven mostly by food intake via non‐KATP dependent pathways.…”

“… 73 , 74 Recently, it has been reported that celiac disease my cause secondary SU failure not explained by lack of adherence to therapy. 75 Insulin secretion in children with diabetes treated with adequate SU doses seems to be driven mostly by food intake via non‐KATP dependent pathways. Meals composed of either all carbohydrate or only protein/fat resulted in similar insulin responses, highlighting the importance of carbohydrate intake with most meals to avoid post‐prandial hypoglycemia.…”

“… 73 , 74 Recently, it has been reported that celiac disease my cause secondary SU failure not explained by lack of adherence to therapy. 75 …”