Case of primary bilateral diffuse large B-cell lymphoma of the ovary with plasmablastic features in an HIV-negative female patient

Abstract

A 37-year-old woman from Puerto Rico presented to our clinic with symptoms of an abdominal distension progressively worsening over 1 year. A CT of an abdomen and pelvis with contrast was performed and revealed bilateral large heterogeneous pelvic adnexal masses with large ascites and right pleural effusion. Tumour markers CA 125 was 766 U/mL and lactate dehydrogenase was 654 U/L. She underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy with pelvic lymph node dissection and partial omentectomy. Pathology of ovarian masses revealed a diffuse large B-cell lymphoma. The staging work-up was negative, which pointed towards the diagnosis of primary ovarian lymphoma. The patient completed 8 cycles of cyclophosphamide, doxorubicin, vincristine, prednisolone chemotherapy. After 18 months of chemotherapy completion, she remains in remission.

Primary Large B-cell Lymphoma of the Ovary Mimicking Meigs Syndrome: A Case Report

“…Once it is disseminated, it is difficult to determine the lymphoma is primary or secondary. Although the ovary is often a site of secondary lymphomatous spread [1][2][3][4], our patient had no evidence of extraovarian involvement on staging investigations: negative cytological findings of pleural effusion, the operative findings of the solitary large mass originating ovary without any peritoneal implants, and postoperative decrease of soluble IL2R level. The pathogenesis of the production of ascitic and pleural effusion in Meigs syndrome in uncertain.…”

“…Primary ovarian lymphoma has been described as a very rare occurrence accounting for 0.5-1% of all non-Hodgkin's lymphoma, but secondary involvement of the ovaries by lymphoma may occur more frequently at late stage (20-30%) [1][2][3][4]. Primary extranodal lymphoma is less aggressive as 5 years survival rate is 80 % whereas it is 30% in secondary lymphoma [5].…”

A rare case of plasmablastic lymphoma of the ovary with synchronous lung malignancy

“…Plasmablastic subtype in primary ovarian lymphoma is extremely rare with two reported cases so far. [ 6 7 ]…”

Pitfalls of Frozen Section in Gynecological Pathology: A Rare Case of Ovarian Lymphoma in an HIV-Positive Woman Resembling Dysgerminoma on Frozen Section

“…Primary lymphoma of the ovary is an exceptionally rare tumor, and systemic lymphoma initially presenting as an ovarian mass is uncommon as well, although systemic lymphoma involving the ovary is not rare. 1,2 Lymphoma of the ovary in an HIV-positive woman is exceptionally rare, with only a few case reports in the literature. 3,4 Because of the rarity, this diagnosis may not be considered during intraoperative consultation.…”