Case report 554

Archer, Ann G.; Nelson, Martha C.; Abbondanzo, Susan L.; Bogumill, George P.

doi:10.1007/bf00361430

Cited by 9 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TAG C54:9, C58:5, C60:5, C56:6, C58:4, C58:6, C56:8 and C56:6. These TAG might include, in accordance to literature, the omega-3 PUFAs docosahexaenoic acid (C22:6) and eicosapentaenoic acid (C20:5), which are discussed to play a role in AD pathology 22 , 31 – 34 . Although total TAG were increased in liver tissue upon acitretin treatment, we also found individual TAG species to be decreased.…”

Section: Resultssupporting

confidence: 61%

Shotgun lipidomics of liver and brain tissue of Alzheimer’s disease model mice treated with acitretin

Lauer

Janitschke

Guilherme

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a very frequent neurodegenerative disorder characterized by an accumulation of amyloid-β (Aβ). Acitretin, a retinoid-derivative and approved treatment for Psoriasis vulgaris, increases non-amyloidogenic Amyloid-Precursor-Protein-(APP)-processing, prevents Aβ-production and elicits cognitive improvement in AD mouse models. As an unintended side effect, acitretin could result in hyperlipidemia. Here, we analyzed the impact of acitretin on the lipidome in brain and liver tissue in the 5xFAD mouse-model. In line with literature, triglycerides were increased in liver accompanied by increased PCaa, plasmalogens and acyl-carnitines, whereas SM-species were decreased. In brain, these effects were partially enhanced or similar but also inverted. While for SM and plasmalogens similar effects were found, PCaa, TAG and acyl-carnitines showed an inverse effect in both tissues. Our findings emphasize, that potential pharmaceuticals to treat AD should be carefully monitored with respect to lipid-homeostasis because APP-processing itself modulates lipid-metabolism and medication might result in further and unexpected changes. Moreover, deducing effects of brain lipid-homeostasis from results obtained for other tissues should be considered cautiously. With respect to acitretin, the increase in brain plasmalogens might display a further positive probability in AD-treatment, while other results, such as decreased SM, indicate the need of medical surveillance for treated patients.

show abstract

Section: Resultssupporting

confidence: 61%

Shotgun lipidomics of liver and brain tissue of Alzheimer’s disease model mice treated with acitretin

Lauer

Janitschke

Guilherme

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…However, MFH arising within or associated with skeletal infarction is exceptional, since only 32 cases (reviewed in [4,7]) have been tabulated in the literature. These BIs were related to decompression sickness [15], vasculitis [13], alcohol abuse [7], sickle cell anemia [8,15], or steroid therapy [2,17]. These BIs were related to decompression sickness [15], vasculitis [13], alcohol abuse [7], sickle cell anemia [8,15], or steroid therapy [2,17].…”

Section: Discussionmentioning

confidence: 99%

“…Typically, a low signal area is present on T1-and T2-weighted images. A thin band of low signal delimits the margins of the BI [2,16]. These MR features are similar for medullary bone infarction [18].…”

Section: Discussionmentioning

confidence: 99%

Case report 656

et al. 1991

View full text Add to dashboard Cite

A case is presented of a 55-year-old man with a MFH in a previous BI. The poor prognosis of such secondary MFH is related in part to the difficulty of its early diagnosis, its aggressive behavior, and its tendency to metastasize (mainly to bone sites and lungs). Nevertheless, although biopsy of asymptomatic bone marrow infarction is not indicated, MRI seems consistent in detecting sarcomatous transformation of symptomatic BIs and plays an important role in the patient's preoperative evaluation.

show abstract

Perfusionsstörungen des Knochens und Knochenmarks

Skeletterkrankungen

View full text Add to dashboard Cite

Case report 554

Cited by 9 publications

References 26 publications

Shotgun lipidomics of liver and brain tissue of Alzheimer’s disease model mice treated with acitretin

Shotgun lipidomics of liver and brain tissue of Alzheimer’s disease model mice treated with acitretin

Case report 656

Perfusionsstörungen des Knochens und Knochenmarks

Contact Info

Product

Resources

About