Case Report and Review: Is the Tendency for Curvularia Tubular Obstruction Significant in Pathogenesis?

Diskin, Charles J.; Stokes, Thomas J.; Dansby, Linda M.; Radcliff, Lautrec; Carter, T.B.

doi:10.1177/089686080802800625

Cited by 3 publications

(4 citation statements)

References 18 publications

(23 reference statements)

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“…Peritonitis from filamentous fungal species such as Curvularia is much less common than that from Candida species,4 with only nine reported cases in the adult population and now two cases in pediatrics (Table I). 13, 14…”

Section: Case Reportmentioning

confidence: 99%

“…Curvularia species have presented as complications of peritoneal dialysis in three ways (Table I): 1) catheter obstruction; 2) catheter obstruction with peritonitis; and 3) peritonitis without obstruction 14. Some patients appeared more ill with peritoneal and systemic symptoms, whereas others reported only black “specks”in their effluent.…”

Section: Case Reportmentioning

confidence: 99%

“…Some patients appeared more ill with peritoneal and systemic symptoms, whereas others reported only black “specks”in their effluent. Of the 10 previously described patients, 7 reported seeing black proteinaceous material in the lumen of the Tenckhoff catheter 14–16…”

Section: Case Reportmentioning

confidence: 99%

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Black Specks in Dialysis Fluid: An Unusual Case of Peritonitis in a Pediatric Patient on Peritoneal Dialysis

Charlton

Barcia

Norwood

2010

Dialysis & Transplantation

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A 13‐year‐old boy resumed peritoneal dialysis after the loss of a deceased donor renal transplant but was main‐tained on mycophenolate mofetil and monthly infusions of intravenous immunoglobulin to reduce his panel reactive antibody level. He developed low‐grade fever, cloudy fluid, and abdominal pain without peritoneal signs. His mother reported seeing some black “flakes” in his effluent. He was admitted and treated for presumed bacterial peritonitis twice with neither bacterial nor fungal growth on cultures. He received empiric antibiotics and appeared to respond partially. The patient remained asymptomatic with little abdominal pain, but had progressive difficulties with drain‐age. A black “speck” was obtained and identified as Curvularia. The peritoneal dialysis catheter was removed, and he was treated with both intravenous and intraperitoneal amphotericin B. This is the second case of peritonitis caused by Curvularia in a pediatric peritoneal dialysis patient reported in the literature. peritonitis is a serious complication of peritoneal dialy‐Fungal sis. Filamentous species such as Curvularia are uncommon, with a total of 10 reported cases. Although it has been reported as a disseminated infection, it is rarely pathogenic in humans. Of the 10 reported cases, 7 reported the pres‐ence of black proteinaceous material in the lumen of the Tenckhoff catheter. The most important measure in the treatment of peritonitis caused by Curvularia is removal of the peritoneal dialysis catheter. Curvularia species have been found to be susceptible in vitro to many antifungals, but there is no standard for therapy. Black “specks” in dialysate effluent should raise the level of concern for fungal peritonitis. Dial. Transplant. © 2010 Wiley Periodicals, Inc.

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Black Specks in Dialysis Fluid: An Unusual Case of Peritonitis in a Pediatric Patient on Peritoneal Dialysis

Charlton

Barcia

Norwood

2010

Dialysis & Transplantation

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“…A Curvularia infection in humans is designated as curvulariosis, a subtype of phaeohyphomycoses (i.e., fungal infections caused by dematiaceous fungi) [3]. The resulting diseases include deep and disseminated infections [3,[17][18][19], infections complicating peritoneal dialysis [14,20,21], respiratory infections including sinusitis and bronchopulmonary mycosis [3,10,22], urinary tract infections [23], as well as localized infections affecting the skin, nail [4,24,25], and the eye. Among eye infections, the involvement of Curvularia spp.…”

Section: Introductionmentioning

confidence: 99%

New Species of the Genus Curvularia: C. tamilnaduensis and C. coimbatorensis from Fungal Keratitis Cases in South India

et al. 2019

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Members of the genus Curvularia are melanin-producing dematiaceous fungi of increasing clinical importance as causal agents of both local and invasive infections. This study contributes to the taxonomical and clinical knowledge of this genus by describing two new Curvularia species based on isolates from corneal scrapings of South Indian fungal keratitis patients. The phylogeny of the genus was updated based on three phylogenetic markers: the internal transcribed spacer (ITS) region of the ribosomal RNA gene cluster as well as fragments of the glyceraldehyde-3-phosphate dehydrogenase (gpdh) and translation elongation factor 1-α (tef1α) genes. The maximum likelihood phylogenetic tree constructed from the alignment of the three concatenated loci revealed that the examined isolates are representing two new, yet undescribed, Curvularia species. Examination of colony and microscopic morphology revealed differences between the two species as well as between the new species and their close relatives. The new species were formally described as Curvularia tamilnaduensis N. Kiss & S. Kocsubé sp. nov. and Curvularia coimbatorensis N. Kiss & S. Kocsubé sp. nov. Antifungal susceptibility testing by the broth microdilution method of CLSI (Clinical & Laboratory Standards Institute) revealed that the type strain of C. coimbatorensis is less susceptible to a series of antifungals than the C. tamilnaduensis strains.

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The prevalence and meaning of eosinophilia in renal diseases on a nephrology consultation service

Diskin

Stokes

Dansby

et al. 2011

Nephrology Dialysis Transplantation

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Case Report and Review: Is the Tendency for Curvularia Tubular Obstruction Significant in Pathogenesis?

Cited by 3 publications

References 18 publications

Black Specks in Dialysis Fluid: An Unusual Case of Peritonitis in a Pediatric Patient on Peritoneal Dialysis

Black Specks in Dialysis Fluid: An Unusual Case of Peritonitis in a Pediatric Patient on Peritoneal Dialysis

New Species of the Genus Curvularia: C. tamilnaduensis and C. coimbatorensis from Fungal Keratitis Cases in South India

The prevalence and meaning of eosinophilia in renal diseases on a nephrology consultation service

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