Case Report: A 70-Year-Old Man with Undiagnosed Factor VII Deficiency Presented with Acute Ischemic Stroke

Ip, H. M. H.; Chan, Anna; Ng, Kit-Chung; Soo, Yannie; Wong, Ka Sing

doi:10.1016/j.jstrokecerebrovasdis.2013.05.035

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…2,6,16 The A/V thrombosis ratio was 5.37 (Table 1). In the case of FVII deficiency, five patients had arterial thrombosis including one case of DIC, again considered as peripheral artery disease 2,18 whereas 30 patients had venous thrombosis. 2,19,20 Twenty-six of these had deep vein thrombosis (DVT) with or without pulmonary embolism (PE); there were two cases of superficial venous thrombosis, one case of cerebral sinuses thrombosis and one case of splanchnic vein thrombosis.…”

Section: Resultsmentioning

confidence: 99%

Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation

et al. 2016

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“…FVIIa is significantly higher in the patients with type 2 diabetes mellitus 39 . FVII deficiency is an uncommon coagulation disorder that patient usually presents with bleeding diathesis, but thrombotic event was reported in patients with acute ishemic stroke 40 . Increasing of the FVII levels in our study may indicate possible reduction of a risk for venous or arterial thrombosis after 8-week training.…”

Section: Discussionmentioning

confidence: 99%

Correlation between coagulation and inflammation state in patients with diabetes mellitus type 2 in relation to gender differences: Is there any impact of eight-week exercise training?

Trebinjac

Petronić²,

Lalić

et al. 2019

VOJNOSANIT PREGL

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Background/Aim. The hypercoagulable state and inflammation state in diabetics has been widely studied by previous researchers, but there is a lack of research about a possible impact of exercise training on this relationship. The aim of this study was to assess and compare correlation between the coagulation and inflammation status in patients with type 2 diabetes mellitus taking into account the gender differences as well as an impact of the 8-week exercise training on the correlation coefficient and parameters of the inflammation and coagulation state. Methods. A total of 60 patients in stable clinical condition and well-regulated diabetic status passed through all phases of the study. The exercise training included the exercise program as interval training with estimated intensity uphill to 75% of a maximal heart rate in particular individual, 5 times a week for 8 weeks, and walking for 30 minutes with a speed of 5 km/h, 5 times a week for 8 weeks. Further fibrinolytic, coagulation and inflammatory parameters were analyzed before and after the study: D-dimer, von Willebrand factor (vWF), fibrinogen, high sensitivity CRP (hs-CRP), leukocytes, thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT) and coagulation factors: FII, FV, FVII and FX. Results. Our research showed a statistically significant reduction in the mean vWF levels after intervention both at the males (p < 0.001) and females (p < 0.001). According to a correlation analysis between hs-CRP and fibrinogen, there was a positive correlation as baseline both at the males (p < 0.05, r = 0.492) and females (p < 0.01, r = 0.516) which became weaker in the males (p < 0.01, r = 0.449) and disappeared in the females (p < 0.05, r = 0.059) after intervention. The correlation which existed as baseline in the males between D-dimer and either hs-CRP (p < 0.01, r = 0.633) or fibrinogen (p < 0.01, r = 0.673) as well as the correlation between hs-CRP and FII (p < 0.01, r = 0.728), FV (p < 0.05, r = 0.366), FVII (p < 0.05, r = 0.373) coagulation as well as between D-dimer and FII (p < 0.01, r = 0.851), FVII (p < 0.05, r = 0.367)was absent in the females. Our research demonstrated a weakening correlations in the males after intervention between D-dimer and hs-CRP (p < 0.05, r = 0.378), between hs-CRP and FII (p < 0.01, r = 0.501), FV (p < 0.05, r = 0.298), FVII (p < 0.05, r = 0.351) as well as between D-dimer and FII (p < 0.01, r = 0.759), and FVII (p < 0.05, r = 0.296). The increase of the FX values (p < 0.05) in the females after intervention suggested the possible antiinflammatory effect of exercise training. Conclusion. According to previous research, the higher levels of vWF was associated with a risk of cardiovascular disease in people with type 2 diabetes mellitus and vWF may be a risk factor unique to these populations. We demonstrated that the 8-week exercise training can significantly reduce the value of vWF in the males and females, suggesting a potential beneficial effect on the endothelial function parameters. Our research demonstrated a stronger correlation between the coagulation and inflammation parameters as baseline in the males than in the females with type 2 diabetes mellitus. According to our results, the 8-week exercise training lead to a weakening of the strength of correlation between the coagulation and inflammation parameters in the males and complete disappearance of this correlation in the females, suggesting a unique effect of exercise training that should be explored in future research.

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“…28 Interestingly, a case of patient with FVII deficiency who presented with acute ischemic stroke has also been reported. 29…”

Section: Discussionmentioning

confidence: 99%

“…28 Interestingly, a case of patient with FVII deficiency who presented with acute ischemic stroke has also been reported. 29 In this study, FVII, FVIIa-AT, total TF, and MPs-TF levels were assessed at the time of diagnosis and 1 week after in the 2 treatment groups. In our data, the patients with thrombolysis exhibited lower plasma FVII levels 1 week after stroke diagnosis in comparison with the first day levels.…”

Section: Discussionmentioning

confidence: 99%

Assessing Circulating Factor VIIa–Antithrombin Complexes in Acute Ischemic Stroke: A Pilot Study

Słomka

Świtońska

Sinkiewicz

et al. 2016

Clin Appl Thromb Hemost

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Case Report: A 70-Year-Old Man with Undiagnosed Factor VII Deficiency Presented with Acute Ischemic Stroke

Cited by 4 publications

References 8 publications

Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation

Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation

Correlation between coagulation and inflammation state in patients with diabetes mellitus type 2 in relation to gender differences: Is there any impact of eight-week exercise training?

Assessing Circulating Factor VIIa–Antithrombin Complexes in Acute Ischemic Stroke: A Pilot Study

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