Case Report: An Acute Chikungunya Infection and a Recent Secondary Dengue Infection in a Peripartum Case in Ecuador

Farrell, Daniel F.; Lupone, Christina D.; Kenneson, Aileen; Cueva, Cinthya; Heydari, Naveed; Aguilera, Julio H. Barzallo; Polhemus, Mark E.; Endy, Timothy P.; Stewart-Ibarra, Anna M.

doi:10.4269/ajtmh.17-0781

Cited by 5 publications

(3 citation statements)

References 22 publications

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“… Carrillo-Hernández [ 109 ] Norte de Santander, Colombia August 2015 – April 2016 Cross sectional 157 12 7.6 26.81 PCR/PCR NM 42. Farrell [ 110 ] Machala, Ecuador 2015 Case report 1 1 NA 35 IgM, IgG ELISA/PCR NM 43. Gomez-Govea [ 111 ] Nuevo leon, Mexico Jan-Oct 2015 Cross sectional 101 5 5 31 median age IgM ELISA/IgM ELISA, PCR NM 44.…”

Section: Resultsmentioning

confidence: 99%

Global prevalence and distribution of coinfection of malaria, dengue and chikungunya: a systematic review

et al. 2018

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BackgroundMalaria, Dengue and Chikungunya are vector borne diseases with shared endemic profiles and symptoms. Coinfections with any of these diseases could have fatal outcomes if left undiagnosed. Understanding the prevalence and distribution of coinfections is necessary to improve diagnosis and designing therapeutic interventions.MethodsWe have carried out a systematic search of the published literature based on PRISMA guidelines to identify cases of Malaria, Dengue and Chikungunya coinfections. We systematically reviewed the literature to identify eligible studies and extracted data regarding cases of coinfection from cross sectional studies, case reports, retrospective studies, prospective observational studies and surveillance reports.ResultsCare full screening resulted in 104 publications that met the eligibility criteria and reported Malaria/Dengue, Dengue/Chikungunya, Malaria/Chikungunya and Malaria/Dengue/Chikungunya coinfections. These coinfections were spread over six geographical locations and 42 different countries and are reported more frequently in the last 15 years possibly due to expanding epidemiology of Dengue and Chikungunya. Few of these reports have also analysed distinguishing features of coinfections. Malaria/Dengue coinfections were the most common coinfection followed by Dengue/Chikungunya, Malaria/Chikungunya and Malaria/Dengue/Chikungunya coinfections. P. falciparum and P. vivax were the commonest species found in cases of malaria coinfections and Dengue serotype-4 commonest serotype in cases of dengue coinfections. Most studies were reported from India. Nigeria and India were the only two countries from where all possible combinations of coinfections were reported.ConclusionWe have comprehensively reviewed the literature associated with cases of coinfections of three important vector borne diseases to present a clear picture of their prevalence and distribution across the globe. The frequency of coinfections presented in the study suggests proper diagnosis, surveillance and management of cases of coinfection to avoid poor prognosis of the underlying etiology.Electronic supplementary materialThe online version of this article (10.1186/s12889-018-5626-z) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Global prevalence and distribution of coinfection of malaria, dengue and chikungunya: a systematic review

et al. 2018

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“…Ecuador in particular has a high burden of arboviral illness, with 86,306 total cases of dengue from 2014-2018 [6][7][8]. There is also a high prevalence of asymptomatic DENV infections and infections with other arboviruses in coastal Ecuador [1,9]. In 2014, CHIKV was introduced to Ecuador, with 35,555 cases from 2014-2018, followed by the introduction of ZIKV in 2016, with 5,304 cases from 2016-2018 [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Severity Index for Suspected Arbovirus (SISA): Machine learning for accurate prediction of hospitalization in subjects suspected of arboviral infection

et al. 2020

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Background Dengue, chikungunya, and Zika are arboviruses of major global health concern. Decisions regarding the clinical management of suspected arboviral infection are challenging in resource-limited settings, particularly when deciding on patient hospitalization. The objective of this study was to determine if hospitalization of individuals with suspected arboviral infections could be predicted using subject intake data. Methodology/Principal findings Two prediction models were developed using data from a surveillance study in Machala, a city in southern coastal Ecuador with a high burden of arboviral infections. Data were obtained from subjects who presented at sentinel medical centers with suspected arboviral infection (November 2013 to September 2017). The first prediction model-called the Severity Index for Suspected Arbovirus (SISA)-used only demographic and symptom data. The second prediction model-called the Severity Index for Suspected Arbovirus with Laboratory (SISAL)-incorporated laboratory data. These models were selected by comparing the prediction ability of seven machine learning algorithms; the area under the receiver operating characteristic curve from the prediction of a test dataset was used to

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“…Reports of altered cardiac symptoms in infants include tachycardia, heart murmur, hypertension, ventricular dysfunction, pericardial effusion, myocarditis, and death [ 32 , 33 , 42 , 45 , 51 , 54 , 57 , 58 , 60 , 63 , 69 , 78 ] ( Table 2 and Table 3 ). Pregnant mothers were reported to experience gestational hypertension, cardiorespiratory failure, and death [ 62 , 69 ] ( Table 2 and Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

Cardiomyopathy and Death Following Chikungunya Infection: An Increasingly Common Outcome

et al. 2021

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Chikungunya virus (CHIKV) is vectored by Aedes aegypti and Aedes albopictus mosquitoes and is found throughout tropical and sub-tropical regions. While most infections cause mild symptoms such as fever and arthralgia, there have been cases in which cardiac involvement has been reported. In adults, case reports include symptoms ranging from tachycardia and arrythmia, to myocarditis and cardiac arrest. In children, case reports describe symptoms such as arrythmia, myocarditis, and heart failure. Case reports of perinatal and neonatal CHIKV infections have also described cardiovascular compromise, including myocardial hypertrophy, ventricular dysfunction, myocarditis, and death. Myocarditis refers to inflammation of the heart tissue, which can be caused by viral infection, thus becoming viral myocarditis. Since viral myocarditis is linked as a causative factor of other cardiomyopathies, including dilated cardiomyopathy, in which the heart muscle weakens and fails to pump blood properly, the connection between CHIKV and the heart is concerning. We searched Pubmed, Embase, LILACS, and Google Scholar to identify case reports of CHIKV infections where cardiac symptoms were reported. We utilized NCBI Virus and NCBI Nucleotide to explore the lineage/evolution of strains associated with these outbreaks. Statistical analysis was performed to identify which clinical features were associated with death. Phylogenetic analysis determined that CHIKV infections with cardiac symptoms are associated with the Asian, the East Central South African, and the Indian Ocean lineages. Of patients admitted to hospital, death rates ranged from 26–48%. Myocarditis, hypertension, pre-existing conditions, and the development of heart failure were significantly correlated with death. As such, clinicians should be aware in their treatment and follow-up of patients.

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Case Report: An Acute Chikungunya Infection and a Recent Secondary Dengue Infection in a Peripartum Case in Ecuador

Cited by 5 publications

References 22 publications

Global prevalence and distribution of coinfection of malaria, dengue and chikungunya: a systematic review

Global prevalence and distribution of coinfection of malaria, dengue and chikungunya: a systematic review

Severity Index for Suspected Arbovirus (SISA): Machine learning for accurate prediction of hospitalization in subjects suspected of arboviral infection

Cardiomyopathy and Death Following Chikungunya Infection: An Increasingly Common Outcome

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