Case report: ALK-positive histiocytosis presented as bilateral synchronous breast masses with long-term remission on crizotinib
Yuhang Zhou,
Marisabel Hurtado-Castillo,
Om Pandey
Abstract:ALK-positive histiocytosis (APH) is a rare type of histiocytic neoplasm with characteristic ALK (Anaplastic Lymphoma Kinase) gene translocation and fusion, with only 27 reported cases in the literature. In this study, we report the first case of synchronous bilateral breast involvement of ALK-positive histiocytosis on initial presentation in a 46-year-old Hispanic woman. APH was diagnosed by the confirmation of clonal histiocyte proliferation with ALK overexpression on IHC and the presence of KIF5B-ALK gene fu… Show more
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