Case Report: Acute Intracardiac Thrombosis in Children With Coronavirus Disease 2019 (COVID-19)

Abstract

We herein describe a case series of children with SARS-CoV-2 infection (COVID-19) complicated with acute intracardiac thrombosis. The diagnosis of COVID-19 was confirmed through the reverse transcription-polymerase chain reaction (RT-PCR). Transthoracic echocardiography of patients revealed large intracardiac mobile masses resected successfully via cardiac surgery. The underlying mechanisms of this thrombus in the COVID-19 infection may be attributed to the hypercoagulation and inflammatory state of the disease incurred by the SARS-CoV-2 virus.

Linear mixed model analysis to evaluate correlations between remdesivir adverse effects with age and gender of patients with mild Covid‐19 pneumonia

“…Corona disease 2019 (Covid‐19), caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is a viral infection of the respiratory tract typified with fever, dry cough, fatigue, and worsening dyspnea. 1 During the current pandemic, several treatment protocols for Covid‐19 including chloroquine/hydroxychloroquine, favipiravir, lopinavir/ritonavir, and azithromycin have been tested and used. 2 Remdesivir, an adenosine triphosphate (ATP) analog that inhibits viral RNA polymerase, has been approved by the US Food and Drug Administration (FDA) for hospitalized patients with Covid‐19.…”

SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome

“…The child fulfilled all the current criteria for MIS-C, but as many clinical features are common with a bacterial septic shock, broad-spectrum antibiotics were used. The formation of a large cardiac thrombus in our case is noteworthy as this has been an uncommon complication in MIS-C 12 . Arrythmia has been reported to be one of the most frequent cardiovascular complications in MIS-C 7 , ventricular tachycardia has also been reported 9 .…”

Intracardiac thrombosis in the three-year-old boy with normal left ventricle systolic function in MIS-C associated with COVID-19

“…In compression to patients with COVID-19 (2.1%, 95% CI, 1% to 4%) and asymptomatic SARS-CoV-2 infection (0.7%, 95% CI, 0.1% to 2.4%), patients with MIS-C had the highest incidence at 6.5% (95% CI, 3% to 12%) of thrombotic events. 6 Among patients with thrombotic events (20 pts) only 3 had intracardiac thrombosis and associated comorbidities - two with acute COVID-19 and cancer, and one with MIS-C and obesity. All of those patients had catheter-related thrombosis.…”

“…All of those patients had catheter-related thrombosis. 6 Schroder J et al presented a healthy 17-years-old boy with systolic dysfunction of LV and a mural thrombus near the posteromedial papillary muscle in the LV apex. 7 Our patient had normal LV systolic function, but despite this, LV thrombus was developed at the time of intended discharge.…”