Case report: A unique case of benign teratoma in the posterior mediastinum associated with anterior meningomyelocele in a one-year-old child

Albrijawy, Reham; Alomar, Khaled; Aldeen, Rahaf Sharaf; Sharief, Fawaz A.L.; Marwa, Ghassan; Dalati, Husam

doi:10.1016/j.ijscr.2023.107914

Cited by 3 publications

(11 citation statements)

References 16 publications

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“…In the literature, this pathology has been documented only a few times in case reports and primarily in patients with NF1. 1 , 4 , 13 Here, we present a case of a nonsyndromic patient with an anterior cervicothoracic myelomeningocele and scoliosis, requiring surgical intervention due to progressive neurological decline. The patient’s progressive weakness was secondary to tethering of the herniated spinal cord within the meningocele sac.…”

Section: Discussionmentioning

confidence: 99%

Treatment of an anterior cervicothoracic myelomeningocele together with spine deformity correction in a child: illustrative case

Jackson,

Laxpati,

Bauer

2024

Journal of Neurosurgery: Case Lessons

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BACKGROUND Anterior cervicothoracic myelomeningoceles are a rare pathology. In reported cases, treatment has included shunting, isolated resection and repair without deformity correction, or isolated deformity correction without meningocele repair. The authors describe a pediatric patient with an anterior cervicothoracic myelomeningocele presenting with progressive neurological decline, who underwent simultaneous treatment of the myelomeningocele to detether the spinal cord and achieve major correction of the scoliotic deformity. OBSERVATIONS A 15-year-old girl was born with C7-T1-T2 hemivertebrae and anterior cervical myelomeningocele at C7–T1. She developed progressive cervical thoracic scoliosis, left hemiparesis initially, and additional right hemiparesis eventually. She underwent surgical repair via C7, T1, and T2 corpectomies with intradural detethering of the spinal cord. The scoliosis was treated with C7–T2 Ponte osteotomies and C2–T5 posterior fixation, followed by anterior reconstruction with a titanium cage and anterior plate from C6 to T3. The myelomeningocele was adequately treated with good correction of the patient’s deformity. The patient had postoperative improvement in her strength and solid arthrodesis on postoperative imaging. LESSONS The authors describe the successful treatment of an anterior cervicothoracic myelomeningocele and associated scoliosis in a child. This is a unique report of a combined strategy to achieve both deformity correction and detethering of the spinal cord.

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Section: Discussionmentioning

confidence: 99%

Treatment of an anterior cervicothoracic myelomeningocele together with spine deformity correction in a child: illustrative case

Jackson,

Laxpati,

Bauer

2024

Journal of Neurosurgery: Case Lessons

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“…Trychoptysis is a rare but pathognomonic symptom for PMTER that occurs when bronchial walls are perforated by teratomatous elements 53 . Recently, a case of meningomyelocele associated with a mature teratoma has been described in the posterior mediastinum 42 . Metastases of primary testicular or retroperitoneal GCTs must be ruled out.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Most PMGCTs develop in the anterior mediastinum 1,5 and only rarely in the posterior (paravertebral) mediastinum [42][43][44][45] or the middle (visceral) mediastinum. 46 Patients with PGMCTs can be asymptomatic for a long time and usually present with symptoms such as chest pain, chronic cough, dyspnoea and/or dysphagia.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…53 Recently, a case of meningomyelocele associated with a mature teratoma has been described in the posterior mediastinum. 42 Metastases of primary testicular or retroperitoneal GCTs must be ruled out. One study with 100 cases of testicular GCTs with distant metastases (all with prior retroperitoneal lymph node metastases) showed that metastases to the mediastinum occurred in 7% of cases.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…PMTERs often arise in the anterior mediastinum, often inside the thymus, seldom inside the pericardium 95,96 and only rarely in the posterior mediastinum. [42][43][44]97 Remnant thymic tissue adjacent to PMTERs is therefore a common finding.…”

Section: P R I M a R Y M E D I A S T I N A L T E R A T O M Amentioning

confidence: 99%

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Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Fichtner,

Marx,

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et al. 2023

Histopathology

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This article will review current aspects of the histopathological, immunohistochemical and molecular analysis of primary mediastinal germ cell tumours (PMGCTs) as well as their aetiological, epidemiological, clinical and therapeutic features. PMGCTs represent an important differential diagnosis in the spectrum of mediastinal tumours, and their diagnosis is usually made on small tissue samples from core needle biopsies in combination with diagnostic imaging and serum tumour markers. As in lymphomas, a small biopsy is often the only viable tumour sample available from these patients, as they receive chemotherapy prior to eventual surgical resection. Pathologists therefore need to apply an efficient combination of immunohistochemical markers to confirm the diagnosis of a PMGCT and to exclude morphological mimics.

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Malignant transformation of posterior mediastinal teratoma to adenocarcinoma

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Case report: A unique case of benign teratoma in the posterior mediastinum associated with anterior meningomyelocele in a one-year-old child

Cited by 3 publications

References 16 publications

Treatment of an anterior cervicothoracic myelomeningocele together with spine deformity correction in a child: illustrative case

Treatment of an anterior cervicothoracic myelomeningocele together with spine deformity correction in a child: illustrative case

Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Malignant transformation of posterior mediastinal teratoma to adenocarcinoma

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