Case report and review of the literature: Secretory breast cancer in a 13-year-old boy—10 years of follow up

Cabello, César; Alvarenga, Marcelo; Alvarenga, César Augusto; Duarte, Giuliano Mendes; Pereira, Patrick Nunes; Marshall, Priscila Silva

doi:10.1007/s10549-011-1869-4

Cited by 15 publications

(32 citation statements)

References 36 publications

(94 reference statements)

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“…SBC is also known to occur in both sexes with prior literature showing a male to female ratio of 1:6 [6], our review of the NCDB demonstrated a ratio of 1:31. Multiple case reports have been reported in the literature [7,[8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Rare breast cancer: 246 invasive secretory carcinomas from the National Cancer Data Base

Jacob

Hodge

Franko

et al. 2016

Journal of Surgical Oncology

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Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Rare breast cancer: 246 invasive secretory carcinomas from the National Cancer Data Base

Jacob

Hodge

Franko

et al. 2016

Journal of Surgical Oncology

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“…As a low-grade carcinoma, SCB has an indolent course and good long-term survival. The prognosis is generally considered to be better in children and adolescents, relatively poor in adults, and distant metastasis is rarely observed (32,33). Axillary lymph node involvement has been reported in 30% of the cases (33), particularly those with primary tumors > 2 cm in diameter.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Primary Breast Cancer: A Case Report and Literature Review

Fan

Liang

et al. 2020

Preprint

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BackgroundInvasive micropapillary carcinoma (IMPC) and secretory carcinoma of the breast (SCB) are relatively rare types of breast cancer. IMPC is usually associated with high incidence of lymphovascular invasion, lymph node metastasis and poor prognosis. While SCB usually carries a relatively favorable prognosis, cases of axillary and distant metastases have been reported. Clinicians generally adopt systemic treatments based on the histopathological findings of the patients to improve the prognosis, but there is currently no consensus on the optimal treatment for these two types of cancer.Case presentationWe treated a 50‐year‐old woman with lung cancer history who presented with a single lump in each breast. Following bilateral breast-conserving surgery, the diagnosis of SCB of the left breast and IMPC of the right breast was confirmed with immunohistochemistry. It is worth noting that the pathological results of left lung adenocarcinoma centered on micropapillary-type was same as the invasive micropapillary component of right breast.ConclusionsWe reported this case of bilateral primary relatively-rare-form breast cancer for its extremely rare occurrence and there are less than 20 cases of SCB reported worldwide till now. It is also significative to distinguish this primary tumor of right breast from metastatic cancer. Our histopathologic diagnosis and synthetical therapy scheme will provide material for SCB and IMPC. To facilitate the diagnosis and prognosis of such relatively rare tumors, more cases will need to be reported.

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“…Secretory breast carcinoma can present at any age, in both males and females, with a ratio of approximately 1:2 (Table ) to 1:6 . The primary tumor commonly presents as a slow growing, painless, mobile, palpable well‐circumscribed mass located in the left and right breast with equal frequency .…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…There are reports of using systemic therapy, but this should be discouraged based on the indolent prognosis, nonresponsiveness, and low metastatic risk of these tumors . There have been no documented reports showing added benefit of adjuvant chemotherapy and therefore is no evidence for its role in treatment .…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…This was first described by McDivitt and Stewart in 1966, when they observed seven cases of “juvenile breast cancer” in females between the ages of 3‐15 years with similar clinical and histological presentations . Tavassoli and Norris later described the abundant eosinophilc secretions within intracellular vacuoles and intercellular spaces commonly present in both females and males of all ages, and coined the term “secretory carcinoma.” Now, roughly two‐thirds of the published cases of SBC are in the adult population, with a mean age of 56 years …”

Section: Introductionmentioning

confidence: 99%

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Secretory breast carcinoma in an 8-year-old girl: A case report and literature review

et al. 2018

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Secretory breast carcinoma (SBC) is a rare form of breast cancer found in both children and adults, and is the most common breast cancer in the pediatric population.Although SBC usually carries a favorable prognosis, there have been reported cases of axillary and distant metastases. Surgery is the primary mode of treatment, however, there exists variability within the literature surrounding the management of SBC. We report a case of an 8-year-old girl who presented with a firm, mobile, palpable breast mass. Ultrasonography was performed, followed by local excision, with surgical pathology concerning for SBC. The patient was definitively treated with mastectomy and sentinel lymph node (SLN) biopsy. She received no adjuvant therapies and 2 years later, remains disease free. Herein, we review the literature, curate data from 89 reported cases of pediatric and adult SBC, and address some of the controversy surrounding its treatment. From this review we conclude that patients with SBC should be reviewed at multidisciplinary treatment planning conference, undergo surgery with mastectomy or lumpectomy with SLN biopsy, and have longterm postoperative follow-up. K E Y W O R D Sbreast cancer, pediatric breast cancer, secretory breast carcinoma

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Case report and review of the literature: Secretory breast cancer in a 13-year-old boy—10 years of follow up

Cited by 15 publications

References 36 publications

Rare breast cancer: 246 invasive secretory carcinomas from the National Cancer Data Base

Rare breast cancer: 246 invasive secretory carcinomas from the National Cancer Data Base

Bilateral Primary Breast Cancer: A Case Report and Literature Review

Secretory breast carcinoma in an 8-year-old girl: A case report and literature review

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